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Geographic and ethnic variation in Parkinson disease: a population-based study of US Medicare beneficiaries.
Neuroepidemiology. 2010; 34(3):143-51.N

Abstract

BACKGROUND

Parkinson disease is a common neurodegenerative disease. The racial, sex, age, and geographic distributions of Parkinson disease in the US are unknown.

METHODS

We performed a serial cross-sectional study of US Medicare beneficiaries aged 65 and older from the years 1995, and 2000-2005. Using over 450,000 Parkinson disease cases per year, we calculated Parkinson disease prevalence and annual incidence by race, age, sex, and county. Spatial analysis investigated the geographic distribution of Parkinson disease.

RESULTS

Age-standardized Parkinson disease prevalence (per 100,000) was 2,168.18 (+/-95.64) in White men, but 1,036.41 (+/-86.01) in Blacks, and 1,138.56 (+/-46.47) in Asians. The incidence ratio in Blacks as compared to Whites (0.74; 95% CI = 0.732-0.748) was higher than the prevalence ratio (0.58; 95% CI = 0.575-0.581), whereas the incidence ratio for Asians (0.69; 95% CI = 0.657-0.723) was similar to the prevalence ratio (0.62; 95% CI = 0.617-0.631). Bayesian mapping of Parkinson disease revealed a concentration in the Midwest and Northeast regions. Mean county incidence by quartile ranged from 279 to 3,111, and prevalence from 1,175 to 13,800 (per 100,000). Prevalence and incidence in urban counties were greater than in rural ones (p < 0.01). Cluster analysis supported a nonrandom distribution of both incident and prevalent Parkinson disease cases (p < 0.001).

CONCLUSIONS

Parkinson disease is substantially more common in Whites, and is nonrandomly distributed in the Midwest and Northeastern US.

Authors+Show Affiliations

Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO 63110, USA. wrighta@neuro.wustl.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20090375

Citation

Wright Willis, Allison, et al. "Geographic and Ethnic Variation in Parkinson Disease: a Population-based Study of US Medicare Beneficiaries." Neuroepidemiology, vol. 34, no. 3, 2010, pp. 143-51.
Wright Willis A, Evanoff BA, Lian M, et al. Geographic and ethnic variation in Parkinson disease: a population-based study of US Medicare beneficiaries. Neuroepidemiology. 2010;34(3):143-51.
Wright Willis, A., Evanoff, B. A., Lian, M., Criswell, S. R., & Racette, B. A. (2010). Geographic and ethnic variation in Parkinson disease: a population-based study of US Medicare beneficiaries. Neuroepidemiology, 34(3), 143-51. https://doi.org/10.1159/000275491
Wright Willis A, et al. Geographic and Ethnic Variation in Parkinson Disease: a Population-based Study of US Medicare Beneficiaries. Neuroepidemiology. 2010;34(3):143-51. PubMed PMID: 20090375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Geographic and ethnic variation in Parkinson disease: a population-based study of US Medicare beneficiaries. AU - Wright Willis,Allison, AU - Evanoff,Bradley A, AU - Lian,Min, AU - Criswell,Susan R, AU - Racette,Brad A, Y1 - 2010/01/15/ PY - 2009/07/26/received PY - 2009/10/14/accepted PY - 2010/1/22/entrez PY - 2010/1/22/pubmed PY - 2010/12/14/medline SP - 143 EP - 51 JF - Neuroepidemiology JO - Neuroepidemiology VL - 34 IS - 3 N2 - BACKGROUND: Parkinson disease is a common neurodegenerative disease. The racial, sex, age, and geographic distributions of Parkinson disease in the US are unknown. METHODS: We performed a serial cross-sectional study of US Medicare beneficiaries aged 65 and older from the years 1995, and 2000-2005. Using over 450,000 Parkinson disease cases per year, we calculated Parkinson disease prevalence and annual incidence by race, age, sex, and county. Spatial analysis investigated the geographic distribution of Parkinson disease. RESULTS: Age-standardized Parkinson disease prevalence (per 100,000) was 2,168.18 (+/-95.64) in White men, but 1,036.41 (+/-86.01) in Blacks, and 1,138.56 (+/-46.47) in Asians. The incidence ratio in Blacks as compared to Whites (0.74; 95% CI = 0.732-0.748) was higher than the prevalence ratio (0.58; 95% CI = 0.575-0.581), whereas the incidence ratio for Asians (0.69; 95% CI = 0.657-0.723) was similar to the prevalence ratio (0.62; 95% CI = 0.617-0.631). Bayesian mapping of Parkinson disease revealed a concentration in the Midwest and Northeast regions. Mean county incidence by quartile ranged from 279 to 3,111, and prevalence from 1,175 to 13,800 (per 100,000). Prevalence and incidence in urban counties were greater than in rural ones (p < 0.01). Cluster analysis supported a nonrandom distribution of both incident and prevalent Parkinson disease cases (p < 0.001). CONCLUSIONS: Parkinson disease is substantially more common in Whites, and is nonrandomly distributed in the Midwest and Northeastern US. SN - 1423-0208 UR - https://www.unboundmedicine.com/medline/citation/20090375/Geographic_and_ethnic_variation_in_Parkinson_disease:_a_population_based_study_of_US_Medicare_beneficiaries_ L2 - https://www.karger.com?DOI=10.1159/000275491 DB - PRIME DP - Unbound Medicine ER -