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Testosterone, SHBG and cardiovascular health in postmenopausal women.
Int J Impot Res. 2010 Mar-Apr; 22(2):91-104.IJ

Abstract

Cardiovascular disease (CVD) affects men and women differently with women having a lower incidence and later onset of disease. Research has recently refocused interest on the cardiovascular role of androgens. The purpose of this review is to summarize the evidence available on the association between testosterone and cardiovascular health in postmenopausal women. Published studies relating testosterone and sex hormone-binding globulin (SHBG) to CVD and its risk factors were reviewed. Studies included in this review suggest that increased androgenicity, characterized by high testosterone and low SHBG levels, is associated with an adverse CVD risk factor profile in postmenopausal women. However, evidence for an association with cardiovascular events is lacking and it is uncertain whether the observed associations with endogenous testosterone have clinical implications regarding the use of postmenopausal testosterone therapy. Large-scale, longitudinal studies relating testosterone and SHBG levels to cardiovascular risk factors and endpoints are needed to determine the temporal relationship between androgenicity and cardiovascular risk and to ascertain the long-term efficacy and safety of testosterone therapy in postmenopausal women.

Authors+Show Affiliations

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20090761

Citation

Brand, J S., and Y T. van der Schouw. "Testosterone, SHBG and Cardiovascular Health in Postmenopausal Women." International Journal of Impotence Research, vol. 22, no. 2, 2010, pp. 91-104.
Brand JS, van der Schouw YT. Testosterone, SHBG and cardiovascular health in postmenopausal women. Int J Impot Res. 2010;22(2):91-104.
Brand, J. S., & van der Schouw, Y. T. (2010). Testosterone, SHBG and cardiovascular health in postmenopausal women. International Journal of Impotence Research, 22(2), 91-104. https://doi.org/10.1038/ijir.2009.64
Brand JS, van der Schouw YT. Testosterone, SHBG and Cardiovascular Health in Postmenopausal Women. Int J Impot Res. 2010 Mar-Apr;22(2):91-104. PubMed PMID: 20090761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Testosterone, SHBG and cardiovascular health in postmenopausal women. AU - Brand,J S, AU - van der Schouw,Y T, Y1 - 2010/01/21/ PY - 2010/1/22/entrez PY - 2010/1/22/pubmed PY - 2010/6/9/medline SP - 91 EP - 104 JF - International journal of impotence research JO - Int J Impot Res VL - 22 IS - 2 N2 - Cardiovascular disease (CVD) affects men and women differently with women having a lower incidence and later onset of disease. Research has recently refocused interest on the cardiovascular role of androgens. The purpose of this review is to summarize the evidence available on the association between testosterone and cardiovascular health in postmenopausal women. Published studies relating testosterone and sex hormone-binding globulin (SHBG) to CVD and its risk factors were reviewed. Studies included in this review suggest that increased androgenicity, characterized by high testosterone and low SHBG levels, is associated with an adverse CVD risk factor profile in postmenopausal women. However, evidence for an association with cardiovascular events is lacking and it is uncertain whether the observed associations with endogenous testosterone have clinical implications regarding the use of postmenopausal testosterone therapy. Large-scale, longitudinal studies relating testosterone and SHBG levels to cardiovascular risk factors and endpoints are needed to determine the temporal relationship between androgenicity and cardiovascular risk and to ascertain the long-term efficacy and safety of testosterone therapy in postmenopausal women. SN - 1476-5489 UR - https://www.unboundmedicine.com/medline/citation/20090761/Testosterone_SHBG_and_cardiovascular_health_in_postmenopausal_women_ L2 - https://doi.org/10.1038/ijir.2009.64 DB - PRIME DP - Unbound Medicine ER -