Tags

Type your tag names separated by a space and hit enter

Evaluation of serum transferrin receptor and sTfR ferritin indices in diagnosing and differentiating iron deficiency anemia from anemia of chronic disease.
Indian J Pediatr. 2010 Feb; 77(2):179-83.IJ

Abstract

OBJECTIVE

The present study was conducted to assess the utility of serum transferrin receptor (sTfR) and sTfR ferritin indices to differentiate ACD from IDA and also to diagnose coexisting IDA and ACD.

METHODS

The study group comprised of 30 IDA patients, 30 cases of ACD and 30 age and sex matched controls. Complete hemogram with peripheral smear examination, markers of ACD, iron profile including serum ferritin and serum transferrin receptor levels were done in all patients and controls. Serum TfR and ferritin indices were calculated.

RESULTS

sTfR levels were significantly higher in the IDA group compared to ACD group (p<0.001). ACD group was further subdivided into two groups on the basis of sTfR levels (B1<3 microg/ml and B2 > or = microg/ml), suggesting coexisting IDA in group B2. sTfR/log ferritin index was > 1.5 in all cases of IDA and ACD with coexisting IDA while all pure ACD cases and control subjects had sTfR/log ferritin index < 1.5. All case in IDA group had log sTfR/serum ferritin index > 2.55 and all patients with ACD with or without associated iron deficiency had log sTfR/serum ferritin ratio < 2.55.

CONCLUSION

The sTfR levels along with the above mentioned indices can be very useful in differentiating pure IDA, ACD and ACD with coexisting iron deficiency, thus providing a noninvasive alternative to bone marrow iron.

Authors+Show Affiliations

Department of Pathology, Lady Hardinge Medical College and associated Kalawati Saran Children's Hospital, New Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20091370

Citation

Jain, Shilpa, et al. "Evaluation of Serum Transferrin Receptor and sTfR Ferritin Indices in Diagnosing and Differentiating Iron Deficiency Anemia From Anemia of Chronic Disease." Indian Journal of Pediatrics, vol. 77, no. 2, 2010, pp. 179-83.
Jain S, Narayan S, Chandra J, et al. Evaluation of serum transferrin receptor and sTfR ferritin indices in diagnosing and differentiating iron deficiency anemia from anemia of chronic disease. Indian J Pediatr. 2010;77(2):179-83.
Jain, S., Narayan, S., Chandra, J., Sharma, S., Jain, S., & Malhan, P. (2010). Evaluation of serum transferrin receptor and sTfR ferritin indices in diagnosing and differentiating iron deficiency anemia from anemia of chronic disease. Indian Journal of Pediatrics, 77(2), 179-83. https://doi.org/10.1007/s12098-009-0302-z
Jain S, et al. Evaluation of Serum Transferrin Receptor and sTfR Ferritin Indices in Diagnosing and Differentiating Iron Deficiency Anemia From Anemia of Chronic Disease. Indian J Pediatr. 2010;77(2):179-83. PubMed PMID: 20091370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of serum transferrin receptor and sTfR ferritin indices in diagnosing and differentiating iron deficiency anemia from anemia of chronic disease. AU - Jain,Shilpa, AU - Narayan,Shashi, AU - Chandra,Jagdish, AU - Sharma,Sunita, AU - Jain,Sonal, AU - Malhan,Priya, Y1 - 2010/01/20/ PY - 2009/04/10/received PY - 2009/08/19/accepted PY - 2010/1/22/entrez PY - 2010/1/22/pubmed PY - 2010/5/22/medline SP - 179 EP - 83 JF - Indian journal of pediatrics JO - Indian J Pediatr VL - 77 IS - 2 N2 - OBJECTIVE: The present study was conducted to assess the utility of serum transferrin receptor (sTfR) and sTfR ferritin indices to differentiate ACD from IDA and also to diagnose coexisting IDA and ACD. METHODS: The study group comprised of 30 IDA patients, 30 cases of ACD and 30 age and sex matched controls. Complete hemogram with peripheral smear examination, markers of ACD, iron profile including serum ferritin and serum transferrin receptor levels were done in all patients and controls. Serum TfR and ferritin indices were calculated. RESULTS: sTfR levels were significantly higher in the IDA group compared to ACD group (p<0.001). ACD group was further subdivided into two groups on the basis of sTfR levels (B1<3 microg/ml and B2 > or = microg/ml), suggesting coexisting IDA in group B2. sTfR/log ferritin index was > 1.5 in all cases of IDA and ACD with coexisting IDA while all pure ACD cases and control subjects had sTfR/log ferritin index < 1.5. All case in IDA group had log sTfR/serum ferritin index > 2.55 and all patients with ACD with or without associated iron deficiency had log sTfR/serum ferritin ratio < 2.55. CONCLUSION: The sTfR levels along with the above mentioned indices can be very useful in differentiating pure IDA, ACD and ACD with coexisting iron deficiency, thus providing a noninvasive alternative to bone marrow iron. SN - 0973-7693 UR - https://www.unboundmedicine.com/medline/citation/20091370/Evaluation_of_serum_transferrin_receptor_and_sTfR_ferritin_indices_in_diagnosing_and_differentiating_iron_deficiency_anemia_from_anemia_of_chronic_disease_ L2 - https://dx.doi.org/10.1007/s12098-009-0302-z DB - PRIME DP - Unbound Medicine ER -