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Serum ceruloplasmin and copper are early biomarkers for traumatic brain injury-associated elevated intracranial pressure.
J Neurosci Res. 2010 Jun; 88(8):1719-26.JN

Abstract

High intracranial pressure (ICP) is a prominent secondary pathology after traumatic brain injury (TBI) and is a major contributor to morbidity and mortality. Currently, there are no clinically proven methods for predicting which TBI patients will develop high ICP. In the present study, we examined whether the serum levels of the copper-binding protein ceruloplasmin are differentially altered in patients with elevated ICP (> or =25 mmHg) vs. those whose ICP remained below 20 mmHg throughout the study period. Consistent with its role as an acute-phase reactant, we found that ceruloplasmin levels were significantly increased by 3 days post-TBI compared with healthy volunteers. However, prior to this delayed increase, ceruloplasmin levels during the first 24 hr following injury were found to be significantly reduced in patients who subsequently developed high ICP. This decrease was found to have prognostic accuracy in delineating TBI patients based on their ICP status (cutoff of 140 microg/ml; sensitivity: 87%, specificity: 73%), Likewise, low total serum copper (below 1.32 microg/ml) was also found to be predictive of high ICP (sensitivity 86%, specificity 73%). These results suggest that initial serum ceruloplasmin/copper levels may have diagnostic value in predicting patients at risk for developing high intracranial pressure.

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Authors+Show Affiliations

Dash PK
Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, TX 77225, USA. p.dash@uth.tmc.edu
Redell JB
No affiliation info available
Hergenroeder G
No affiliation info available
Zhao J
No affiliation info available
Clifton GL
No affiliation info available
Moore A
No affiliation info available

MeSH

AdolescentAdultAgedAnalysis of VarianceBiomarkersBrain InjuriesCeruloplasminCopperEnzyme-Linked Immunosorbent AssayFemaleHumansIntracranial HypertensionMaleMiddle AgedTime FactorsYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20091772

Citation

Dash, Pramod K., et al. "Serum Ceruloplasmin and Copper Are Early Biomarkers for Traumatic Brain Injury-associated Elevated Intracranial Pressure." Journal of Neuroscience Research, vol. 88, no. 8, 2010, pp. 1719-26.
Dash PK, Redell JB, Hergenroeder G, et al. Serum ceruloplasmin and copper are early biomarkers for traumatic brain injury-associated elevated intracranial pressure. J Neurosci Res. 2010;88(8):1719-26.
Dash, P. K., Redell, J. B., Hergenroeder, G., Zhao, J., Clifton, G. L., & Moore, A. (2010). Serum ceruloplasmin and copper are early biomarkers for traumatic brain injury-associated elevated intracranial pressure. Journal of Neuroscience Research, 88(8), 1719-26. https://doi.org/10.1002/jnr.22336
Dash PK, et al. Serum Ceruloplasmin and Copper Are Early Biomarkers for Traumatic Brain Injury-associated Elevated Intracranial Pressure. J Neurosci Res. 2010;88(8):1719-26. PubMed PMID: 20091772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum ceruloplasmin and copper are early biomarkers for traumatic brain injury-associated elevated intracranial pressure. AU - Dash,Pramod K, AU - Redell,John B, AU - Hergenroeder,Georgene, AU - Zhao,Jing, AU - Clifton,Guy L, AU - Moore,Anthony, PY - 2010/1/22/entrez PY - 2010/1/22/pubmed PY - 2010/7/14/medline SP - 1719 EP - 26 JF - Journal of neuroscience research JO - J Neurosci Res VL - 88 IS - 8 N2 - High intracranial pressure (ICP) is a prominent secondary pathology after traumatic brain injury (TBI) and is a major contributor to morbidity and mortality. Currently, there are no clinically proven methods for predicting which TBI patients will develop high ICP. In the present study, we examined whether the serum levels of the copper-binding protein ceruloplasmin are differentially altered in patients with elevated ICP (> or =25 mmHg) vs. those whose ICP remained below 20 mmHg throughout the study period. Consistent with its role as an acute-phase reactant, we found that ceruloplasmin levels were significantly increased by 3 days post-TBI compared with healthy volunteers. However, prior to this delayed increase, ceruloplasmin levels during the first 24 hr following injury were found to be significantly reduced in patients who subsequently developed high ICP. This decrease was found to have prognostic accuracy in delineating TBI patients based on their ICP status (cutoff of 140 microg/ml; sensitivity: 87%, specificity: 73%), Likewise, low total serum copper (below 1.32 microg/ml) was also found to be predictive of high ICP (sensitivity 86%, specificity 73%). These results suggest that initial serum ceruloplasmin/copper levels may have diagnostic value in predicting patients at risk for developing high intracranial pressure. SN - 1097-4547 UR - https://www.unboundmedicine.com/medline/citation/20091772/Serum_ceruloplasmin_and_copper_are_early_biomarkers_for_traumatic_brain_injury_associated_elevated_intracranial_pressure_ L2 - https://doi.org/10.1002/jnr.22336 DB - PRIME DP - Unbound Medicine ER -