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Ameliorating effects and mechanisms of electroacupuncture on gastric dysrhythmia, delayed emptying, and impaired accommodation in diabetic rats.
Am J Physiol Gastrointest Liver Physiol. 2010 Apr; 298(4):G563-70.AJ

Abstract

The aim of this study was to investigate the effects and mechanisms of electroacupuncture (EA) on gastric accommodation, gastric dysrhythmia, and gastric emptying (GE) in streptozotocin (STZ)-induced diabetic rats. Five experiments were performed in five groups of STZ-induced diabetic rats to study the effects of EA at ST-36 (Zusanli) on gastric slow-wave dysrhythmia, delayed GE and intestinal transit, impaired gastric accommodation, and the mechanisms of EA involving the autonomic and opioidergic pathways. We found the following: 1) EA improved gastric dysrhythmia in the diabetic rats. The normal percentage of slow waves was 55.4 +/- 2.9% at baseline and significantly increased to 69.2 +/- 2.2% with EA (P = 0.01); this effect was blocked by naloxone. 2) EA resulted in a 21.4% increase in GE and 18.2% increase in small intestinal transit in the diabetic rats. 3) EA restored diabetes-induced impairment in gastric accommodation. Gastric accommodation was 0.98 +/- 0.13 ml with sham EA and significantly increased to 1.21 +/- 0.15 ml with EA (P = 0.01), and this effect was blocked by naloxone. 4) EA increased vagal activity assessed by the spectral analysis of the heart rate variability. We concluded that EA at ST-36 improves gastric dysrhythmia, delayed GE and intestinal transit, and impaired accommodation in STZ-induced diabetic rats, and the improvement seems to be mainly mediated via the vagal pathway. EA may have a promising therapeutic potential for diabetic gastroparesis.

Authors+Show Affiliations

Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20093561

Citation

Yin, Jieyun, et al. "Ameliorating Effects and Mechanisms of Electroacupuncture On Gastric Dysrhythmia, Delayed Emptying, and Impaired Accommodation in Diabetic Rats." American Journal of Physiology. Gastrointestinal and Liver Physiology, vol. 298, no. 4, 2010, pp. G563-70.
Yin J, Chen J, Chen JD. Ameliorating effects and mechanisms of electroacupuncture on gastric dysrhythmia, delayed emptying, and impaired accommodation in diabetic rats. Am J Physiol Gastrointest Liver Physiol. 2010;298(4):G563-70.
Yin, J., Chen, J., & Chen, J. D. (2010). Ameliorating effects and mechanisms of electroacupuncture on gastric dysrhythmia, delayed emptying, and impaired accommodation in diabetic rats. American Journal of Physiology. Gastrointestinal and Liver Physiology, 298(4), G563-70. https://doi.org/10.1152/ajpgi.00252.2009
Yin J, Chen J, Chen JD. Ameliorating Effects and Mechanisms of Electroacupuncture On Gastric Dysrhythmia, Delayed Emptying, and Impaired Accommodation in Diabetic Rats. Am J Physiol Gastrointest Liver Physiol. 2010;298(4):G563-70. PubMed PMID: 20093561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ameliorating effects and mechanisms of electroacupuncture on gastric dysrhythmia, delayed emptying, and impaired accommodation in diabetic rats. AU - Yin,Jieyun, AU - Chen,Jie, AU - Chen,Jiande D Z, Y1 - 2010/01/21/ PY - 2010/1/23/entrez PY - 2010/1/23/pubmed PY - 2010/4/17/medline SP - G563 EP - 70 JF - American journal of physiology. Gastrointestinal and liver physiology JO - Am J Physiol Gastrointest Liver Physiol VL - 298 IS - 4 N2 - The aim of this study was to investigate the effects and mechanisms of electroacupuncture (EA) on gastric accommodation, gastric dysrhythmia, and gastric emptying (GE) in streptozotocin (STZ)-induced diabetic rats. Five experiments were performed in five groups of STZ-induced diabetic rats to study the effects of EA at ST-36 (Zusanli) on gastric slow-wave dysrhythmia, delayed GE and intestinal transit, impaired gastric accommodation, and the mechanisms of EA involving the autonomic and opioidergic pathways. We found the following: 1) EA improved gastric dysrhythmia in the diabetic rats. The normal percentage of slow waves was 55.4 +/- 2.9% at baseline and significantly increased to 69.2 +/- 2.2% with EA (P = 0.01); this effect was blocked by naloxone. 2) EA resulted in a 21.4% increase in GE and 18.2% increase in small intestinal transit in the diabetic rats. 3) EA restored diabetes-induced impairment in gastric accommodation. Gastric accommodation was 0.98 +/- 0.13 ml with sham EA and significantly increased to 1.21 +/- 0.15 ml with EA (P = 0.01), and this effect was blocked by naloxone. 4) EA increased vagal activity assessed by the spectral analysis of the heart rate variability. We concluded that EA at ST-36 improves gastric dysrhythmia, delayed GE and intestinal transit, and impaired accommodation in STZ-induced diabetic rats, and the improvement seems to be mainly mediated via the vagal pathway. EA may have a promising therapeutic potential for diabetic gastroparesis. SN - 1522-1547 UR - https://www.unboundmedicine.com/medline/citation/20093561/Ameliorating_effects_and_mechanisms_of_electroacupuncture_on_gastric_dysrhythmia_delayed_emptying_and_impaired_accommodation_in_diabetic_rats_ L2 - https://journals.physiology.org/doi/10.1152/ajpgi.00252.2009?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -