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Macrolide-resistant Mycoplasma pneumoniae: characteristics of isolates and clinical aspects of community-acquired pneumonia.
J Infect Chemother. 2010 Apr; 16(2):78-86.JI

Abstract

Mycoplasma pneumoniae is one of the main pathogens causing community-acquired respiratory tract infections in children and adults. Macrolide (ML) antibiotics are recognized generally as first-choice agents for M. pneumoniae infections, and these antibiotics were thought to have excellent effectiveness against M. pneumoniae for many years. In 2000, however, M. pneumoniae showing resistance to macrolides was isolated from clinical samples obtained from Japanese pediatric patients with community-acquired pneumonia (CAP). Since then, prevalence of ML-resistant M. pneumoniae isolates in pediatric patients has increased rapidly. In 2007, ML-resistant M. pneumoniae isolates were obtained from Japanese adults with CAP; numbers of such isolates also have gradually increased in Japan. Recently, similar antimicrobial resistance in M. pneumoniae has begun to emerge worldwide. In this review, we focus on changes of ML-resistant M. pneumoniae from year to year and consider resistance mechanisms as well as clinical features of patients with resistant M. pneumoniae infection.

Authors+Show Affiliations

Laboratory of Molecular Epidemiology for Infectious Agents, Graduate School of Infection Control Sciences, Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minatoku, Tokyo, 108-8641, Japan. miyuki@lisci.kitasato-u.ac.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20094751

Citation

Morozumi, Miyuki, et al. "Macrolide-resistant Mycoplasma Pneumoniae: Characteristics of Isolates and Clinical Aspects of Community-acquired Pneumonia." Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy, vol. 16, no. 2, 2010, pp. 78-86.
Morozumi M, Takahashi T, Ubukata K. Macrolide-resistant Mycoplasma pneumoniae: characteristics of isolates and clinical aspects of community-acquired pneumonia. J Infect Chemother. 2010;16(2):78-86.
Morozumi, M., Takahashi, T., & Ubukata, K. (2010). Macrolide-resistant Mycoplasma pneumoniae: characteristics of isolates and clinical aspects of community-acquired pneumonia. Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy, 16(2), 78-86. https://doi.org/10.1007/s10156-009-0021-4
Morozumi M, Takahashi T, Ubukata K. Macrolide-resistant Mycoplasma Pneumoniae: Characteristics of Isolates and Clinical Aspects of Community-acquired Pneumonia. J Infect Chemother. 2010;16(2):78-86. PubMed PMID: 20094751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macrolide-resistant Mycoplasma pneumoniae: characteristics of isolates and clinical aspects of community-acquired pneumonia. AU - Morozumi,Miyuki, AU - Takahashi,Takashi, AU - Ubukata,Kimiko, Y1 - 2010/01/22/ PY - 2009/10/06/received PY - 2010/1/23/entrez PY - 2010/1/23/pubmed PY - 2010/7/8/medline SP - 78 EP - 86 JF - Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy JO - J Infect Chemother VL - 16 IS - 2 N2 - Mycoplasma pneumoniae is one of the main pathogens causing community-acquired respiratory tract infections in children and adults. Macrolide (ML) antibiotics are recognized generally as first-choice agents for M. pneumoniae infections, and these antibiotics were thought to have excellent effectiveness against M. pneumoniae for many years. In 2000, however, M. pneumoniae showing resistance to macrolides was isolated from clinical samples obtained from Japanese pediatric patients with community-acquired pneumonia (CAP). Since then, prevalence of ML-resistant M. pneumoniae isolates in pediatric patients has increased rapidly. In 2007, ML-resistant M. pneumoniae isolates were obtained from Japanese adults with CAP; numbers of such isolates also have gradually increased in Japan. Recently, similar antimicrobial resistance in M. pneumoniae has begun to emerge worldwide. In this review, we focus on changes of ML-resistant M. pneumoniae from year to year and consider resistance mechanisms as well as clinical features of patients with resistant M. pneumoniae infection. SN - 1437-7780 UR - https://www.unboundmedicine.com/medline/citation/20094751/Macrolide_resistant_Mycoplasma_pneumoniae:_characteristics_of_isolates_and_clinical_aspects_of_community_acquired_pneumonia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1341-321X(10)70610-3 DB - PRIME DP - Unbound Medicine ER -