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In vivo skin effects of a dimethylaminoethanol (DMAE) based formulation.
Pharmazie. 2009 Dec; 64(12):818-22.P

Abstract

Dimethylaminoethanol (DMAE) has been used in anti-aging formulations but few scientifically based data address its efficacy. The aim of this study was to evaluate the effects of DMAE-based formulations on hairless mice and human skin. Formulations containing with or without DMAE were applied to the dorsum of hairless mice. Histopathological and histometric evaluations were carried out after seven days. Formulations were also applied to the ventral forearm and the lateral periocular area of human volunteers. Stratum corneum water content and skin mechanical properties were analyzed using Corneometer and Cutometer, before and after a single and repeated application. Histometric evaluations showed that formulations with or without DMAE increased the viable epidermis thickness, but only the DMAE-supplemented formulation led to increased dermal thickness. DMAE also induced increase in collagen fiber thickness, which was observed in the histopathological study. After the single and the 8-week period application on human skin, formulations with and without DMAE enhanced the stratum corneum water content in the forearm skin. Mechanical properties were not significantly modified. So, we can suggest that DMAE action is related to its effects on the dermis as observed in the histopathological and histometric studies and showed hydration effects on skin.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, University of São Paulo, Brazil. ktadini@fcfrp.usp.brNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20095140

Citation

Tadini, K A., and P M B G Maia Campos. "In Vivo Skin Effects of a Dimethylaminoethanol (DMAE) Based Formulation." Die Pharmazie, vol. 64, no. 12, 2009, pp. 818-22.
Tadini KA, Campos PM. In vivo skin effects of a dimethylaminoethanol (DMAE) based formulation. Pharmazie. 2009;64(12):818-22.
Tadini, K. A., & Campos, P. M. (2009). In vivo skin effects of a dimethylaminoethanol (DMAE) based formulation. Die Pharmazie, 64(12), 818-22.
Tadini KA, Campos PM. In Vivo Skin Effects of a Dimethylaminoethanol (DMAE) Based Formulation. Pharmazie. 2009;64(12):818-22. PubMed PMID: 20095140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo skin effects of a dimethylaminoethanol (DMAE) based formulation. AU - Tadini,K A, AU - Campos,P M B G Maia, PY - 2010/1/26/entrez PY - 2010/1/26/pubmed PY - 2010/3/10/medline SP - 818 EP - 22 JF - Die Pharmazie JO - Pharmazie VL - 64 IS - 12 N2 - Dimethylaminoethanol (DMAE) has been used in anti-aging formulations but few scientifically based data address its efficacy. The aim of this study was to evaluate the effects of DMAE-based formulations on hairless mice and human skin. Formulations containing with or without DMAE were applied to the dorsum of hairless mice. Histopathological and histometric evaluations were carried out after seven days. Formulations were also applied to the ventral forearm and the lateral periocular area of human volunteers. Stratum corneum water content and skin mechanical properties were analyzed using Corneometer and Cutometer, before and after a single and repeated application. Histometric evaluations showed that formulations with or without DMAE increased the viable epidermis thickness, but only the DMAE-supplemented formulation led to increased dermal thickness. DMAE also induced increase in collagen fiber thickness, which was observed in the histopathological study. After the single and the 8-week period application on human skin, formulations with and without DMAE enhanced the stratum corneum water content in the forearm skin. Mechanical properties were not significantly modified. So, we can suggest that DMAE action is related to its effects on the dermis as observed in the histopathological and histometric studies and showed hydration effects on skin. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/20095140/In_vivo_skin_effects_of_a_dimethylaminoethanol__DMAE__based_formulation_ DB - PRIME DP - Unbound Medicine ER -