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Effects of histamine H(1) receptor antagonists on delayed spatial win-shift task in rats.
Eur J Pharmacol. 2010 Apr 10; 631(1-3):24-7.EJ

Abstract

We investigated the effects of histamine H(1) receptor antagonists in 3 different stages of spatial working memory in comparison with scopolamine. The effects of drugs were measured using an eight-arm radial maze with a delayed spatial win-shift task in rats. Drugs were injected 10 min before the training phase (timing 1), immediately after the training phase (timing 2), or 10 min before the test phase (timing 3). Intrahippocampal injection of pyrilamine and diphenhydramine resulted in significant effects on the number of correct choices and across-phase errors in all 3 timings. Scopolamine impaired the number of correct choices and across-phase errors in timing 1 and 3; however, no significant effect was observed in timing 2. These results indicate that pyrilamine and diphenhydramine impaired encoding, retention and retrieval processes of spatial working memory, whereas scopolamine did not impair the retention process.

Authors+Show Affiliations

Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka 1-1-1, Kita-ku, Okayama 700-8530, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20096284

Citation

Okada, Akiko, et al. "Effects of Histamine H(1) Receptor Antagonists On Delayed Spatial Win-shift Task in Rats." European Journal of Pharmacology, vol. 631, no. 1-3, 2010, pp. 24-7.
Okada A, Kato A, Kamei C. Effects of histamine H(1) receptor antagonists on delayed spatial win-shift task in rats. Eur J Pharmacol. 2010;631(1-3):24-7.
Okada, A., Kato, A., & Kamei, C. (2010). Effects of histamine H(1) receptor antagonists on delayed spatial win-shift task in rats. European Journal of Pharmacology, 631(1-3), 24-7. https://doi.org/10.1016/j.ejphar.2010.01.005
Okada A, Kato A, Kamei C. Effects of Histamine H(1) Receptor Antagonists On Delayed Spatial Win-shift Task in Rats. Eur J Pharmacol. 2010 Apr 10;631(1-3):24-7. PubMed PMID: 20096284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of histamine H(1) receptor antagonists on delayed spatial win-shift task in rats. AU - Okada,Akiko, AU - Kato,Akane, AU - Kamei,Chiaki, Y1 - 2010/01/21/ PY - 2009/08/31/received PY - 2009/12/07/revised PY - 2010/01/12/accepted PY - 2010/1/26/entrez PY - 2010/1/26/pubmed PY - 2010/5/18/medline SP - 24 EP - 7 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 631 IS - 1-3 N2 - We investigated the effects of histamine H(1) receptor antagonists in 3 different stages of spatial working memory in comparison with scopolamine. The effects of drugs were measured using an eight-arm radial maze with a delayed spatial win-shift task in rats. Drugs were injected 10 min before the training phase (timing 1), immediately after the training phase (timing 2), or 10 min before the test phase (timing 3). Intrahippocampal injection of pyrilamine and diphenhydramine resulted in significant effects on the number of correct choices and across-phase errors in all 3 timings. Scopolamine impaired the number of correct choices and across-phase errors in timing 1 and 3; however, no significant effect was observed in timing 2. These results indicate that pyrilamine and diphenhydramine impaired encoding, retention and retrieval processes of spatial working memory, whereas scopolamine did not impair the retention process. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/20096284/Effects_of_histamine_H_1__receptor_antagonists_on_delayed_spatial_win_shift_task_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(10)00042-7 DB - PRIME DP - Unbound Medicine ER -