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Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme.
Vaccine. 2010 Mar 19; 28(14):2642-7.V

Abstract

We evaluated the effectiveness of the heptavalent pneumococcal conjugate vaccine (PCV7) on invasive pneumococcal disease (IPD) 1 year after PCV7's introduction in the childhood immunization programme through a nationwide cohort study based on laboratory surveillance data. There was a decline in the overall incidence of IPD from 19.4 to 17.1 cases per 100,000 population (incidence rate ratios (IRR) 0.87; 95% confidence interval (CI) [0.81-0.96]), and of meningitis from 1.56 to 1.16 (IRR 0.74; 95% CI [0.57-0.97]) comparing pre-PCV7 (years 2000-2007) and PCV7 (year 2008) periods. In children <2 years, the incidence decreased from 54 to 23 cases per 100,000 (IRR 0.43; 95% CI [0.29-0.62]) and for vaccine-serotypes from 36.7 to 7.7 (IRR 0.20; 95% CI [0.09-0.38]). The incidence of IPD declined approximately 10% (IRR 0.90; 95% CI [0.84-0.97]) in patients aged >or=2 years. The case fatality was 17% in both periods. The administration of PCV7 was followed by a marked decline in the incidence of IPD in both vaccinated and non-vaccinated individuals.

Authors+Show Affiliations

National Neisseria and Streptococcus Reference Center, Department of Bacteriology, Mycology and Parasitology, Statens Serum Institut, Copenhagen, Denmark. zit@ssi.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20096392

Citation

Harboe, Zitta B., et al. "Early Effectiveness of Heptavalent Conjugate Pneumococcal Vaccination On Invasive Pneumococcal Disease After the Introduction in the Danish Childhood Immunization Programme." Vaccine, vol. 28, no. 14, 2010, pp. 2642-7.
Harboe ZB, Valentiner-Branth P, Benfield TL, et al. Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme. Vaccine. 2010;28(14):2642-7.
Harboe, Z. B., Valentiner-Branth, P., Benfield, T. L., Christensen, J. J., Andersen, P. H., Howitz, M., Krogfelt, K. A., Lambertsen, L., & Konradsen, H. B. (2010). Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme. Vaccine, 28(14), 2642-7. https://doi.org/10.1016/j.vaccine.2010.01.017
Harboe ZB, et al. Early Effectiveness of Heptavalent Conjugate Pneumococcal Vaccination On Invasive Pneumococcal Disease After the Introduction in the Danish Childhood Immunization Programme. Vaccine. 2010 Mar 19;28(14):2642-7. PubMed PMID: 20096392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme. AU - Harboe,Zitta B, AU - Valentiner-Branth,Palle, AU - Benfield,Thomas L, AU - Christensen,Jens Jørgen, AU - Andersen,Peter H, AU - Howitz,Michael, AU - Krogfelt,Karen A, AU - Lambertsen,Lotte, AU - Konradsen,Helle B, Y1 - 2010/01/20/ PY - 2009/08/26/received PY - 2009/12/18/revised PY - 2010/01/10/accepted PY - 2010/1/26/entrez PY - 2010/1/26/pubmed PY - 2010/5/21/medline SP - 2642 EP - 7 JF - Vaccine JO - Vaccine VL - 28 IS - 14 N2 - We evaluated the effectiveness of the heptavalent pneumococcal conjugate vaccine (PCV7) on invasive pneumococcal disease (IPD) 1 year after PCV7's introduction in the childhood immunization programme through a nationwide cohort study based on laboratory surveillance data. There was a decline in the overall incidence of IPD from 19.4 to 17.1 cases per 100,000 population (incidence rate ratios (IRR) 0.87; 95% confidence interval (CI) [0.81-0.96]), and of meningitis from 1.56 to 1.16 (IRR 0.74; 95% CI [0.57-0.97]) comparing pre-PCV7 (years 2000-2007) and PCV7 (year 2008) periods. In children <2 years, the incidence decreased from 54 to 23 cases per 100,000 (IRR 0.43; 95% CI [0.29-0.62]) and for vaccine-serotypes from 36.7 to 7.7 (IRR 0.20; 95% CI [0.09-0.38]). The incidence of IPD declined approximately 10% (IRR 0.90; 95% CI [0.84-0.97]) in patients aged >or=2 years. The case fatality was 17% in both periods. The administration of PCV7 was followed by a marked decline in the incidence of IPD in both vaccinated and non-vaccinated individuals. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/20096392/Early_effectiveness_of_heptavalent_conjugate_pneumococcal_vaccination_on_invasive_pneumococcal_disease_after_the_introduction_in_the_Danish_Childhood_Immunization_Programme_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(10)00048-4 DB - PRIME DP - Unbound Medicine ER -