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Influence of body composition on bone mass in postmenopausal osteoporotic women.
Arch Gerontol Geriatr. 2010 Nov-Dec; 51(3):295-8.AG

Abstract

We aimed at evaluating the relationship of lean and fat mass to bone mass in osteoporotic postmenopausal women. We invited 65 women who were being treated at the São Paulo Hospital osteoporosis outpatients' clinic to participate. Body composition and bone mineral density (BMD) measurements were performed using Dual-energy X-ray absorptiometry methodology (DXA). The mean age and weight were 69.7±6.4 years and 56.3±7.6 kg, respectively. Accordingly to the body mass index (BMI), 52.8% were of normal weight and 47.1% of the patients were overweight. Overweight women had significantly higher bone mass. Similarly, skeletal muscle index (SMI) showed a positive effect on BMD measurements and women with sarcopenia had significantly lower BMD measurements in total femur and femoral neck. In multiple regression analysis only lean mass and age, after adjustments to fat mass and BMI, were able to predict total body bone mineral content (BMC) (R(2)=28%). Also lean mass adjusted to age and BMI were able to predict femoral neck BMD (R(2)=14%). On the other hand, none of the components of the body composition (lean mass or fat mass) contributed significantly to explaining total femur BMD and neither body composition measurements were associated with spine BMD. These findings suggest that lean mass has a relevant role in BMC and BMD measurements. In addition, lower BMI and lean mass loss (sarcopenia) is associated to lower BMC and BMD of femoral neck and total femur and possible higher risk of osteoporotic fracture.

Authors+Show Affiliations

Department of Nutrition, School of Public Health, University of São Paulo, Av. Dr. Arnaldo, 715, São Paulo, SP 01246-904, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20096469

Citation

Genaro, Patrícia S., et al. "Influence of Body Composition On Bone Mass in Postmenopausal Osteoporotic Women." Archives of Gerontology and Geriatrics, vol. 51, no. 3, 2010, pp. 295-8.
Genaro PS, Pereira GA, Pinheiro MM, et al. Influence of body composition on bone mass in postmenopausal osteoporotic women. Arch Gerontol Geriatr. 2010;51(3):295-8.
Genaro, P. S., Pereira, G. A., Pinheiro, M. M., Szejnfeld, V. L., & Martini, L. A. (2010). Influence of body composition on bone mass in postmenopausal osteoporotic women. Archives of Gerontology and Geriatrics, 51(3), 295-8. https://doi.org/10.1016/j.archger.2009.12.006
Genaro PS, et al. Influence of Body Composition On Bone Mass in Postmenopausal Osteoporotic Women. Arch Gerontol Geriatr. 2010 Nov-Dec;51(3):295-8. PubMed PMID: 20096469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of body composition on bone mass in postmenopausal osteoporotic women. AU - Genaro,Patrícia S, AU - Pereira,Giselle A P, AU - Pinheiro,Marcelo M, AU - Szejnfeld,Vera L, AU - Martini,Lígia A, Y1 - 2010/01/21/ PY - 2009/06/02/received PY - 2009/12/12/revised PY - 2009/12/19/accepted PY - 2010/1/26/entrez PY - 2010/1/26/pubmed PY - 2011/3/4/medline SP - 295 EP - 8 JF - Archives of gerontology and geriatrics JO - Arch Gerontol Geriatr VL - 51 IS - 3 N2 - We aimed at evaluating the relationship of lean and fat mass to bone mass in osteoporotic postmenopausal women. We invited 65 women who were being treated at the São Paulo Hospital osteoporosis outpatients' clinic to participate. Body composition and bone mineral density (BMD) measurements were performed using Dual-energy X-ray absorptiometry methodology (DXA). The mean age and weight were 69.7±6.4 years and 56.3±7.6 kg, respectively. Accordingly to the body mass index (BMI), 52.8% were of normal weight and 47.1% of the patients were overweight. Overweight women had significantly higher bone mass. Similarly, skeletal muscle index (SMI) showed a positive effect on BMD measurements and women with sarcopenia had significantly lower BMD measurements in total femur and femoral neck. In multiple regression analysis only lean mass and age, after adjustments to fat mass and BMI, were able to predict total body bone mineral content (BMC) (R(2)=28%). Also lean mass adjusted to age and BMI were able to predict femoral neck BMD (R(2)=14%). On the other hand, none of the components of the body composition (lean mass or fat mass) contributed significantly to explaining total femur BMD and neither body composition measurements were associated with spine BMD. These findings suggest that lean mass has a relevant role in BMC and BMD measurements. In addition, lower BMI and lean mass loss (sarcopenia) is associated to lower BMC and BMD of femoral neck and total femur and possible higher risk of osteoporotic fracture. SN - 1872-6976 UR - https://www.unboundmedicine.com/medline/citation/20096469/Influence_of_body_composition_on_bone_mass_in_postmenopausal_osteoporotic_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-4943(09)00316-1 DB - PRIME DP - Unbound Medicine ER -