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Mediterranean diet and the incidence of cardiovascular disease: a Spanish cohort.
Nutr Metab Cardiovasc Dis. 2011 Apr; 21(4):237-44.NM

Abstract

BACKGROUND AND AIM

The Mediterranean diet is considered a model for healthy eating. However, prospective evidence in Mediterranean countries evaluating the relationship between this dietary pattern and non-fatal cardiovascular events is scarce. The aim of the present study was to evaluate the association between the adherence to the Mediterranean diet and the incidence of fatal and non-fatal cardiovascular events among initially healthy middle-aged adults from the Mediterranean area.

METHODS AND RESULTS

We followed-up 13,609 participants (60 percent women, mean age: 38 years) initially free of cardiovascular disease (CVD) during 4.9 years. Participants were part of a prospective cohort study of university graduates from all regions of Spain. Baseline diet was assessed using a validated 136-item food-frequency questionnaire. A 9-point score was used to appraise adherence to the Mediterranean diet. Incident clinical events were confirmed by a review of medical records. We observed 100 incident cases of CVD. In multivariate analyses, participants with the highest adherence to the Mediterranean diet (score>6) exhibited a lower cardiovascular risk (hazard ratio=0.41, 95% confidence interval [CI]: 0.18-0.95) compared to those with the lowest score (<3). For each 2-point increment in the score, the adjusted hazard ratios were 0.80 (95% CI: 0.62-1.02) for total CVD and 0.74 (0.55-0.99) for coronary heart disease.

CONCLUSIONS

There is an inverse association between adherence to the Mediterranean diet and the incidence of fatal and non-fatal CVD in initially healthy middle-aged adults.

Authors+Show Affiliations

Department of Preventive Medicine and Public Health, Medical School-Clinica Universitaria, University of Navarra, c/ Irunlarrea, 1 Ed. Investigacion, 31080 Pamplona, Navarra, Spain. mamartinez@unav.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20096543

Citation

Martínez-González, M A., et al. "Mediterranean Diet and the Incidence of Cardiovascular Disease: a Spanish Cohort." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 21, no. 4, 2011, pp. 237-44.
Martínez-González MA, García-López M, Bes-Rastrollo M, et al. Mediterranean diet and the incidence of cardiovascular disease: a Spanish cohort. Nutr Metab Cardiovasc Dis. 2011;21(4):237-44.
Martínez-González, M. A., García-López, M., Bes-Rastrollo, M., Toledo, E., Martínez-Lapiscina, E. H., Delgado-Rodriguez, M., Vazquez, Z., Benito, S., & Beunza, J. J. (2011). Mediterranean diet and the incidence of cardiovascular disease: a Spanish cohort. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 21(4), 237-44. https://doi.org/10.1016/j.numecd.2009.10.005
Martínez-González MA, et al. Mediterranean Diet and the Incidence of Cardiovascular Disease: a Spanish Cohort. Nutr Metab Cardiovasc Dis. 2011;21(4):237-44. PubMed PMID: 20096543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mediterranean diet and the incidence of cardiovascular disease: a Spanish cohort. AU - Martínez-González,M A, AU - García-López,M, AU - Bes-Rastrollo,M, AU - Toledo,E, AU - Martínez-Lapiscina,E H, AU - Delgado-Rodriguez,M, AU - Vazquez,Z, AU - Benito,S, AU - Beunza,J J, Y1 - 2010/01/21/ PY - 2009/03/31/received PY - 2009/07/13/revised PY - 2009/10/20/accepted PY - 2010/1/26/entrez PY - 2010/1/26/pubmed PY - 2011/7/20/medline SP - 237 EP - 44 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 21 IS - 4 N2 - BACKGROUND AND AIM: The Mediterranean diet is considered a model for healthy eating. However, prospective evidence in Mediterranean countries evaluating the relationship between this dietary pattern and non-fatal cardiovascular events is scarce. The aim of the present study was to evaluate the association between the adherence to the Mediterranean diet and the incidence of fatal and non-fatal cardiovascular events among initially healthy middle-aged adults from the Mediterranean area. METHODS AND RESULTS: We followed-up 13,609 participants (60 percent women, mean age: 38 years) initially free of cardiovascular disease (CVD) during 4.9 years. Participants were part of a prospective cohort study of university graduates from all regions of Spain. Baseline diet was assessed using a validated 136-item food-frequency questionnaire. A 9-point score was used to appraise adherence to the Mediterranean diet. Incident clinical events were confirmed by a review of medical records. We observed 100 incident cases of CVD. In multivariate analyses, participants with the highest adherence to the Mediterranean diet (score>6) exhibited a lower cardiovascular risk (hazard ratio=0.41, 95% confidence interval [CI]: 0.18-0.95) compared to those with the lowest score (<3). For each 2-point increment in the score, the adjusted hazard ratios were 0.80 (95% CI: 0.62-1.02) for total CVD and 0.74 (0.55-0.99) for coronary heart disease. CONCLUSIONS: There is an inverse association between adherence to the Mediterranean diet and the incidence of fatal and non-fatal CVD in initially healthy middle-aged adults. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/20096543/Mediterranean_diet_and_the_incidence_of_cardiovascular_disease:_a_Spanish_cohort_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(09)00240-3 DB - PRIME DP - Unbound Medicine ER -