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Protective effect of quercetin against intracerebral streptozotocin induced reduction in cerebral blood flow and impairment of memory in mice.
Behav Brain Res. 2010 May 01; 209(1):73-9.BB

Abstract

The aim of the present study is to investigate the effect of quercetin, a naturally occurring flavonoid, on cerebral blood flow (CBF), brain energy metabolism, memory impairment, oxidative stress and cholinergic dysfunction in brain following intracerebral (i.c.) streptozotocin (STZ) administration in mice. STZ (0.5mg/kg, i.c.) was administered twice at an interval of 48h. We found a significant reduction in CBF as measured by Laser Doppler Flowmetry (LDF). The brain energy metabolism was also altered as evidenced by significant reduction in brain ATP content. Daily treatment with quercetin (2.5, 5 and 10mg/kg, p.o.) starting from the first dose of STZ showed a dose-dependent restoration of CBF and ATP content. Further, quercetin prevented STZ induced memory impairment as assessed by Morris water maze and passive avoidance tests. Biochemical analysis revealed that STZ significantly increased malondialdehyde (MDA), nitrite and depleted glutathione (GSH) levels in the mice brain. Quercetin decreased oxidative and nitrosative stress as evidenced by a significant decrease in MDA, nitrite and increase in GSH levels. Quercetin also attenuated elevated acetylcholinesterase activity in the STZ-treated mice. Neither STZ (i.c.) nor quercetin showed any change in locomotor activity and blood glucose level. The present study demonstrates the beneficial effects of quercetin in improving CBF along with preventing memory impairment, oxidative stress, altered brain energy metabolism and cholinergic dysfunction caused by STZ in mice. Therefore, consumption of dietary stuff rich in quercetin should be encouraged to ward off dementia associated with vascular and neurodegenerative disorders.

Authors+Show Affiliations

Division of Pharmacology, Central Drug Research Institute, CSIR, Chattar Manzil, Lucknow, U.P., India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20096732

Citation

Tota, Santoshkumar, et al. "Protective Effect of Quercetin Against Intracerebral Streptozotocin Induced Reduction in Cerebral Blood Flow and Impairment of Memory in Mice." Behavioural Brain Research, vol. 209, no. 1, 2010, pp. 73-9.
Tota S, Awasthi H, Kamat PK, et al. Protective effect of quercetin against intracerebral streptozotocin induced reduction in cerebral blood flow and impairment of memory in mice. Behav Brain Res. 2010;209(1):73-9.
Tota, S., Awasthi, H., Kamat, P. K., Nath, C., & Hanif, K. (2010). Protective effect of quercetin against intracerebral streptozotocin induced reduction in cerebral blood flow and impairment of memory in mice. Behavioural Brain Research, 209(1), 73-9. https://doi.org/10.1016/j.bbr.2010.01.017
Tota S, et al. Protective Effect of Quercetin Against Intracerebral Streptozotocin Induced Reduction in Cerebral Blood Flow and Impairment of Memory in Mice. Behav Brain Res. 2010 May 1;209(1):73-9. PubMed PMID: 20096732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of quercetin against intracerebral streptozotocin induced reduction in cerebral blood flow and impairment of memory in mice. AU - Tota,Santoshkumar, AU - Awasthi,Himani, AU - Kamat,Pradeep Kumar, AU - Nath,Chandishwar, AU - Hanif,Kashif, Y1 - 2010/01/22/ PY - 2009/08/21/received PY - 2010/01/14/revised PY - 2010/01/15/accepted PY - 2010/1/26/entrez PY - 2010/1/26/pubmed PY - 2010/5/26/medline SP - 73 EP - 9 JF - Behavioural brain research JO - Behav Brain Res VL - 209 IS - 1 N2 - The aim of the present study is to investigate the effect of quercetin, a naturally occurring flavonoid, on cerebral blood flow (CBF), brain energy metabolism, memory impairment, oxidative stress and cholinergic dysfunction in brain following intracerebral (i.c.) streptozotocin (STZ) administration in mice. STZ (0.5mg/kg, i.c.) was administered twice at an interval of 48h. We found a significant reduction in CBF as measured by Laser Doppler Flowmetry (LDF). The brain energy metabolism was also altered as evidenced by significant reduction in brain ATP content. Daily treatment with quercetin (2.5, 5 and 10mg/kg, p.o.) starting from the first dose of STZ showed a dose-dependent restoration of CBF and ATP content. Further, quercetin prevented STZ induced memory impairment as assessed by Morris water maze and passive avoidance tests. Biochemical analysis revealed that STZ significantly increased malondialdehyde (MDA), nitrite and depleted glutathione (GSH) levels in the mice brain. Quercetin decreased oxidative and nitrosative stress as evidenced by a significant decrease in MDA, nitrite and increase in GSH levels. Quercetin also attenuated elevated acetylcholinesterase activity in the STZ-treated mice. Neither STZ (i.c.) nor quercetin showed any change in locomotor activity and blood glucose level. The present study demonstrates the beneficial effects of quercetin in improving CBF along with preventing memory impairment, oxidative stress, altered brain energy metabolism and cholinergic dysfunction caused by STZ in mice. Therefore, consumption of dietary stuff rich in quercetin should be encouraged to ward off dementia associated with vascular and neurodegenerative disorders. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/20096732/Protective_effect_of_quercetin_against_intracerebral_streptozotocin_induced_reduction_in_cerebral_blood_flow_and_impairment_of_memory_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(10)00034-3 DB - PRIME DP - Unbound Medicine ER -