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Laparoscopic ovarian diathermy vs clomiphene citrate plus metformin as second-line strategy for infertile anovulatory patients with polycystic ovary syndrome: a randomized controlled trial.
Am J Obstet Gynecol. 2010 Jun; 202(6):577.e1-8.AJ

Abstract

OBJECTIVE

The purpose of this study was to compare the effectiveness of laparoscopic ovarian diathermy (LOD) vs clomiphene citrate (CC) plus metformin in infertile patients with CC-resistant polycystic ovary syndrome (PCOS).

STUDY DESIGN

Fifty primary infertile patients with CC-resistant PCOS were assigned randomly to receive LOD followed by a 6-month observation (group A) or 6-cycle course of CC plus metformin (group B). Reproductive and safety outcomes were analyzed.

RESULTS

No significant difference between 2 groups in pregnancy (15/92 women [16.3%] vs 14/107 women [13.1%]; P = .521) and live-birth (13/92 women [14.1%] vs 12/107 women [11.2%]; P = .536) rates per cycle was observed. With the use of a Cox regression analysis, patients under medical treatment, compared with patients who received surgical treatment, had a relative risk of pregnancy of 1.2 (95% confidence interval, 0.61-2.44; P = .582) and a relative risk of live-birth of 1.4 (95% confidence interval, 0.63-2.96; P = .425).

CONCLUSION

LOD and CC plus metformin seem to be 2 effective approaches to treat infertility in patients with CC-resistant PCOS.

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Authors+Show Affiliations

Palomba S
Department of Obstetrics and Gynecology, University Magna Graecia of Catanzaro, Catanzaro, Italy. stefanopalomba@tin.it
Falbo A
No affiliation info available
Battista L
No affiliation info available
Russo T
No affiliation info available
Venturella R
No affiliation info available
Tolino A
No affiliation info available
Orio F
No affiliation info available
Zullo F
No affiliation info available

MeSH

Abortion, SpontaneousAnovulationBody Mass IndexClomipheneDiathermyDrug Therapy, CombinationFemaleFertility Agents, FemaleHumansHypoglycemic AgentsInfertility, FemaleLaparoscopyLive BirthMetforminOvaryOvulation InductionPatient SelectionPolycystic Ovary SyndromePregnancySurveys and QuestionnairesTreatment Outcome

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

20096821

Citation

Palomba, Stefano, et al. "Laparoscopic Ovarian Diathermy Vs Clomiphene Citrate Plus Metformin as Second-line Strategy for Infertile Anovulatory Patients With Polycystic Ovary Syndrome: a Randomized Controlled Trial." American Journal of Obstetrics and Gynecology, vol. 202, no. 6, 2010, pp. 577.e1-8.
Palomba S, Falbo A, Battista L, et al. Laparoscopic ovarian diathermy vs clomiphene citrate plus metformin as second-line strategy for infertile anovulatory patients with polycystic ovary syndrome: a randomized controlled trial. Am J Obstet Gynecol. 2010;202(6):577.e1-8.
Palomba, S., Falbo, A., Battista, L., Russo, T., Venturella, R., Tolino, A., Orio, F., & Zullo, F. (2010). Laparoscopic ovarian diathermy vs clomiphene citrate plus metformin as second-line strategy for infertile anovulatory patients with polycystic ovary syndrome: a randomized controlled trial. American Journal of Obstetrics and Gynecology, 202(6), e1-8. https://doi.org/10.1016/j.ajog.2009.11.042
Palomba S, et al. Laparoscopic Ovarian Diathermy Vs Clomiphene Citrate Plus Metformin as Second-line Strategy for Infertile Anovulatory Patients With Polycystic Ovary Syndrome: a Randomized Controlled Trial. Am J Obstet Gynecol. 2010;202(6):577.e1-8. PubMed PMID: 20096821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Laparoscopic ovarian diathermy vs clomiphene citrate plus metformin as second-line strategy for infertile anovulatory patients with polycystic ovary syndrome: a randomized controlled trial. AU - Palomba,Stefano, AU - Falbo,Angela, AU - Battista,Lucia, AU - Russo,Tiziana, AU - Venturella,Roberta, AU - Tolino,Achille, AU - Orio,Francesco, AU - Zullo,Fulvio, Y1 - 2010/01/22/ PY - 2009/07/26/received PY - 2009/09/08/revised PY - 2009/11/24/accepted PY - 2010/1/26/entrez PY - 2010/1/26/pubmed PY - 2010/6/23/medline SP - 577.e1 EP - 8 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 202 IS - 6 N2 - OBJECTIVE: The purpose of this study was to compare the effectiveness of laparoscopic ovarian diathermy (LOD) vs clomiphene citrate (CC) plus metformin in infertile patients with CC-resistant polycystic ovary syndrome (PCOS). STUDY DESIGN: Fifty primary infertile patients with CC-resistant PCOS were assigned randomly to receive LOD followed by a 6-month observation (group A) or 6-cycle course of CC plus metformin (group B). Reproductive and safety outcomes were analyzed. RESULTS: No significant difference between 2 groups in pregnancy (15/92 women [16.3%] vs 14/107 women [13.1%]; P = .521) and live-birth (13/92 women [14.1%] vs 12/107 women [11.2%]; P = .536) rates per cycle was observed. With the use of a Cox regression analysis, patients under medical treatment, compared with patients who received surgical treatment, had a relative risk of pregnancy of 1.2 (95% confidence interval, 0.61-2.44; P = .582) and a relative risk of live-birth of 1.4 (95% confidence interval, 0.63-2.96; P = .425). CONCLUSION: LOD and CC plus metformin seem to be 2 effective approaches to treat infertility in patients with CC-resistant PCOS. SN - 1097-6868 UR - https://www.unboundmedicine.com/medline/citation/20096821/Laparoscopic_ovarian_diathermy_vs_clomiphene_citrate_plus_metformin_as_second_line_strategy_for_infertile_anovulatory_patients_with_polycystic_ovary_syndrome:_a_randomized_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9378(09)02229-7 DB - PRIME DP - Unbound Medicine ER -
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