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Acoustic startle response and sensorimotor gating in a genetic mouse model for the Y1 receptor.
Neuropeptides. 2010 Jun; 44(3):233-9.N

Abstract

Recent research has highlighted a potential role for neuropeptide Y (NPY) and its Y(1) receptor in the development of schizophrenia. Genetic as well as molecular biological studies have demonstrated reduced levels of NPY in schizophrenia patients. Importantly, Y(1) receptors may mediate some of the potential effects of NPY on schizophrenia, as decreased Y(1) receptor expression has been found in the lymphocytes of schizophrenia patients. To clarify NPY's role in schizophrenia, we investigated a genetic animal model for Y(1) deficiency in regard to (i) acoustic startle response (ASR), (ii) habituation to ASR and (iii) sensorimotor gating [i.e. prepulse inhibition (PPI)] using two different PPI protocols. Mutant and wild type-like mice were screened for baseline behaviours and after pharmacological challenge with the psychotropic drugs dexamphetamine (DEX) and MK-801. Y(1) knockout mice (Y(1)(-/-)) showed a moderate reduction of the ASR and an impaired ASR habituation at baseline and after DEX treatment. The baseline PPI performance of Y(1) mutant mice was unaltered their response to DEX and MK-801 challenge was moderately different compared to control mice, which was dependent on the PPI protocol used. MK-801 challenge had a protocol-dependent differential effect in Y(1)(-/-) mice and DEX a more pronounced impact at the highest prepulse intensities. In conclusion, it appears that the Y(1) receptor influences the acoustic startle response and its habituation but does not play a major role in sensorimotor gating. Further explorations into the effects of Y(1) deficiency seem valid.

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Authors+Show Affiliations

Karl T
Neuroscience Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia. t.karl@schizophreniaresearch.org.au
Chesworth R
No affiliation info available
Duffy L
No affiliation info available
Herzog H
No affiliation info available

MeSH

AnimalsDextroamphetamineDisease Models, AnimalDizocilpine MaleateHumansMaleMiceMice, KnockoutReceptors, Neuropeptide YReflex, StartleSchizophreniaSensory Gating

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20096928

Citation

Karl, T, et al. "Acoustic Startle Response and Sensorimotor Gating in a Genetic Mouse Model for the Y1 Receptor." Neuropeptides, vol. 44, no. 3, 2010, pp. 233-9.
Karl T, Chesworth R, Duffy L, et al. Acoustic startle response and sensorimotor gating in a genetic mouse model for the Y1 receptor. Neuropeptides. 2010;44(3):233-9.
Karl, T., Chesworth, R., Duffy, L., & Herzog, H. (2010). Acoustic startle response and sensorimotor gating in a genetic mouse model for the Y1 receptor. Neuropeptides, 44(3), 233-9. https://doi.org/10.1016/j.npep.2009.12.008
Karl T, et al. Acoustic Startle Response and Sensorimotor Gating in a Genetic Mouse Model for the Y1 Receptor. Neuropeptides. 2010;44(3):233-9. PubMed PMID: 20096928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acoustic startle response and sensorimotor gating in a genetic mouse model for the Y1 receptor. AU - Karl,T, AU - Chesworth,R, AU - Duffy,L, AU - Herzog,H, Y1 - 2010/01/25/ PY - 2009/06/30/received PY - 2009/11/24/revised PY - 2009/12/11/accepted PY - 2010/1/26/entrez PY - 2010/1/26/pubmed PY - 2010/8/6/medline SP - 233 EP - 9 JF - Neuropeptides JO - Neuropeptides VL - 44 IS - 3 N2 - Recent research has highlighted a potential role for neuropeptide Y (NPY) and its Y(1) receptor in the development of schizophrenia. Genetic as well as molecular biological studies have demonstrated reduced levels of NPY in schizophrenia patients. Importantly, Y(1) receptors may mediate some of the potential effects of NPY on schizophrenia, as decreased Y(1) receptor expression has been found in the lymphocytes of schizophrenia patients. To clarify NPY's role in schizophrenia, we investigated a genetic animal model for Y(1) deficiency in regard to (i) acoustic startle response (ASR), (ii) habituation to ASR and (iii) sensorimotor gating [i.e. prepulse inhibition (PPI)] using two different PPI protocols. Mutant and wild type-like mice were screened for baseline behaviours and after pharmacological challenge with the psychotropic drugs dexamphetamine (DEX) and MK-801. Y(1) knockout mice (Y(1)(-/-)) showed a moderate reduction of the ASR and an impaired ASR habituation at baseline and after DEX treatment. The baseline PPI performance of Y(1) mutant mice was unaltered their response to DEX and MK-801 challenge was moderately different compared to control mice, which was dependent on the PPI protocol used. MK-801 challenge had a protocol-dependent differential effect in Y(1)(-/-) mice and DEX a more pronounced impact at the highest prepulse intensities. In conclusion, it appears that the Y(1) receptor influences the acoustic startle response and its habituation but does not play a major role in sensorimotor gating. Further explorations into the effects of Y(1) deficiency seem valid. SN - 1532-2785 UR - https://www.unboundmedicine.com/medline/citation/20096928/Acoustic_startle_response_and_sensorimotor_gating_in_a_genetic_mouse_model_for_the_Y1_receptor_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0143-4179(09)00147-4 DB - PRIME DP - Unbound Medicine ER -