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Physical activity, diet, adiposity and female breast cancer prognosis: a review of the epidemiologic literature.
Maturitas 2010; 66(1):5-15M

Abstract

Given the increasing numbers of long-term survivors of breast cancer, research specific to prevention of recurrence, new breast cancer events, and mortality is of considerable public health importance. The objective of this report is to present a review of the published epidemiologic research on lifestyle and breast cancer outcomes among women with a history of breast cancer. This review focused on physical activity, diet, and adiposity; and the primary outcomes were additional breast cancer events and mortality. The most consistent finding from observational studies was that adiposity was associated with a 30% increased risk of mortality. Although the observational data were not as consistent (or abundant), physical activity appeared to be associated with a 30% decreased risk of mortality. These data do not indicate that alcoholic drinks are a risk factor. Based only on the observational studies, total dietary fat appeared to be a risk factor, fiber was protective, and information on micronutrients and specific foods was sparse. However, the null results of 2 dietary intervention trials in survivors suggests that lowering fat intake or increasing consumption of fruits, vegetables, and fiber will not lead to improved prognosis in breast cancer survivors. Given that a high proportion of breast cancer patients appear to be both sedentary and obese/overweight, clinical trials are needed to investigate whether the combination of increased physical activity and reduced adiposity can improve breast cancer prognosis.

Authors+Show Affiliations

Moores UCSD Cancer Center, University of California, San Diego, La Jolla, CA 92093-0901, USA. repatterson@ucsd.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20097494

Citation

Patterson, Ruth E., et al. "Physical Activity, Diet, Adiposity and Female Breast Cancer Prognosis: a Review of the Epidemiologic Literature." Maturitas, vol. 66, no. 1, 2010, pp. 5-15.
Patterson RE, Cadmus LA, Emond JA, et al. Physical activity, diet, adiposity and female breast cancer prognosis: a review of the epidemiologic literature. Maturitas. 2010;66(1):5-15.
Patterson, R. E., Cadmus, L. A., Emond, J. A., & Pierce, J. P. (2010). Physical activity, diet, adiposity and female breast cancer prognosis: a review of the epidemiologic literature. Maturitas, 66(1), pp. 5-15. doi:10.1016/j.maturitas.2010.01.004.
Patterson RE, et al. Physical Activity, Diet, Adiposity and Female Breast Cancer Prognosis: a Review of the Epidemiologic Literature. Maturitas. 2010;66(1):5-15. PubMed PMID: 20097494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical activity, diet, adiposity and female breast cancer prognosis: a review of the epidemiologic literature. AU - Patterson,Ruth E, AU - Cadmus,Lisa A, AU - Emond,Jennifer A, AU - Pierce,John P, Y1 - 2010/01/25/ PY - 2009/12/23/received PY - 2010/01/06/revised PY - 2010/01/06/accepted PY - 2010/1/26/entrez PY - 2010/1/26/pubmed PY - 2010/9/30/medline SP - 5 EP - 15 JF - Maturitas JO - Maturitas VL - 66 IS - 1 N2 - Given the increasing numbers of long-term survivors of breast cancer, research specific to prevention of recurrence, new breast cancer events, and mortality is of considerable public health importance. The objective of this report is to present a review of the published epidemiologic research on lifestyle and breast cancer outcomes among women with a history of breast cancer. This review focused on physical activity, diet, and adiposity; and the primary outcomes were additional breast cancer events and mortality. The most consistent finding from observational studies was that adiposity was associated with a 30% increased risk of mortality. Although the observational data were not as consistent (or abundant), physical activity appeared to be associated with a 30% decreased risk of mortality. These data do not indicate that alcoholic drinks are a risk factor. Based only on the observational studies, total dietary fat appeared to be a risk factor, fiber was protective, and information on micronutrients and specific foods was sparse. However, the null results of 2 dietary intervention trials in survivors suggests that lowering fat intake or increasing consumption of fruits, vegetables, and fiber will not lead to improved prognosis in breast cancer survivors. Given that a high proportion of breast cancer patients appear to be both sedentary and obese/overweight, clinical trials are needed to investigate whether the combination of increased physical activity and reduced adiposity can improve breast cancer prognosis. SN - 1873-4111 UR - https://www.unboundmedicine.com/medline/citation/20097494/Physical_activity_diet_adiposity_and_female_breast_cancer_prognosis:_a_review_of_the_epidemiologic_literature_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(10)00005-8 DB - PRIME DP - Unbound Medicine ER -