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PET/CT imaging: The incremental value of assessing the glucose metabolic phenotype and the structure of cancers in a single examination.
Eur J Radiol 2010; 73(3):470-80EJ

Abstract

PET/CT with the glucose analogue FDG is emerging as the most important diagnostic imaging tool in oncology. More than 2000 PET/CT scanners are operational worldwide and its unique role for diagnosing, staging, restaging and therapeutic monitoring in cancer is undisputed. Studies conducted in thousands of cancer patients have clearly indicated that the combination of molecular PET with anatomical CT imaging provides incremental diagnostic value over PET or CT alone. State of the art imaging protocols combine fully diagnostic CT scans with quality whole body PET surveys. The current review briefly describes the biological alterations of cancer cells that result in their switch to a strongly glycolytic phenotype. Different whole body imaging protocols are discussed. We summarize the evidence for the incremental value of PET/CT over CT and PET alone using imaging of sarcoma as an example. Following this section we discuss the performance of FDG-PET/CT imaging for staging, restaging and monitoring of head and neck cancer, solitary lung nodules and lung cancer, breast cancer, colorectal cancer, lymphoma and unknown primary tumors. Finally, the recently emerging evidence of a substantial impact of PET/CT imaging on patient management is presented.

Authors+Show Affiliations

Department of Molecular and Medical Pharmacology, Ahmanson Biological, Imaging Center/Nuclear Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-6948, USA. jczernin@mednet.ucla.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20097498

Citation

Czernin, Johannes, et al. "PET/CT Imaging: the Incremental Value of Assessing the Glucose Metabolic Phenotype and the Structure of Cancers in a Single Examination." European Journal of Radiology, vol. 73, no. 3, 2010, pp. 470-80.
Czernin J, Benz MR, Allen-Auerbach MS. PET/CT imaging: The incremental value of assessing the glucose metabolic phenotype and the structure of cancers in a single examination. Eur J Radiol. 2010;73(3):470-80.
Czernin, J., Benz, M. R., & Allen-Auerbach, M. S. (2010). PET/CT imaging: The incremental value of assessing the glucose metabolic phenotype and the structure of cancers in a single examination. European Journal of Radiology, 73(3), pp. 470-80. doi:10.1016/j.ejrad.2009.12.023.
Czernin J, Benz MR, Allen-Auerbach MS. PET/CT Imaging: the Incremental Value of Assessing the Glucose Metabolic Phenotype and the Structure of Cancers in a Single Examination. Eur J Radiol. 2010;73(3):470-80. PubMed PMID: 20097498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PET/CT imaging: The incremental value of assessing the glucose metabolic phenotype and the structure of cancers in a single examination. AU - Czernin,Johannes, AU - Benz,Matthias R, AU - Allen-Auerbach,Martin S, Y1 - 2010/01/25/ PY - 2009/12/01/received PY - 2009/12/15/accepted PY - 2010/1/26/entrez PY - 2010/1/26/pubmed PY - 2010/7/16/medline SP - 470 EP - 80 JF - European journal of radiology JO - Eur J Radiol VL - 73 IS - 3 N2 - PET/CT with the glucose analogue FDG is emerging as the most important diagnostic imaging tool in oncology. More than 2000 PET/CT scanners are operational worldwide and its unique role for diagnosing, staging, restaging and therapeutic monitoring in cancer is undisputed. Studies conducted in thousands of cancer patients have clearly indicated that the combination of molecular PET with anatomical CT imaging provides incremental diagnostic value over PET or CT alone. State of the art imaging protocols combine fully diagnostic CT scans with quality whole body PET surveys. The current review briefly describes the biological alterations of cancer cells that result in their switch to a strongly glycolytic phenotype. Different whole body imaging protocols are discussed. We summarize the evidence for the incremental value of PET/CT over CT and PET alone using imaging of sarcoma as an example. Following this section we discuss the performance of FDG-PET/CT imaging for staging, restaging and monitoring of head and neck cancer, solitary lung nodules and lung cancer, breast cancer, colorectal cancer, lymphoma and unknown primary tumors. Finally, the recently emerging evidence of a substantial impact of PET/CT imaging on patient management is presented. SN - 1872-7727 UR - https://www.unboundmedicine.com/medline/citation/20097498/PET/CT_imaging:_The_incremental_value_of_assessing_the_glucose_metabolic_phenotype_and_the_structure_of_cancers_in_a_single_examination_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0720-048X(09)00692-5 DB - PRIME DP - Unbound Medicine ER -