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[Endemic fungal pathogens in a rural setting of Argentina: seroepidemiological study in dogs].
Rev Iberoam Micol. 2010 Mar 31; 27(1):14-9.RI

Abstract

BACKGROUND

Three fungal species causing human disease, namely Paracoccidioides brasiliensis, Histoplasma capsulatum and Coccidioides sp., are endemic in different areas of Argentina. Rates of infection in domestic dogs have been used in other Latin American countries as indicators of the presence of these pathogens in a given area. We used such an approach to investigate the epidemiological relevance of paracoccidiodomycosis, histoplasmosis and coccidioidomycosis in our country.

AIM

To investigate the presence of P. brasiliensis, H. capsulatum and Coccidioides sp. in a rural area of Argentina called Interfluvio Teuco-Bermejito, located in Chaco province.

METHODS

We applied Western Blotting to determine the presence of specific antibodies in sera from 89 domestic dogs inhabiting the area. Antibodies against the following extra-cellular fungal antigens were investigated: gP43 of P. brasiliensis, H/M of H. capsulatum and 120, 82 and 48kDa antigen bands of Coccidioides sp.

RESULTS

Specific antibodies against H. capsulatum were found in 9/89 (10%) sera: 8 reacted against both H and M antigens and 1 only reacted against antigen M. Of these 9 sera, one showed additional anti-gp43 activity and another reacted against all the fungal antigens tested.

CONCLUSIONS

This is the first study using dog infection to assess the presence of endemic fungal pathogens in Argentina. Our results suggest that H. capsulatum is the main dimorphic fungal pathogen in the Interfluvio Teuco-Bermejito area. Therefore, the diagnosis of histoplasmosis should be taken into account in patients living in this geographic region who show pulmonary or mucocutaneous symptoms compatible with the disease.

Authors+Show Affiliations

Departamento Micología, INEI, ANLIS Dr. Carlos G. Malbrán, Buenos Aires, Argentina. ccanteros@anlis.gov.arNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

spa

PubMed ID

20097588

Citation

Canteros, Cristina Elena, et al. "[Endemic Fungal Pathogens in a Rural Setting of Argentina: Seroepidemiological Study in Dogs]." Revista Iberoamericana De Micologia, vol. 27, no. 1, 2010, pp. 14-9.
Canteros CE, Madariaga MJ, Lee W, et al. [Endemic fungal pathogens in a rural setting of Argentina: seroepidemiological study in dogs]. Rev Iberoam Micol. 2010;27(1):14-9.
Canteros, C. E., Madariaga, M. J., Lee, W., Rivas, M. C., Davel, G., & Iachini, R. (2010). [Endemic fungal pathogens in a rural setting of Argentina: seroepidemiological study in dogs]. Revista Iberoamericana De Micologia, 27(1), 14-9. https://doi.org/10.1016/j.riam.2009.11.002
Canteros CE, et al. [Endemic Fungal Pathogens in a Rural Setting of Argentina: Seroepidemiological Study in Dogs]. Rev Iberoam Micol. 2010 Mar 31;27(1):14-9. PubMed PMID: 20097588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Endemic fungal pathogens in a rural setting of Argentina: seroepidemiological study in dogs]. AU - Canteros,Cristina Elena, AU - Madariaga,María Julia, AU - Lee,William, AU - Rivas,María Cristina, AU - Davel,Graciela, AU - Iachini,Ricardo, Y1 - 2010/01/25/ PY - 2009/08/16/received PY - 2009/10/25/revised PY - 2009/11/06/accepted PY - 2010/1/26/entrez PY - 2010/1/26/pubmed PY - 2010/6/23/medline SP - 14 EP - 9 JF - Revista iberoamericana de micologia JO - Rev Iberoam Micol VL - 27 IS - 1 N2 - BACKGROUND: Three fungal species causing human disease, namely Paracoccidioides brasiliensis, Histoplasma capsulatum and Coccidioides sp., are endemic in different areas of Argentina. Rates of infection in domestic dogs have been used in other Latin American countries as indicators of the presence of these pathogens in a given area. We used such an approach to investigate the epidemiological relevance of paracoccidiodomycosis, histoplasmosis and coccidioidomycosis in our country. AIM: To investigate the presence of P. brasiliensis, H. capsulatum and Coccidioides sp. in a rural area of Argentina called Interfluvio Teuco-Bermejito, located in Chaco province. METHODS: We applied Western Blotting to determine the presence of specific antibodies in sera from 89 domestic dogs inhabiting the area. Antibodies against the following extra-cellular fungal antigens were investigated: gP43 of P. brasiliensis, H/M of H. capsulatum and 120, 82 and 48kDa antigen bands of Coccidioides sp. RESULTS: Specific antibodies against H. capsulatum were found in 9/89 (10%) sera: 8 reacted against both H and M antigens and 1 only reacted against antigen M. Of these 9 sera, one showed additional anti-gp43 activity and another reacted against all the fungal antigens tested. CONCLUSIONS: This is the first study using dog infection to assess the presence of endemic fungal pathogens in Argentina. Our results suggest that H. capsulatum is the main dimorphic fungal pathogen in the Interfluvio Teuco-Bermejito area. Therefore, the diagnosis of histoplasmosis should be taken into account in patients living in this geographic region who show pulmonary or mucocutaneous symptoms compatible with the disease. SN - 1130-1406 UR - https://www.unboundmedicine.com/medline/citation/20097588/[Endemic_fungal_pathogens_in_a_rural_setting_of_Argentina:_seroepidemiological_study_in_dogs]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1130-1406(09)00047-3 DB - PRIME DP - Unbound Medicine ER -