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Histopathological changes seen in mycosis fungoides patients after phototherapy.
Am J Dermatopathol 2010; 32(3):276-80AJ

Abstract

Early stage (IA, IB, IIA) mycosis fungoides (MF) has long been treated with various agents including oral psoralen plus UVA (PUVA), broadband and narrowband. The histopathological changes seen after phototherapy have not been clearly described. Twenty-three skin biopsy specimens of MF patients treated with phototherapy both UVA and UVB were evaluated before and 3 months after phototherapy. The clinical and histomorphological response were evaluated. Various types of epidermotropism: such as single cells, haloed cells, linearly arranged single cells, pagetoid spread, and Pautrier microabscesses were noted. Stratum corneum was classified as normal, hyperkeratotic, and parakeratotic. The epidermal thickness was noted as normal, atrophic, and hypertrophic. Spongiotic microvesiculation, presence of dilated dermal vessels, was investigated. Papillary dermis fibrosis, the presence of plasma cells, eosinophils, and extravasated erythrocytes were also examined. Epidermal hyperplasia, dermal fibrosis, loss of parakeratotic pattern, and inflammatory infiltrate were frequently observed after therapy. After phototherapy, the atypical cells rarely formed "Pautrier microabscess" or made a "linear pattern" at the base of epidermis. The cells other than lymphocytes (plasma cells, eosinophils, and erythrocytes) should also be considered regarding the phototherapy effect. A pathology report of a MF patient who has undergone successful phototherapy would describe changes resulting from phototherapy-such as fibrosis or "lack of dermal inflammation" and the absence of active epidermal cellular changes such as "Pautrier microabscess" or "linearly arranged cells."

Authors+Show Affiliations

Department of Pathology, Mersin University, School of Medicine, Mersin 33079, Turkey. dusmezduygu@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20098299

Citation

Apa, Duygu Dusmez, et al. "Histopathological Changes Seen in Mycosis Fungoides Patients After Phototherapy." The American Journal of Dermatopathology, vol. 32, no. 3, 2010, pp. 276-80.
Apa DD, Pfeiffer ES, Baz K, et al. Histopathological changes seen in mycosis fungoides patients after phototherapy. Am J Dermatopathol. 2010;32(3):276-80.
Apa, D. D., Pfeiffer, E. S., Baz, K., Kanik, E. A., & Inandioğlu, P. (2010). Histopathological changes seen in mycosis fungoides patients after phototherapy. The American Journal of Dermatopathology, 32(3), pp. 276-80. doi:10.1097/DAD.0b013e3181c89e8c.
Apa DD, et al. Histopathological Changes Seen in Mycosis Fungoides Patients After Phototherapy. Am J Dermatopathol. 2010;32(3):276-80. PubMed PMID: 20098299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histopathological changes seen in mycosis fungoides patients after phototherapy. AU - Apa,Duygu Dusmez, AU - Pfeiffer,Ebru Serinsoz, AU - Baz,Kiymet, AU - Kanik,Emine Arzu, AU - Inandioğlu,Pinar, PY - 2010/1/26/entrez PY - 2010/1/26/pubmed PY - 2010/7/28/medline SP - 276 EP - 80 JF - The American Journal of dermatopathology JO - Am J Dermatopathol VL - 32 IS - 3 N2 - Early stage (IA, IB, IIA) mycosis fungoides (MF) has long been treated with various agents including oral psoralen plus UVA (PUVA), broadband and narrowband. The histopathological changes seen after phototherapy have not been clearly described. Twenty-three skin biopsy specimens of MF patients treated with phototherapy both UVA and UVB were evaluated before and 3 months after phototherapy. The clinical and histomorphological response were evaluated. Various types of epidermotropism: such as single cells, haloed cells, linearly arranged single cells, pagetoid spread, and Pautrier microabscesses were noted. Stratum corneum was classified as normal, hyperkeratotic, and parakeratotic. The epidermal thickness was noted as normal, atrophic, and hypertrophic. Spongiotic microvesiculation, presence of dilated dermal vessels, was investigated. Papillary dermis fibrosis, the presence of plasma cells, eosinophils, and extravasated erythrocytes were also examined. Epidermal hyperplasia, dermal fibrosis, loss of parakeratotic pattern, and inflammatory infiltrate were frequently observed after therapy. After phototherapy, the atypical cells rarely formed "Pautrier microabscess" or made a "linear pattern" at the base of epidermis. The cells other than lymphocytes (plasma cells, eosinophils, and erythrocytes) should also be considered regarding the phototherapy effect. A pathology report of a MF patient who has undergone successful phototherapy would describe changes resulting from phototherapy-such as fibrosis or "lack of dermal inflammation" and the absence of active epidermal cellular changes such as "Pautrier microabscess" or "linearly arranged cells." SN - 1533-0311 UR - https://www.unboundmedicine.com/medline/citation/20098299/Histopathological_changes_seen_in_mycosis_fungoides_patients_after_phototherapy L2 - http://dx.doi.org/10.1097/DAD.0b013e3181c89e8c DB - PRIME DP - Unbound Medicine ER -