Tags

Type your tag names separated by a space and hit enter

Early life factors associated with incidence of physician-diagnosed asthma in preschool children: results from the Canadian Early Childhood Development cohort study.
J Asthma. 2010 Feb; 47(1):7-13.JA

Abstract

Background.

Asthma is a common childhood illness. The objective of this study is to determine the incidence of physician-diagnosed asthma in preschool years and its relationship to host, prenatal and postnatal factors, early childhood factors, parental factors, household factors and demographic factors. Methods. The study sample was comprised of 8,499 infants and toddlers (<2 years at baseline) enrolled in the Canadian Early Childhood Development Study. Incidence of asthma was determined when the children were in preschool age (2 to 5 years).

Results.

The 4-year cumulative incidence at preschool age was 13.7% for physician-diagnosed asthma. History of early childhood wheezing before 2 years of age was a significant risk factor for incidence of asthma in preschool years (hazard ratio (HR): 2.32; 95% confidence interval (CI): 2.04-2.65). Factors that were protective for the development of asthma were breastfeeding more than 3 months (HR: 0.82; 95% CI: 0.69-0.97); history of nose or throat infection often in childhood (HR: 0.79; 95% CI: 0.67-0.93); early daycare attendance (HR: 0.85; 95% CI: 0.74-0.98); presence of two or more siblings at birth, (HR: 0.79; 95% CI: 0.64-0.97); and dwelling in rural non- central metropolitan areas (HR: 0.81; 95% CI: 0.69-0.95). Male sex, low birth weight, childhood allergy, single parent, maternal smoking during pregnancy, maternal medication use, parental atopy, and low SES at baseline were significant risk factors for the incidence of physician-diagnosed asthma in preschool years.

Conclusion.

This study emphasizes the role of wheezing in infant and toddler age on early onset of asthma during preschool years. The results also provide additional importance of early exposures to environmental factors such as early infections, daycare attendance, and rural environment in the development of proper immune dynamics to prevent asthma.

Authors+Show Affiliations

Epidemiology Coordinating and Research (EPICORE) Centre, University of Alberta, Edmonton, Alberta, Canada T6G7T4.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20100014

Citation

Midodzi, William K., et al. "Early Life Factors Associated With Incidence of Physician-diagnosed Asthma in Preschool Children: Results From the Canadian Early Childhood Development Cohort Study." The Journal of Asthma : Official Journal of the Association for the Care of Asthma, vol. 47, no. 1, 2010, pp. 7-13.
Midodzi WK, Rowe BH, Majaesic CM, et al. Early life factors associated with incidence of physician-diagnosed asthma in preschool children: results from the Canadian Early Childhood Development cohort study. J Asthma. 2010;47(1):7-13.
Midodzi, W. K., Rowe, B. H., Majaesic, C. M., Saunders, L. D., & Senthilselvan, A. (2010). Early life factors associated with incidence of physician-diagnosed asthma in preschool children: results from the Canadian Early Childhood Development cohort study. The Journal of Asthma : Official Journal of the Association for the Care of Asthma, 47(1), 7-13. https://doi.org/10.3109/02770900903380996
Midodzi WK, et al. Early Life Factors Associated With Incidence of Physician-diagnosed Asthma in Preschool Children: Results From the Canadian Early Childhood Development Cohort Study. J Asthma. 2010;47(1):7-13. PubMed PMID: 20100014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early life factors associated with incidence of physician-diagnosed asthma in preschool children: results from the Canadian Early Childhood Development cohort study. AU - Midodzi,William K, AU - Rowe,Brian H, AU - Majaesic,Carina M, AU - Saunders,Leslie Duncan, AU - Senthilselvan,Ambikaipakan, PY - 2010/1/27/entrez PY - 2010/1/27/pubmed PY - 2010/2/23/medline SP - 7 EP - 13 JF - The Journal of asthma : official journal of the Association for the Care of Asthma JO - J Asthma VL - 47 IS - 1 N2 - Background. Asthma is a common childhood illness. The objective of this study is to determine the incidence of physician-diagnosed asthma in preschool years and its relationship to host, prenatal and postnatal factors, early childhood factors, parental factors, household factors and demographic factors. Methods. The study sample was comprised of 8,499 infants and toddlers (<2 years at baseline) enrolled in the Canadian Early Childhood Development Study. Incidence of asthma was determined when the children were in preschool age (2 to 5 years). Results. The 4-year cumulative incidence at preschool age was 13.7% for physician-diagnosed asthma. History of early childhood wheezing before 2 years of age was a significant risk factor for incidence of asthma in preschool years (hazard ratio (HR): 2.32; 95% confidence interval (CI): 2.04-2.65). Factors that were protective for the development of asthma were breastfeeding more than 3 months (HR: 0.82; 95% CI: 0.69-0.97); history of nose or throat infection often in childhood (HR: 0.79; 95% CI: 0.67-0.93); early daycare attendance (HR: 0.85; 95% CI: 0.74-0.98); presence of two or more siblings at birth, (HR: 0.79; 95% CI: 0.64-0.97); and dwelling in rural non- central metropolitan areas (HR: 0.81; 95% CI: 0.69-0.95). Male sex, low birth weight, childhood allergy, single parent, maternal smoking during pregnancy, maternal medication use, parental atopy, and low SES at baseline were significant risk factors for the incidence of physician-diagnosed asthma in preschool years. Conclusion. This study emphasizes the role of wheezing in infant and toddler age on early onset of asthma during preschool years. The results also provide additional importance of early exposures to environmental factors such as early infections, daycare attendance, and rural environment in the development of proper immune dynamics to prevent asthma. SN - 1532-4303 UR - https://www.unboundmedicine.com/medline/citation/20100014/Early_life_factors_associated_with_incidence_of_physician_diagnosed_asthma_in_preschool_children:_results_from_the_Canadian_Early_Childhood_Development_cohort_study_ L2 - https://www.tandfonline.com/doi/full/10.3109/02770900903380996 DB - PRIME DP - Unbound Medicine ER -