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Design, characterization and in vitro evaluation of stavudine-loaded microspheres.
Pharm Dev Technol. 2011 Apr; 16(2):146-51.PD

Abstract

The aim of the present study was to prepare and evaluate microspheres of Eudragit containing an antiviral drug stavudine. Microspheres were prepared by O/O solvent evaporation method using acetone/liquid paraffin system. The prepared microspheres were characterized for their micromeretic properties and entrapment efficiency; as well by Fourier transformed infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD) and scanning electron microscopy (SEM) which revealed the crystalline nature of drug in a final state. The in vitro studies revealed the controlled release of drug from microspheres up to 12 h and the best fit release kinetics was achieved with a Higuchi plot and found to be diffusion controlled. The yields of preparation and entrapment efficiencies were very high with a larger particle size for all the formulations. Mean particle size, entrapment efficiency and production yield were highly influenced by the type of polymer and polymer concentration.

Authors+Show Affiliations

Department of Pharmaceutics, Smt. R. B. Patel Mahila Pharmacy College, Atkot, Gujarat, India. subhashvaghani@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20100058

Citation

Vaghani, Subhash S., et al. "Design, Characterization and in Vitro Evaluation of Stavudine-loaded Microspheres." Pharmaceutical Development and Technology, vol. 16, no. 2, 2011, pp. 146-51.
Vaghani SS, Sureja S, Singh S, et al. Design, characterization and in vitro evaluation of stavudine-loaded microspheres. Pharm Dev Technol. 2011;16(2):146-51.
Vaghani, S. S., Sureja, S., Singh, S., Gurjar, M., Jivani, N. P., & Patel, M. M. (2011). Design, characterization and in vitro evaluation of stavudine-loaded microspheres. Pharmaceutical Development and Technology, 16(2), 146-51. https://doi.org/10.3109/10837450903544559
Vaghani SS, et al. Design, Characterization and in Vitro Evaluation of Stavudine-loaded Microspheres. Pharm Dev Technol. 2011;16(2):146-51. PubMed PMID: 20100058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Design, characterization and in vitro evaluation of stavudine-loaded microspheres. AU - Vaghani,Subhash S, AU - Sureja,Sunil, AU - Singh,Sachin, AU - Gurjar,Mitesh, AU - Jivani,N P, AU - Patel,Madhabhai M, Y1 - 2010/01/25/ PY - 2010/1/27/entrez PY - 2010/1/27/pubmed PY - 2011/7/21/medline SP - 146 EP - 51 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 16 IS - 2 N2 - The aim of the present study was to prepare and evaluate microspheres of Eudragit containing an antiviral drug stavudine. Microspheres were prepared by O/O solvent evaporation method using acetone/liquid paraffin system. The prepared microspheres were characterized for their micromeretic properties and entrapment efficiency; as well by Fourier transformed infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD) and scanning electron microscopy (SEM) which revealed the crystalline nature of drug in a final state. The in vitro studies revealed the controlled release of drug from microspheres up to 12 h and the best fit release kinetics was achieved with a Higuchi plot and found to be diffusion controlled. The yields of preparation and entrapment efficiencies were very high with a larger particle size for all the formulations. Mean particle size, entrapment efficiency and production yield were highly influenced by the type of polymer and polymer concentration. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/20100058/Design_characterization_and_in_vitro_evaluation_of_stavudine_loaded_microspheres_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837450903544559 DB - PRIME DP - Unbound Medicine ER -