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Antimutagenicity of some flowers grown in Thailand.
Food Chem Toxicol. 2010 Apr; 48(4):1045-51.FC

Abstract

The mutagenicity of dichloromethane, methanol and water extracts of Antigonon leptopus Hook. & Arn., Curcuma sessilis Gage, Hibiscus rosa-sinensis Linn., Ixora coccinea Linn., Millingtonia hortensis Linn., Nelumbo nucifera Gaertn., Plumeria obtusa Linn., Punica granatum Linn., Rhinacanthus nasutus ((Linn.) Kurz.) and Syzygium malaccense ((Linn.) Merr.& Perry) before and after nitrite treatment was firstly investigated in the Ames test. Their antimutagenicity against the product of the reaction mixture of 1-aminopyrene nitrite model in the absence of metabolic activation on Salmonella typhimurium TA 98 and TA 100 was evaluated. The results showed that none of the samples was mutagenic. Most nitrite-treated samples but dichloromethane extracts of Hibiscus rosa-sinensis, Plumeria obtusa, Syzygium malaccense, methanol extract of Syzygium malaccense and water extract of Hibiscus rosa-sinensis were mutagenic. The nitrite treated methanol extract of Nelumbo nucifera exhibited the highest mutagenicity on both strains. All dichloromethane extracts of flowers decreased the mutagenicity induced by the product of 1-aminopyrene nitrite model on both tester strains. Methanol extract of Curcuma sessilis and Punica granatum (15 mg/plate) showed the highest antimutagenic activity in TA 98 and TA 100, respectively. The protective effects of these flower extracts might be due to the presence of antimutagenic components that were supposed to be flavonoids.

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Authors+Show Affiliations

Wongwattanasathien O
Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phyathai Road, Bangkok 10330, Thailand.
Kangsadalampai K
No affiliation info available
Tongyonk L
No affiliation info available

MeSH

Antimutagenic AgentsBiotransformationFlowersHepatocytesMutagenicity TestsMutagensNitritesPlant ExtractsPlants, MedicinalPyrenesSalmonella typhimuriumSolventsThailand

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20100534

Citation

Wongwattanasathien, O, et al. "Antimutagenicity of some Flowers Grown in Thailand." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 48, no. 4, 2010, pp. 1045-51.
Wongwattanasathien O, Kangsadalampai K, Tongyonk L. Antimutagenicity of some flowers grown in Thailand. Food Chem Toxicol. 2010;48(4):1045-51.
Wongwattanasathien, O., Kangsadalampai, K., & Tongyonk, L. (2010). Antimutagenicity of some flowers grown in Thailand. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 48(4), 1045-51. https://doi.org/10.1016/j.fct.2010.01.018
Wongwattanasathien O, Kangsadalampai K, Tongyonk L. Antimutagenicity of some Flowers Grown in Thailand. Food Chem Toxicol. 2010;48(4):1045-51. PubMed PMID: 20100534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimutagenicity of some flowers grown in Thailand. AU - Wongwattanasathien,O, AU - Kangsadalampai,K, AU - Tongyonk,L, Y1 - 2010/01/25/ PY - 2009/09/18/received PY - 2010/01/12/revised PY - 2010/01/18/accepted PY - 2010/1/27/entrez PY - 2010/1/27/pubmed PY - 2010/5/26/medline SP - 1045 EP - 51 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 48 IS - 4 N2 - The mutagenicity of dichloromethane, methanol and water extracts of Antigonon leptopus Hook. & Arn., Curcuma sessilis Gage, Hibiscus rosa-sinensis Linn., Ixora coccinea Linn., Millingtonia hortensis Linn., Nelumbo nucifera Gaertn., Plumeria obtusa Linn., Punica granatum Linn., Rhinacanthus nasutus ((Linn.) Kurz.) and Syzygium malaccense ((Linn.) Merr.& Perry) before and after nitrite treatment was firstly investigated in the Ames test. Their antimutagenicity against the product of the reaction mixture of 1-aminopyrene nitrite model in the absence of metabolic activation on Salmonella typhimurium TA 98 and TA 100 was evaluated. The results showed that none of the samples was mutagenic. Most nitrite-treated samples but dichloromethane extracts of Hibiscus rosa-sinensis, Plumeria obtusa, Syzygium malaccense, methanol extract of Syzygium malaccense and water extract of Hibiscus rosa-sinensis were mutagenic. The nitrite treated methanol extract of Nelumbo nucifera exhibited the highest mutagenicity on both strains. All dichloromethane extracts of flowers decreased the mutagenicity induced by the product of 1-aminopyrene nitrite model on both tester strains. Methanol extract of Curcuma sessilis and Punica granatum (15 mg/plate) showed the highest antimutagenic activity in TA 98 and TA 100, respectively. The protective effects of these flower extracts might be due to the presence of antimutagenic components that were supposed to be flavonoids. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/20100534/Antimutagenicity_of_some_flowers_grown_in_Thailand_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(10)00070-0 DB - PRIME DP - Unbound Medicine ER -