Tags

Type your tag names separated by a space and hit enter

Microdialysis based device for continuous extravascular monitoring of blood glucose.
Biomed Microdevices. 2010 Jun; 12(3):399-407.BM

Abstract

Glycemic control of intensive care patients can be beneficial for this patient group but the continuous determination of their glucose concentration is challenging. Current continuous glucose monitoring systems based on the measurement of interstitial fluid glucose concentration struggle with sensitivity losses, resulting from biofouling or inflammation reactions. Their use as decision support systems for the therapeutic treatment is moreover hampered by physiological time delays as well as gradients in glucose concentration between plasma and interstitial fluid. To overcome these drawbacks, we developed and clinically evaluated a system based on microdialysis of whole blood. Venous blood is heparinised at the tip of a double lumen catheter and pumped through a membrane based micro-fluidic device where protein-free microdialysate samples are extracted. Glucose recovery as an indicator of long term stability was studied in vitro with heparinised bovine blood and remained highly stable for 72 h. Clinical performance was tested in a clinical trial in eight healthy volunteers undergoing an oral glucose tolerance test. Glucose concentrations of the new system and the reference method correlated at a level of 0.96 and their mean relative difference was 1.9 +/- 11.2%. Clinical evaluation using Clark's Error Grid analysis revealed that the obtained glucose concentrations were accurate and clinically acceptable in 99.6% of all cases. In conclusion, results of the technical and clinical evaluation suggest that the presented device delivers microdialysate samples suitable for accurate and long term stable continuous glucose monitoring in blood.

Authors+Show Affiliations

Institute of Medical Technologies and Health Management, Joanneum Research GmbH, Elisabethstrasse 11a, 8010, Graz, Austria. franz.feichtner@joanneum.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20101469

Citation

Feichtner, Franz, et al. "Microdialysis Based Device for Continuous Extravascular Monitoring of Blood Glucose." Biomedical Microdevices, vol. 12, no. 3, 2010, pp. 399-407.
Feichtner F, Schaller R, Fercher A, et al. Microdialysis based device for continuous extravascular monitoring of blood glucose. Biomed Microdevices. 2010;12(3):399-407.
Feichtner, F., Schaller, R., Fercher, A., Ratzer, M., Ellmerer, M., Plank, J., Krause, B., Pieber, T., & Schaupp, L. (2010). Microdialysis based device for continuous extravascular monitoring of blood glucose. Biomedical Microdevices, 12(3), 399-407. https://doi.org/10.1007/s10544-010-9396-3
Feichtner F, et al. Microdialysis Based Device for Continuous Extravascular Monitoring of Blood Glucose. Biomed Microdevices. 2010;12(3):399-407. PubMed PMID: 20101469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microdialysis based device for continuous extravascular monitoring of blood glucose. AU - Feichtner,Franz, AU - Schaller,Roland, AU - Fercher,Andreas, AU - Ratzer,Maria, AU - Ellmerer,Martin, AU - Plank,Johannes, AU - Krause,Bernd, AU - Pieber,Thomas, AU - Schaupp,Lukas, PY - 2010/1/27/entrez PY - 2010/1/27/pubmed PY - 2010/7/28/medline SP - 399 EP - 407 JF - Biomedical microdevices JO - Biomed Microdevices VL - 12 IS - 3 N2 - Glycemic control of intensive care patients can be beneficial for this patient group but the continuous determination of their glucose concentration is challenging. Current continuous glucose monitoring systems based on the measurement of interstitial fluid glucose concentration struggle with sensitivity losses, resulting from biofouling or inflammation reactions. Their use as decision support systems for the therapeutic treatment is moreover hampered by physiological time delays as well as gradients in glucose concentration between plasma and interstitial fluid. To overcome these drawbacks, we developed and clinically evaluated a system based on microdialysis of whole blood. Venous blood is heparinised at the tip of a double lumen catheter and pumped through a membrane based micro-fluidic device where protein-free microdialysate samples are extracted. Glucose recovery as an indicator of long term stability was studied in vitro with heparinised bovine blood and remained highly stable for 72 h. Clinical performance was tested in a clinical trial in eight healthy volunteers undergoing an oral glucose tolerance test. Glucose concentrations of the new system and the reference method correlated at a level of 0.96 and their mean relative difference was 1.9 +/- 11.2%. Clinical evaluation using Clark's Error Grid analysis revealed that the obtained glucose concentrations were accurate and clinically acceptable in 99.6% of all cases. In conclusion, results of the technical and clinical evaluation suggest that the presented device delivers microdialysate samples suitable for accurate and long term stable continuous glucose monitoring in blood. SN - 1572-8781 UR - https://www.unboundmedicine.com/medline/citation/20101469/Microdialysis_based_device_for_continuous_extravascular_monitoring_of_blood_glucose_ L2 - https://doi.org/10.1007/s10544-010-9396-3 DB - PRIME DP - Unbound Medicine ER -