Tags

Type your tag names separated by a space and hit enter

Ultra-rapid opiate detoxification followed by nine months of naltrexone maintenance therapy in Iran.
Pharmacopsychiatry. 2010 Jun; 43(4):130-7.P

Abstract

INTRODUCTION

The aim of this retrospective study was to assess ultra-rapid opiate detoxification (UROD) and to estimate the retention rate in naltrexone maintenance treatment.

METHODS

45 opiate-addicted male patients (DSM-IV 304.00; opiate per oral or per inhalation n=40, heroin intravenous n=5; concomitant cannabis abuse n=6) were detoxified by 6 h of naloxone infusion under general anesthesia with midazolam, propofol, clonidine and atracurium. Withdrawal signs were evaluated by the objective opiate withdrawal scale (OOWS, range 0-13) up to 24 h after awakening. After UROD, naltrexone 50 mg/day was prescribed for 9 months with assessments in 4-week intervals.

RESULTS

Adverse events after UROD were prolonged unconsciousness (n=1), transient confusion (n=8) and depressive mood (n=6). The total sample showed a median OOWS score of 2 (mild withdrawal syndrome). The only two extreme outliers were found only in the subgroups "intravenous" (score 8) and "cannabis" (score 11). 96% (43/45) of the patients could be discharged the day after UROD. Thirty-six patients (80%) continued naltrexone therapy for the entire 9-month observation period.

DISCUSSION

UROD and subsequently induction of naltrexone maintenance therapy can be regarded as safe and effective in patients with pure opiate addiction. Owing to cultural and economical factors our Iranian results may not correspond to European and American treatment modalities.

Authors+Show Affiliations

Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria. angela.naderi-heiden@meduniwien.ac.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20101570

Citation

Naderi-Heiden, A, et al. "Ultra-rapid Opiate Detoxification Followed By Nine Months of Naltrexone Maintenance Therapy in Iran." Pharmacopsychiatry, vol. 43, no. 4, 2010, pp. 130-7.
Naderi-Heiden A, Naderi A, Naderi MM, et al. Ultra-rapid opiate detoxification followed by nine months of naltrexone maintenance therapy in Iran. Pharmacopsychiatry. 2010;43(4):130-7.
Naderi-Heiden, A., Naderi, A., Naderi, M. M., Rahmani-Didar, F., Salimi, A. R., Gleiss, A., Kasper, S., & Frey, R. (2010). Ultra-rapid opiate detoxification followed by nine months of naltrexone maintenance therapy in Iran. Pharmacopsychiatry, 43(4), 130-7. https://doi.org/10.1055/s-0029-1242820
Naderi-Heiden A, et al. Ultra-rapid Opiate Detoxification Followed By Nine Months of Naltrexone Maintenance Therapy in Iran. Pharmacopsychiatry. 2010;43(4):130-7. PubMed PMID: 20101570.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultra-rapid opiate detoxification followed by nine months of naltrexone maintenance therapy in Iran. AU - Naderi-Heiden,A, AU - Naderi,A, AU - Naderi,M M, AU - Rahmani-Didar,F, AU - Salimi,A-R, AU - Gleiss,A, AU - Kasper,S, AU - Frey,R, Y1 - 2010/01/25/ PY - 2010/1/27/entrez PY - 2010/1/27/pubmed PY - 2010/9/24/medline SP - 130 EP - 7 JF - Pharmacopsychiatry JO - Pharmacopsychiatry VL - 43 IS - 4 N2 - INTRODUCTION: The aim of this retrospective study was to assess ultra-rapid opiate detoxification (UROD) and to estimate the retention rate in naltrexone maintenance treatment. METHODS: 45 opiate-addicted male patients (DSM-IV 304.00; opiate per oral or per inhalation n=40, heroin intravenous n=5; concomitant cannabis abuse n=6) were detoxified by 6 h of naloxone infusion under general anesthesia with midazolam, propofol, clonidine and atracurium. Withdrawal signs were evaluated by the objective opiate withdrawal scale (OOWS, range 0-13) up to 24 h after awakening. After UROD, naltrexone 50 mg/day was prescribed for 9 months with assessments in 4-week intervals. RESULTS: Adverse events after UROD were prolonged unconsciousness (n=1), transient confusion (n=8) and depressive mood (n=6). The total sample showed a median OOWS score of 2 (mild withdrawal syndrome). The only two extreme outliers were found only in the subgroups "intravenous" (score 8) and "cannabis" (score 11). 96% (43/45) of the patients could be discharged the day after UROD. Thirty-six patients (80%) continued naltrexone therapy for the entire 9-month observation period. DISCUSSION: UROD and subsequently induction of naltrexone maintenance therapy can be regarded as safe and effective in patients with pure opiate addiction. Owing to cultural and economical factors our Iranian results may not correspond to European and American treatment modalities. SN - 1439-0795 UR - https://www.unboundmedicine.com/medline/citation/20101570/Ultra_rapid_opiate_detoxification_followed_by_nine_months_of_naltrexone_maintenance_therapy_in_Iran_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0029-1242820 DB - PRIME DP - Unbound Medicine ER -