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Protective effect of sesamol against 3-nitropropionic acid-induced cognitive dysfunction and altered glutathione redox balance in rats.
Basic Clin Pharmacol Toxicol. 2010 Jul; 107(1):577-82.BC

Abstract

Sesamol (SML) (Sesamum indicum, Linn, Pedaliaceae) has been used traditionally as a health supplement in India and other countries for a long time. It is a well-known antioxidant, currently being tried against several neurological disorders. The present study was designed to evaluate the potential of sesamol treatment against 3-nitropropionic acid (3-NP)-induced cognitive impairment and oxidative damage in striatal, cortex and hippocampal regions of the rat. The memory performance was assessed by Morris water maze and elevated plus maze paradigms. The oxidative damage was assessed by estimating the total glutathione, reduced glutathione, oxidized glutathione levels and glutathione redox ratio. Glutathione-S-transferase and lactate dehydrogenase enzymes were also measured in different brain areas. 3-NP significantly impaired memory performance as assessed in Morris water maze and elevated plus maze, which was significantly attenuated by sesamol (5, 10 and 20 mg/kg) pre-treatment. On the other hand, 3-NP significantly induced oxidative stress and depleted total glutathione, reduced glutathione, glutathione-S-transferase, lactate dehydrogenase enzyme levels and redox ratio in the striatum, cortex and hippocampal regions as compared to the vehicle-treated group. Sesamol pre-treatment restored oxidative defence possibly by its free radical scavenging activity as compared to the 3NP-treated group. The present study suggests that sesamol could be used as an effective agent in the management of Huntington's disease.

Authors+Show Affiliations

Pharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20102363

Citation

Kumar, Puneet, et al. "Protective Effect of Sesamol Against 3-nitropropionic Acid-induced Cognitive Dysfunction and Altered Glutathione Redox Balance in Rats." Basic & Clinical Pharmacology & Toxicology, vol. 107, no. 1, 2010, pp. 577-82.
Kumar P, Kalonia H, Kumar A. Protective effect of sesamol against 3-nitropropionic acid-induced cognitive dysfunction and altered glutathione redox balance in rats. Basic Clin Pharmacol Toxicol. 2010;107(1):577-82.
Kumar, P., Kalonia, H., & Kumar, A. (2010). Protective effect of sesamol against 3-nitropropionic acid-induced cognitive dysfunction and altered glutathione redox balance in rats. Basic & Clinical Pharmacology & Toxicology, 107(1), 577-82. https://doi.org/10.1111/j.1742-7843.2010.00537.x
Kumar P, Kalonia H, Kumar A. Protective Effect of Sesamol Against 3-nitropropionic Acid-induced Cognitive Dysfunction and Altered Glutathione Redox Balance in Rats. Basic Clin Pharmacol Toxicol. 2010;107(1):577-82. PubMed PMID: 20102363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of sesamol against 3-nitropropionic acid-induced cognitive dysfunction and altered glutathione redox balance in rats. AU - Kumar,Puneet, AU - Kalonia,Harikesh, AU - Kumar,Anil, Y1 - 2010/01/25/ PY - 2010/1/28/entrez PY - 2010/1/28/pubmed PY - 2010/10/13/medline SP - 577 EP - 82 JF - Basic & clinical pharmacology & toxicology JO - Basic Clin Pharmacol Toxicol VL - 107 IS - 1 N2 - Sesamol (SML) (Sesamum indicum, Linn, Pedaliaceae) has been used traditionally as a health supplement in India and other countries for a long time. It is a well-known antioxidant, currently being tried against several neurological disorders. The present study was designed to evaluate the potential of sesamol treatment against 3-nitropropionic acid (3-NP)-induced cognitive impairment and oxidative damage in striatal, cortex and hippocampal regions of the rat. The memory performance was assessed by Morris water maze and elevated plus maze paradigms. The oxidative damage was assessed by estimating the total glutathione, reduced glutathione, oxidized glutathione levels and glutathione redox ratio. Glutathione-S-transferase and lactate dehydrogenase enzymes were also measured in different brain areas. 3-NP significantly impaired memory performance as assessed in Morris water maze and elevated plus maze, which was significantly attenuated by sesamol (5, 10 and 20 mg/kg) pre-treatment. On the other hand, 3-NP significantly induced oxidative stress and depleted total glutathione, reduced glutathione, glutathione-S-transferase, lactate dehydrogenase enzyme levels and redox ratio in the striatum, cortex and hippocampal regions as compared to the vehicle-treated group. Sesamol pre-treatment restored oxidative defence possibly by its free radical scavenging activity as compared to the 3NP-treated group. The present study suggests that sesamol could be used as an effective agent in the management of Huntington's disease. SN - 1742-7843 UR - https://www.unboundmedicine.com/medline/citation/20102363/Protective_effect_of_sesamol_against_3_nitropropionic_acid_induced_cognitive_dysfunction_and_altered_glutathione_redox_balance_in_rats_ L2 - https://doi.org/10.1111/j.1742-7843.2010.00537.x DB - PRIME DP - Unbound Medicine ER -