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Whole-grain ready-to-eat oat cereal, as part of a dietary program for weight loss, reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low-fiber control foods.
J Am Diet Assoc 2010; 110(2):205-14JA

Abstract

OBJECTIVE

Weight loss and consumption of viscous fibers both lower low-density lipoprotein (LDL) cholesterol levels. We evaluated whether or not a whole-grain, ready-to-eat (RTE) oat cereal containing viscous fiber, as part of a dietary program for weight loss, lowers LDL cholesterol levels and improves other cardiovascular disease risk markers more than a dietary program alone.

DESIGN

Randomized, parallel-arm, controlled trial.

SUBJECTS/SETTING

Free-living, overweight and obese adults (N=204, body mass index 25 to 45) with baseline LDL cholesterol levels 130 to 200 mg/dL (3.4 to 5.2 mmol/L) were randomized; 144 were included in the main analysis of participants who completed the trial without significant protocol violations.

INTERVENTION

Two portions per day of whole-grain RTE oat cereal (3 g/day oat b-glucan) or energy-matched low-fiber foods (control), as part of a reduced energy (approximately 500 kcal/day deficit) dietary program that encouraged limiting consumption of foods high in energy and fat, portion control, and regular physical activity.

MAIN OUTCOME MEASURES

Fasting lipoprotein levels, waist circumference, triceps skinfold thickness, and body weight were measured at baseline and weeks 4, 8, 10, and 12.

RESULTS

LDL cholesterol level was reduced significantly more with whole-grain RTE oat cereal vs control (-8.7+/-1.0 vs -4.3+/-1.1%, P=0.005). Total cholesterol (-5.4+/-0.8 vs -2.9+/-0.9%, P=0.038) and non-high-density lipoprotein-cholesterol (-6.3+/-1.0 vs -3.3+/-1.1%, P=0.046) were also lowered significantly more with whole-grain RTE oat cereal, whereas high-density lipoprotein and triglyceride responses did not differ between groups. Weight loss was not different between groups (-2.2+/-0.3 vs -1.7+/-0.3 kg, P=0.325), but waist circumference decreased more (-3.3+/-0.4 vs -1.9+/-0.4 cm, P=0.012) with whole-grain RTE oat cereal. Larger reductions in LDL, total, and non-high-density lipoprotein cholesterol levels and waist circumference were evident as early as week 4 in the whole-grain RTE oat cereal group.

CONCLUSIONS

Consumption of a whole-grain RTE oat cereal as part of a dietary program for weight loss had favorable effects on fasting lipid levels and waist circumference.

Authors+Show Affiliations

Provident Clinical Research, Glen Ellyn, IL 60137, USA. KMaki@ProvidentCRC.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20102847

Citation

Maki, Kevin C., et al. "Whole-grain Ready-to-eat Oat Cereal, as Part of a Dietary Program for Weight Loss, Reduces Low-density Lipoprotein Cholesterol in Adults With Overweight and Obesity More Than a Dietary Program Including Low-fiber Control Foods." Journal of the American Dietetic Association, vol. 110, no. 2, 2010, pp. 205-14.
Maki KC, Beiseigel JM, Jonnalagadda SS, et al. Whole-grain ready-to-eat oat cereal, as part of a dietary program for weight loss, reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low-fiber control foods. J Am Diet Assoc. 2010;110(2):205-14.
Maki, K. C., Beiseigel, J. M., Jonnalagadda, S. S., Gugger, C. K., Reeves, M. S., Farmer, M. V., ... Rains, T. M. (2010). Whole-grain ready-to-eat oat cereal, as part of a dietary program for weight loss, reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low-fiber control foods. Journal of the American Dietetic Association, 110(2), pp. 205-14. doi:10.1016/j.jada.2009.10.037.
Maki KC, et al. Whole-grain Ready-to-eat Oat Cereal, as Part of a Dietary Program for Weight Loss, Reduces Low-density Lipoprotein Cholesterol in Adults With Overweight and Obesity More Than a Dietary Program Including Low-fiber Control Foods. J Am Diet Assoc. 2010;110(2):205-14. PubMed PMID: 20102847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Whole-grain ready-to-eat oat cereal, as part of a dietary program for weight loss, reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low-fiber control foods. AU - Maki,Kevin C, AU - Beiseigel,Jeannemarie M, AU - Jonnalagadda,Satya S, AU - Gugger,Carolyn K, AU - Reeves,Matthew S, AU - Farmer,Mildred V, AU - Kaden,Valerie N, AU - Rains,Tia M, PY - 2009/05/19/received PY - 2009/07/31/accepted PY - 2010/1/28/entrez PY - 2010/1/28/pubmed PY - 2010/2/16/medline SP - 205 EP - 14 JF - Journal of the American Dietetic Association JO - J Am Diet Assoc VL - 110 IS - 2 N2 - OBJECTIVE: Weight loss and consumption of viscous fibers both lower low-density lipoprotein (LDL) cholesterol levels. We evaluated whether or not a whole-grain, ready-to-eat (RTE) oat cereal containing viscous fiber, as part of a dietary program for weight loss, lowers LDL cholesterol levels and improves other cardiovascular disease risk markers more than a dietary program alone. DESIGN: Randomized, parallel-arm, controlled trial. SUBJECTS/SETTING: Free-living, overweight and obese adults (N=204, body mass index 25 to 45) with baseline LDL cholesterol levels 130 to 200 mg/dL (3.4 to 5.2 mmol/L) were randomized; 144 were included in the main analysis of participants who completed the trial without significant protocol violations. INTERVENTION: Two portions per day of whole-grain RTE oat cereal (3 g/day oat b-glucan) or energy-matched low-fiber foods (control), as part of a reduced energy (approximately 500 kcal/day deficit) dietary program that encouraged limiting consumption of foods high in energy and fat, portion control, and regular physical activity. MAIN OUTCOME MEASURES: Fasting lipoprotein levels, waist circumference, triceps skinfold thickness, and body weight were measured at baseline and weeks 4, 8, 10, and 12. RESULTS: LDL cholesterol level was reduced significantly more with whole-grain RTE oat cereal vs control (-8.7+/-1.0 vs -4.3+/-1.1%, P=0.005). Total cholesterol (-5.4+/-0.8 vs -2.9+/-0.9%, P=0.038) and non-high-density lipoprotein-cholesterol (-6.3+/-1.0 vs -3.3+/-1.1%, P=0.046) were also lowered significantly more with whole-grain RTE oat cereal, whereas high-density lipoprotein and triglyceride responses did not differ between groups. Weight loss was not different between groups (-2.2+/-0.3 vs -1.7+/-0.3 kg, P=0.325), but waist circumference decreased more (-3.3+/-0.4 vs -1.9+/-0.4 cm, P=0.012) with whole-grain RTE oat cereal. Larger reductions in LDL, total, and non-high-density lipoprotein cholesterol levels and waist circumference were evident as early as week 4 in the whole-grain RTE oat cereal group. CONCLUSIONS: Consumption of a whole-grain RTE oat cereal as part of a dietary program for weight loss had favorable effects on fasting lipid levels and waist circumference. SN - 1878-3570 UR - https://www.unboundmedicine.com/medline/citation/20102847/Whole_grain_ready_to_eat_oat_cereal_as_part_of_a_dietary_program_for_weight_loss_reduces_low_density_lipoprotein_cholesterol_in_adults_with_overweight_and_obesity_more_than_a_dietary_program_including_low_fiber_control_foods_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8223(09)01813-6 DB - PRIME DP - Unbound Medicine ER -