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Prognostic value of tissue Doppler right ventricular systolic and diastolic function indexes combined with plasma B-type natriuretic Peptide in patients with advanced heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.
Am J Cardiol. 2010 Jan 15; 105(2):249-54.AJ

Abstract

Right ventricular (RV) dysfunction adversely affects prognosis in patients with chronic heart failure (CHF) due to left ventricular (LV) dysfunction. However, little evidence exists regarding the prognostic role of RV systolic and diastolic function indexes in combination with plasma B-type natriuretic peptide (BNP) in advanced CHF. Thus, 102 consecutive hospitalized patients with advanced CHF (New York Heart Association classes III to IV) due to LV systolic dysfunction (LV ejection fraction <35%) were studied by 2-dimensional conventional and tissue Doppler imaging (TDI) echocardiography of the left and right ventricles. Plasma BNP was also measured. Patients were followed for 6 months for major cardiovascular events (cardiovascular death and/or CHF-related hospitalization). During follow-up, 13 patients died and 63 patients reached the combined end point of cardiovascular death or CHF-related hospitalization. By univariate analysis, RV TDI systolic velocity, dilated cardiomyopathy, digoxin treatment (all p values <0.01), and female gender (p <0.05) were associated with increased cardiovascular death. Transmitral Doppler to mitral annular TDI early diastolic velocity ratio, RV TDI early diastolic velocity (p <0.05), and ratio of early to late RV diastolic TDI velocities (p <0.01) predicted the combined end point. In multivariate analysis, decreased RV systolic velocity, dilated cardiomyopathy, and female gender (all p values <0.05) were independent predictors of cardiovascular death, whereas increased ratio of early to late RV diastolic TDI velocities (p <0.01) and increased BNP (p <0.05) predicted the combined end point. In conclusion, RV TDI indexes combined with increased plasma BNP additively predict adverse cardiac outcomes in advanced CHF.

Authors+Show Affiliations

Second Department of Cardiology and Heart Failure Unit, Attikon University Hospital, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

20102927

Citation

Bistola, Vasiliki, et al. "Prognostic Value of Tissue Doppler Right Ventricular Systolic and Diastolic Function Indexes Combined With Plasma B-type Natriuretic Peptide in Patients With Advanced Heart Failure Secondary to Ischemic or Idiopathic Dilated Cardiomyopathy." The American Journal of Cardiology, vol. 105, no. 2, 2010, pp. 249-54.
Bistola V, Parissis JT, Paraskevaidis I, et al. Prognostic value of tissue Doppler right ventricular systolic and diastolic function indexes combined with plasma B-type natriuretic Peptide in patients with advanced heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 2010;105(2):249-54.
Bistola, V., Parissis, J. T., Paraskevaidis, I., Panou, F., Nikolaou, M., Ikonomidis, I., Flessas, N., Filippatos, G., Iliodromitis, E., & Kremastinos, D. T. (2010). Prognostic value of tissue Doppler right ventricular systolic and diastolic function indexes combined with plasma B-type natriuretic Peptide in patients with advanced heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. The American Journal of Cardiology, 105(2), 249-54. https://doi.org/10.1016/j.amjcard.2009.08.682
Bistola V, et al. Prognostic Value of Tissue Doppler Right Ventricular Systolic and Diastolic Function Indexes Combined With Plasma B-type Natriuretic Peptide in Patients With Advanced Heart Failure Secondary to Ischemic or Idiopathic Dilated Cardiomyopathy. Am J Cardiol. 2010 Jan 15;105(2):249-54. PubMed PMID: 20102927.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic value of tissue Doppler right ventricular systolic and diastolic function indexes combined with plasma B-type natriuretic Peptide in patients with advanced heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. AU - Bistola,Vasiliki, AU - Parissis,John T, AU - Paraskevaidis,Ioannis, AU - Panou,Fotios, AU - Nikolaou,Maria, AU - Ikonomidis,Ignatios, AU - Flessas,Nikolaos, AU - Filippatos,Gerasimos, AU - Iliodromitis,Efstathios, AU - Kremastinos,Dimitrios T, PY - 2009/07/08/received PY - 2009/08/25/revised PY - 2009/08/25/accepted PY - 2010/1/28/entrez PY - 2010/1/28/pubmed PY - 2010/2/26/medline SP - 249 EP - 54 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 105 IS - 2 N2 - Right ventricular (RV) dysfunction adversely affects prognosis in patients with chronic heart failure (CHF) due to left ventricular (LV) dysfunction. However, little evidence exists regarding the prognostic role of RV systolic and diastolic function indexes in combination with plasma B-type natriuretic peptide (BNP) in advanced CHF. Thus, 102 consecutive hospitalized patients with advanced CHF (New York Heart Association classes III to IV) due to LV systolic dysfunction (LV ejection fraction <35%) were studied by 2-dimensional conventional and tissue Doppler imaging (TDI) echocardiography of the left and right ventricles. Plasma BNP was also measured. Patients were followed for 6 months for major cardiovascular events (cardiovascular death and/or CHF-related hospitalization). During follow-up, 13 patients died and 63 patients reached the combined end point of cardiovascular death or CHF-related hospitalization. By univariate analysis, RV TDI systolic velocity, dilated cardiomyopathy, digoxin treatment (all p values <0.01), and female gender (p <0.05) were associated with increased cardiovascular death. Transmitral Doppler to mitral annular TDI early diastolic velocity ratio, RV TDI early diastolic velocity (p <0.05), and ratio of early to late RV diastolic TDI velocities (p <0.01) predicted the combined end point. In multivariate analysis, decreased RV systolic velocity, dilated cardiomyopathy, and female gender (all p values <0.05) were independent predictors of cardiovascular death, whereas increased ratio of early to late RV diastolic TDI velocities (p <0.01) and increased BNP (p <0.05) predicted the combined end point. In conclusion, RV TDI indexes combined with increased plasma BNP additively predict adverse cardiac outcomes in advanced CHF. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/20102927/Prognostic_value_of_tissue_Doppler_right_ventricular_systolic_and_diastolic_function_indexes_combined_with_plasma_B_type_natriuretic_Peptide_in_patients_with_advanced_heart_failure_secondary_to_ischemic_or_idiopathic_dilated_cardiomyopathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(09)02336-4 DB - PRIME DP - Unbound Medicine ER -