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IGFBP2 and IGFBP3 protein expressions in human breast cancer: association with hormonal factors and obesity.
Clin Cancer Res. 2010 Feb 01; 16(3):1025-32.CC

Abstract

PURPOSE

The insulin-like growth factor (IGF) signaling system is involved in breast cancer initiation and progression. The prognostic relevance of tumor expression patterns of IGFI-related proteins remains poorly understood. This study associates the expression of selected IGF proteins with breast tumor and patient characteristics.

EXPERIMENTAL DESIGN

IGFI, IGFI receptor, IGF-binding protein (IGFBP)2, and IGFBP3 expression was measured in 855 primary breast carcinomas by immunohistochemistry using tissue microarrays. We investigated the association of tumor and nodal stage, grade, hormone receptor status, HER2 gene amplification, menopausal status, body mass index, and survival with IGF protein expression.

RESULTS

In contrast to IGFI, the expression of IGFI receptor, IGFBP2, and IGFBP3 was associated with estrogen receptor status. In addition, IGFBP3 was positively correlated with body mass index and premenopausal status. Importantly, IGFBP2 was an independent and positive predictor of overall survival (hazard ratio, 0.48; 95% confidence interval, 0.24-0.95; P = 0.04). There was a weak suggestion for IGFBP2 and overweight to modify each other's effect on survival.

CONCLUSIONS

According to these results, which need confirmation in larger patient series, the prognostic relevance of IGFBP2 and IGFBP3 protein expressions in breast cancer may depend on the hormonal context and body weight.

Authors+Show Affiliations

Institute of Social and Preventive Medicine, University of Zurich, Zurich. Nicole.Probst@unibas.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20103684

Citation

Probst-Hensch, Nicole M., et al. "IGFBP2 and IGFBP3 Protein Expressions in Human Breast Cancer: Association With Hormonal Factors and Obesity." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, vol. 16, no. 3, 2010, pp. 1025-32.
Probst-Hensch NM, Steiner JH, Schraml P, et al. IGFBP2 and IGFBP3 protein expressions in human breast cancer: association with hormonal factors and obesity. Clin Cancer Res. 2010;16(3):1025-32.
Probst-Hensch, N. M., Steiner, J. H., Schraml, P., Varga, Z., Zürrer-Härdi, U., Storz, M., Korol, D., Fehr, M. K., Fink, D., Pestalozzi, B. C., Lütolf, U. M., Theurillat, J. P., & Moch, H. (2010). IGFBP2 and IGFBP3 protein expressions in human breast cancer: association with hormonal factors and obesity. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 16(3), 1025-32. https://doi.org/10.1158/1078-0432.CCR-09-0957
Probst-Hensch NM, et al. IGFBP2 and IGFBP3 Protein Expressions in Human Breast Cancer: Association With Hormonal Factors and Obesity. Clin Cancer Res. 2010 Feb 1;16(3):1025-32. PubMed PMID: 20103684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IGFBP2 and IGFBP3 protein expressions in human breast cancer: association with hormonal factors and obesity. AU - Probst-Hensch,Nicole M, AU - Steiner,Julia H B, AU - Schraml,Peter, AU - Varga,Zsuzsanna, AU - Zürrer-Härdi,Ursina, AU - Storz,Martina, AU - Korol,Dimitri, AU - Fehr,Mathias K, AU - Fink,Daniel, AU - Pestalozzi,Bernhard C, AU - Lütolf,Urs M, AU - Theurillat,Jean-Philippe, AU - Moch,Holger, Y1 - 2010/01/26/ PY - 2010/1/28/entrez PY - 2010/1/28/pubmed PY - 2010/4/23/medline SP - 1025 EP - 32 JF - Clinical cancer research : an official journal of the American Association for Cancer Research JO - Clin Cancer Res VL - 16 IS - 3 N2 - PURPOSE: The insulin-like growth factor (IGF) signaling system is involved in breast cancer initiation and progression. The prognostic relevance of tumor expression patterns of IGFI-related proteins remains poorly understood. This study associates the expression of selected IGF proteins with breast tumor and patient characteristics. EXPERIMENTAL DESIGN: IGFI, IGFI receptor, IGF-binding protein (IGFBP)2, and IGFBP3 expression was measured in 855 primary breast carcinomas by immunohistochemistry using tissue microarrays. We investigated the association of tumor and nodal stage, grade, hormone receptor status, HER2 gene amplification, menopausal status, body mass index, and survival with IGF protein expression. RESULTS: In contrast to IGFI, the expression of IGFI receptor, IGFBP2, and IGFBP3 was associated with estrogen receptor status. In addition, IGFBP3 was positively correlated with body mass index and premenopausal status. Importantly, IGFBP2 was an independent and positive predictor of overall survival (hazard ratio, 0.48; 95% confidence interval, 0.24-0.95; P = 0.04). There was a weak suggestion for IGFBP2 and overweight to modify each other's effect on survival. CONCLUSIONS: According to these results, which need confirmation in larger patient series, the prognostic relevance of IGFBP2 and IGFBP3 protein expressions in breast cancer may depend on the hormonal context and body weight. SN - 1078-0432 UR - https://www.unboundmedicine.com/medline/citation/20103684/IGFBP2_and_IGFBP3_protein_expressions_in_human_breast_cancer:_association_with_hormonal_factors_and_obesity_ L2 - http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=20103684 DB - PRIME DP - Unbound Medicine ER -