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Hepatotoxicity due to hydroxycut: a case series.

Abstract

OBJECTIVES

Muscletech Hydroxycut (Iovate Health Sciences Research, Oakville, Ontario, Canada) was a popular weight-loss supplement that was recalled by the manufacturer in May 2009 on the basis of reports of hepatotoxicity associated with this supplement. We sought to characterize the clinical presentation of Hydroxycut-associated liver injury and to adjudicate these cases for causal association with Hydroxycut.

METHODS

We assessed the causality and grading of severity of liver injury using methodology developed by the Drug-Induced Liver Injury Network (DILIN) study.

RESULTS

Eight patients who developed liver injury after taking Hydroxycut treated at different medical centers were identified. All were hospitalized, and three of eight patients required liver transplantation. Nine other cases with adequate clinical information were obtained from the FDA MedWatch database, including one fatal case of acute liver failure. Usual symptoms were jaundice, fatigue, nausea, vomiting, and abdominal pain. Most patients exhibited a hepatocellular pattern of injury. Adjudication for causality revealed eight cases as definite, five highly likely, two probable, and two were considered to be possible.

CONCLUSIONS

Hydroxycut has been clearly implicated as a cause for severe liver injury that may lead to acute liver failure and death. Weight-loss supplements represent a class of dietary supplements that should be regarded as capable of causing severe hepatic toxicity when the usual causes of identified liver injury cannot be otherwise elucidated.

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  • Authors+Show Affiliations

    ,

    Division of Gastrointestinal and Liver Diseases, University of Southern California, Keck School of Medicine, 1510 San Pablo Street, 2/F, Los Angeles, CA 90033, USA. tselingf@usc.edu

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    Source

    MeSH

    Adolescent
    Adult
    Anti-Obesity Agents
    Chemical and Drug Induced Liver Injury
    Dietary Supplements
    Female
    Humans
    Liver Transplantation
    Male
    Middle Aged
    Plant Preparations
    Severity of Illness Index

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    20104221

    Citation

    Fong, Tse-Ling, et al. "Hepatotoxicity Due to Hydroxycut: a Case Series." The American Journal of Gastroenterology, vol. 105, no. 7, 2010, pp. 1561-6.
    Fong TL, Klontz KC, Canas-Coto A, et al. Hepatotoxicity due to hydroxycut: a case series. Am J Gastroenterol. 2010;105(7):1561-6.
    Fong, T. L., Klontz, K. C., Canas-Coto, A., Casper, S. J., Durazo, F. A., Davern, T. J., ... Seeff, L. B. (2010). Hepatotoxicity due to hydroxycut: a case series. The American Journal of Gastroenterology, 105(7), pp. 1561-6. doi:10.1038/ajg.2010.5.
    Fong TL, et al. Hepatotoxicity Due to Hydroxycut: a Case Series. Am J Gastroenterol. 2010;105(7):1561-6. PubMed PMID: 20104221.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hepatotoxicity due to hydroxycut: a case series. AU - Fong,Tse-Ling, AU - Klontz,Karl C, AU - Canas-Coto,Alejandro, AU - Casper,Steven J, AU - Durazo,Francisco A, AU - Davern,Timothy J,2nd AU - Hayashi,Paul, AU - Lee,William M, AU - Seeff,Leonard B, Y1 - 2010/01/26/ PY - 2010/1/28/entrez PY - 2010/1/28/pubmed PY - 2010/8/14/medline SP - 1561 EP - 6 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 105 IS - 7 N2 - OBJECTIVES: Muscletech Hydroxycut (Iovate Health Sciences Research, Oakville, Ontario, Canada) was a popular weight-loss supplement that was recalled by the manufacturer in May 2009 on the basis of reports of hepatotoxicity associated with this supplement. We sought to characterize the clinical presentation of Hydroxycut-associated liver injury and to adjudicate these cases for causal association with Hydroxycut. METHODS: We assessed the causality and grading of severity of liver injury using methodology developed by the Drug-Induced Liver Injury Network (DILIN) study. RESULTS: Eight patients who developed liver injury after taking Hydroxycut treated at different medical centers were identified. All were hospitalized, and three of eight patients required liver transplantation. Nine other cases with adequate clinical information were obtained from the FDA MedWatch database, including one fatal case of acute liver failure. Usual symptoms were jaundice, fatigue, nausea, vomiting, and abdominal pain. Most patients exhibited a hepatocellular pattern of injury. Adjudication for causality revealed eight cases as definite, five highly likely, two probable, and two were considered to be possible. CONCLUSIONS: Hydroxycut has been clearly implicated as a cause for severe liver injury that may lead to acute liver failure and death. Weight-loss supplements represent a class of dietary supplements that should be regarded as capable of causing severe hepatic toxicity when the usual causes of identified liver injury cannot be otherwise elucidated. SN - 1572-0241 UR - https://www.unboundmedicine.com/medline/citation/20104221/Hepatotoxicity_due_to_hydroxycut:_a_case_series_ L2 - http://Insights.ovid.com/pubmed?pmid=20104221 DB - PRIME DP - Unbound Medicine ER -