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Antioxidant nutrient intakes and corresponding biomarkers associated with the risk of atopic dermatitis in young children.
Eur J Clin Nutr 2010; 64(3):245-52EJ

Abstract

BACKGROUND/OBJECTIVES

To investigate the association of antioxidant nutritional status with the risk of atopic dermatitis (AD) in young children in a case-control, population-based study.

SUBJECTS/METHODS

Identified from preschools by using the Korean version of the International Study of Asthma and Allergies in Childhood (ISAAC). Final analysis included 180 AD (mean age 5.3+/-0.9 years) and 242 non-AD (mean age 5.2+/-1.0 years) children. Diet was assessed using a validated semi-quantitative food frequency questionnaire. Fasting blood samples were used for analyses of fat-soluble vitamins (retinol, alpha-tocopherol, and beta-carotene) and vitamin C.

RESULTS

AD was associated negatively with intakes of antioxidant-related nutrients. The adjusted odds ratio (OR) and 95% confidence interval (95% CI) were 0.44 (0.22-0.88) for the highest (vs lowest) quintile of beta-carotene. A similar association was observed for dietary vitamin E (OR=0.33, 95% CI=0.16-0.67), folic acid (OR=0.37, 95% CI=0.18-0.73), and iron (OR=0.39, 95% CI=0.19-0.79). Reduced AD risk was found with 1 s.d. increase of serum alpha-tocopherol [OR=0.64, 95% CI=0.41-0.98) and retinol (OR=0.74, 95% CI=0.58-0.96) concentrations, and marginally with that of serum beta-carotene levels (P=0.0749 for trend). There was no relationship of AD risk with dietary and plasma vitamin C as well as nutrient supplement intake regardless of nutrient type. AD was predicted better by the intake measure than the corresponding blood biomarker regarding vitamin E and beta-carotene.

CONCLUSIONS

These findings suggest that higher antioxidant nutritional status reduces the risk of AD and that such risk-reduction effects depend on nutrient type.

Authors+Show Affiliations

Department of Food and Nutrition, College of Human Ecology, Kyung Hee University, Seoul, Republic of Korea. seyoung@khu.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20104235

Citation

Oh, S-Y, et al. "Antioxidant Nutrient Intakes and Corresponding Biomarkers Associated With the Risk of Atopic Dermatitis in Young Children." European Journal of Clinical Nutrition, vol. 64, no. 3, 2010, pp. 245-52.
Oh SY, Chung J, Kim MK, et al. Antioxidant nutrient intakes and corresponding biomarkers associated with the risk of atopic dermatitis in young children. Eur J Clin Nutr. 2010;64(3):245-52.
Oh, S. Y., Chung, J., Kim, M. K., Kwon, S. O., & Cho, B. H. (2010). Antioxidant nutrient intakes and corresponding biomarkers associated with the risk of atopic dermatitis in young children. European Journal of Clinical Nutrition, 64(3), pp. 245-52. doi:10.1038/ejcn.2009.148.
Oh SY, et al. Antioxidant Nutrient Intakes and Corresponding Biomarkers Associated With the Risk of Atopic Dermatitis in Young Children. Eur J Clin Nutr. 2010;64(3):245-52. PubMed PMID: 20104235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant nutrient intakes and corresponding biomarkers associated with the risk of atopic dermatitis in young children. AU - Oh,S-Y, AU - Chung,J, AU - Kim,M-K, AU - Kwon,S O, AU - Cho,B-H, Y1 - 2010/01/27/ PY - 2010/1/28/entrez PY - 2010/1/28/pubmed PY - 2010/5/15/medline SP - 245 EP - 52 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 64 IS - 3 N2 - BACKGROUND/OBJECTIVES: To investigate the association of antioxidant nutritional status with the risk of atopic dermatitis (AD) in young children in a case-control, population-based study. SUBJECTS/METHODS: Identified from preschools by using the Korean version of the International Study of Asthma and Allergies in Childhood (ISAAC). Final analysis included 180 AD (mean age 5.3+/-0.9 years) and 242 non-AD (mean age 5.2+/-1.0 years) children. Diet was assessed using a validated semi-quantitative food frequency questionnaire. Fasting blood samples were used for analyses of fat-soluble vitamins (retinol, alpha-tocopherol, and beta-carotene) and vitamin C. RESULTS: AD was associated negatively with intakes of antioxidant-related nutrients. The adjusted odds ratio (OR) and 95% confidence interval (95% CI) were 0.44 (0.22-0.88) for the highest (vs lowest) quintile of beta-carotene. A similar association was observed for dietary vitamin E (OR=0.33, 95% CI=0.16-0.67), folic acid (OR=0.37, 95% CI=0.18-0.73), and iron (OR=0.39, 95% CI=0.19-0.79). Reduced AD risk was found with 1 s.d. increase of serum alpha-tocopherol [OR=0.64, 95% CI=0.41-0.98) and retinol (OR=0.74, 95% CI=0.58-0.96) concentrations, and marginally with that of serum beta-carotene levels (P=0.0749 for trend). There was no relationship of AD risk with dietary and plasma vitamin C as well as nutrient supplement intake regardless of nutrient type. AD was predicted better by the intake measure than the corresponding blood biomarker regarding vitamin E and beta-carotene. CONCLUSIONS: These findings suggest that higher antioxidant nutritional status reduces the risk of AD and that such risk-reduction effects depend on nutrient type. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/20104235/Antioxidant_nutrient_intakes_and_corresponding_biomarkers_associated_with_the_risk_of_atopic_dermatitis_in_young_children_ L2 - http://dx.doi.org/10.1038/ejcn.2009.148 DB - PRIME DP - Unbound Medicine ER -