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[Protective effect of N-acetylcysteine on liver and lung in mice after ischemia-reperfusion injury].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 Nov; 25(11):1058-60.XB

Abstract

AIM

To investigate protective effect of N-acetylcysteine (NAC) on liver and lung in mice after hepatic ischemia/reperfusion injury.

METHODS

BALB/s mice were used in a model of partial hepatic ischemia/reperfusion (I/R) injury. They are divided randomly to sham-operated control group (SH), hepatic I/R group or NAC pretreated in hepatic I/R group (I/R-NAC). The level of TNF-alpha in portal vein and plasma ALT were measured at 1 hour and 3 hour, respectively after reperfusion. Lung tissue wet-to-dry (W/D) weight ratio compared.

RESULTS

Lung tissue W/D ratio showed significant difference between two groups; The expressions of TLR2/4 mRNA in liver and lung increased obviously after hepatic I/R injury. Histological evaluation showed several changes in lung tissue in I/R group. The level of TNF-alpha and ALT declined significantly in the group pretreated by NAC.

CONCLUSION

N-acetylcysteine can inhibit the activation of TLR2/4 and reduce TNF-alpha secretion resulted from I/R injury it might abate liver and lung injury following partial hepatic ischemia-reperfusion in mice.

Authors+Show Affiliations

Zeng S
Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China.
Lin Y
No affiliation info available
Di JF
No affiliation info available
Feng Z
No affiliation info available

MeSH

AcetylcysteineAlanine TransaminaseAnimalsGene Expression RegulationLiverLungMaleMiceMice, Inbred BALB COrgan SizeRNA, MessengerReperfusion InjuryTime FactorsToll-Like Receptor 2Toll-Like Receptor 4Tumor Necrosis Factor-alpha

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

20104683

Citation

Zeng, Shan, et al. "[Protective Effect of N-acetylcysteine On Liver and Lung in Mice After Ischemia-reperfusion Injury]." Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi = Chinese Journal of Cellular and Molecular Immunology, vol. 25, no. 11, 2009, pp. 1058-60.
Zeng S, Lin Y, Di JF, et al. [Protective effect of N-acetylcysteine on liver and lung in mice after ischemia-reperfusion injury]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009;25(11):1058-60.
Zeng, S., Lin, Y., Di, J. F., & Feng, Z. (2009). [Protective effect of N-acetylcysteine on liver and lung in mice after ischemia-reperfusion injury]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi = Chinese Journal of Cellular and Molecular Immunology, 25(11), 1058-60.
Zeng S, et al. [Protective Effect of N-acetylcysteine On Liver and Lung in Mice After Ischemia-reperfusion Injury]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009;25(11):1058-60. PubMed PMID: 20104683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Protective effect of N-acetylcysteine on liver and lung in mice after ischemia-reperfusion injury]. AU - Zeng,Shan, AU - Lin,Yi, AU - Di,Jing-fang, AU - Feng,Zheng, PY - 2010/1/29/entrez PY - 2010/1/29/pubmed PY - 2010/3/11/medline SP - 1058 EP - 60 JF - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology JO - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi VL - 25 IS - 11 N2 - AIM: To investigate protective effect of N-acetylcysteine (NAC) on liver and lung in mice after hepatic ischemia/reperfusion injury. METHODS: BALB/s mice were used in a model of partial hepatic ischemia/reperfusion (I/R) injury. They are divided randomly to sham-operated control group (SH), hepatic I/R group or NAC pretreated in hepatic I/R group (I/R-NAC). The level of TNF-alpha in portal vein and plasma ALT were measured at 1 hour and 3 hour, respectively after reperfusion. Lung tissue wet-to-dry (W/D) weight ratio compared. RESULTS: Lung tissue W/D ratio showed significant difference between two groups; The expressions of TLR2/4 mRNA in liver and lung increased obviously after hepatic I/R injury. Histological evaluation showed several changes in lung tissue in I/R group. The level of TNF-alpha and ALT declined significantly in the group pretreated by NAC. CONCLUSION: N-acetylcysteine can inhibit the activation of TLR2/4 and reduce TNF-alpha secretion resulted from I/R injury it might abate liver and lung injury following partial hepatic ischemia-reperfusion in mice. SN - 1007-8738 UR - https://www.unboundmedicine.com/medline/citation/20104683/[Protective_effect_of_N_acetylcysteine_on_liver_and_lung_in_mice_after_ischemia_reperfusion_injury]_ DB - PRIME DP - Unbound Medicine ER -