Tags

Type your tag names separated by a space and hit enter

[Protective effect of N-acetylcysteine on liver and lung in mice after ischemia-reperfusion injury].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 Nov; 25(11):1058-60.XB

Abstract

AIM

To investigate protective effect of N-acetylcysteine (NAC) on liver and lung in mice after hepatic ischemia/reperfusion injury.

METHODS

BALB/s mice were used in a model of partial hepatic ischemia/reperfusion (I/R) injury. They are divided randomly to sham-operated control group (SH), hepatic I/R group or NAC pretreated in hepatic I/R group (I/R-NAC). The level of TNF-alpha in portal vein and plasma ALT were measured at 1 hour and 3 hour, respectively after reperfusion. Lung tissue wet-to-dry (W/D) weight ratio compared.

RESULTS

Lung tissue W/D ratio showed significant difference between two groups; The expressions of TLR2/4 mRNA in liver and lung increased obviously after hepatic I/R injury. Histological evaluation showed several changes in lung tissue in I/R group. The level of TNF-alpha and ALT declined significantly in the group pretreated by NAC.

CONCLUSION

N-acetylcysteine can inhibit the activation of TLR2/4 and reduce TNF-alpha secretion resulted from I/R injury it might abate liver and lung injury following partial hepatic ischemia-reperfusion in mice.

Authors+Show Affiliations

Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

20104683

Citation

Zeng, Shan, et al. "[Protective Effect of N-acetylcysteine On Liver and Lung in Mice After Ischemia-reperfusion Injury]." Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi = Chinese Journal of Cellular and Molecular Immunology, vol. 25, no. 11, 2009, pp. 1058-60.
Zeng S, Lin Y, Di JF, et al. [Protective effect of N-acetylcysteine on liver and lung in mice after ischemia-reperfusion injury]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009;25(11):1058-60.
Zeng, S., Lin, Y., Di, J. F., & Feng, Z. (2009). [Protective effect of N-acetylcysteine on liver and lung in mice after ischemia-reperfusion injury]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi = Chinese Journal of Cellular and Molecular Immunology, 25(11), 1058-60.
Zeng S, et al. [Protective Effect of N-acetylcysteine On Liver and Lung in Mice After Ischemia-reperfusion Injury]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009;25(11):1058-60. PubMed PMID: 20104683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Protective effect of N-acetylcysteine on liver and lung in mice after ischemia-reperfusion injury]. AU - Zeng,Shan, AU - Lin,Yi, AU - Di,Jing-fang, AU - Feng,Zheng, PY - 2010/1/29/entrez PY - 2010/1/29/pubmed PY - 2010/3/11/medline SP - 1058 EP - 60 JF - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology JO - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi VL - 25 IS - 11 N2 - AIM: To investigate protective effect of N-acetylcysteine (NAC) on liver and lung in mice after hepatic ischemia/reperfusion injury. METHODS: BALB/s mice were used in a model of partial hepatic ischemia/reperfusion (I/R) injury. They are divided randomly to sham-operated control group (SH), hepatic I/R group or NAC pretreated in hepatic I/R group (I/R-NAC). The level of TNF-alpha in portal vein and plasma ALT were measured at 1 hour and 3 hour, respectively after reperfusion. Lung tissue wet-to-dry (W/D) weight ratio compared. RESULTS: Lung tissue W/D ratio showed significant difference between two groups; The expressions of TLR2/4 mRNA in liver and lung increased obviously after hepatic I/R injury. Histological evaluation showed several changes in lung tissue in I/R group. The level of TNF-alpha and ALT declined significantly in the group pretreated by NAC. CONCLUSION: N-acetylcysteine can inhibit the activation of TLR2/4 and reduce TNF-alpha secretion resulted from I/R injury it might abate liver and lung injury following partial hepatic ischemia-reperfusion in mice. SN - 1007-8738 UR - https://www.unboundmedicine.com/medline/citation/20104683/[Protective_effect_of_N_acetylcysteine_on_liver_and_lung_in_mice_after_ischemia_reperfusion_injury]_ DB - PRIME DP - Unbound Medicine ER -