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Three-year survival after first-ever ischemic stroke is predicted by initial stroke severity: A hospital-based study.
Clin Neurol Neurosurg. 2010 May; 112(4):296-301.CN

Abstract

OBJECTIVE

We aimed to report 3-year survival and causes of death of first-ever ischemic stroke stratified by initial stroke severity.

STUDY DESIGN AND SETTING

From September 1998 to October 1999, 360 acute first-ever ischemic stroke patients consecutively admitted were followed up prospectively. Patients' vital status and causes of death were identified from the National Death Registry, till December 31, 2002. Potential prognostic factors available at admission were evaluated using Cox proportional hazards regression analysis with bootstrap validation.

RESULTS

Three hundred and sixty patients, 58% males with age 64.9 years on average, were followed up for 43.4 months with no lost follow-up. Ninety-two (25.6%) patients died, 25 in the first month. The cumulative case-fatality rates were 12.2%, 15.8%, 20.5% and 25.6% for years 1-4. The proportion of vascular deaths was 84% during the first 30 days and 71% for the subsequent 5 months. The hazard ratio (95% CI) was 1.08 (1.05-1.11) for age (1-year increment), 335.90 (20.72-5446.23) for NIHSS 16-38, 2.48 (1.39-4.42) for NIHSS 7-15, and 0.95 (0.91-0.99) for an interaction term of age and NIHSS 16-38.

CONCLUSION

This study confirmed that the initial stroke severity and age were early prognostic factors for 3-year survival after first-ever ischemic stroke, and further demonstrated that the influence of age on survival time was slightly lower in patients with severe stroke.

Authors+Show Affiliations

Division of Cerebrovascular Diseases, Department of Neurology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20106589

Citation

Chang, Ku-Chou, et al. "Three-year Survival After First-ever Ischemic Stroke Is Predicted By Initial Stroke Severity: a Hospital-based Study." Clinical Neurology and Neurosurgery, vol. 112, no. 4, 2010, pp. 296-301.
Chang KC, Lee HC, Tseng MC, et al. Three-year survival after first-ever ischemic stroke is predicted by initial stroke severity: A hospital-based study. Clin Neurol Neurosurg. 2010;112(4):296-301.
Chang, K. C., Lee, H. C., Tseng, M. C., & Huang, Y. C. (2010). Three-year survival after first-ever ischemic stroke is predicted by initial stroke severity: A hospital-based study. Clinical Neurology and Neurosurgery, 112(4), 296-301. https://doi.org/10.1016/j.clineuro.2009.12.016
Chang KC, et al. Three-year Survival After First-ever Ischemic Stroke Is Predicted By Initial Stroke Severity: a Hospital-based Study. Clin Neurol Neurosurg. 2010;112(4):296-301. PubMed PMID: 20106589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three-year survival after first-ever ischemic stroke is predicted by initial stroke severity: A hospital-based study. AU - Chang,Ku-Chou, AU - Lee,Hsuei-Chen, AU - Tseng,Mei-Chiun, AU - Huang,Yu-Ching, Y1 - 2010/01/27/ PY - 2009/04/20/received PY - 2009/12/02/revised PY - 2009/12/23/accepted PY - 2010/1/29/entrez PY - 2010/1/29/pubmed PY - 2010/6/18/medline SP - 296 EP - 301 JF - Clinical neurology and neurosurgery JO - Clin Neurol Neurosurg VL - 112 IS - 4 N2 - OBJECTIVE: We aimed to report 3-year survival and causes of death of first-ever ischemic stroke stratified by initial stroke severity. STUDY DESIGN AND SETTING: From September 1998 to October 1999, 360 acute first-ever ischemic stroke patients consecutively admitted were followed up prospectively. Patients' vital status and causes of death were identified from the National Death Registry, till December 31, 2002. Potential prognostic factors available at admission were evaluated using Cox proportional hazards regression analysis with bootstrap validation. RESULTS: Three hundred and sixty patients, 58% males with age 64.9 years on average, were followed up for 43.4 months with no lost follow-up. Ninety-two (25.6%) patients died, 25 in the first month. The cumulative case-fatality rates were 12.2%, 15.8%, 20.5% and 25.6% for years 1-4. The proportion of vascular deaths was 84% during the first 30 days and 71% for the subsequent 5 months. The hazard ratio (95% CI) was 1.08 (1.05-1.11) for age (1-year increment), 335.90 (20.72-5446.23) for NIHSS 16-38, 2.48 (1.39-4.42) for NIHSS 7-15, and 0.95 (0.91-0.99) for an interaction term of age and NIHSS 16-38. CONCLUSION: This study confirmed that the initial stroke severity and age were early prognostic factors for 3-year survival after first-ever ischemic stroke, and further demonstrated that the influence of age on survival time was slightly lower in patients with severe stroke. SN - 1872-6968 UR - https://www.unboundmedicine.com/medline/citation/20106589/Three_year_survival_after_first_ever_ischemic_stroke_is_predicted_by_initial_stroke_severity:_A_hospital_based_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-8467(10)00003-X DB - PRIME DP - Unbound Medicine ER -