Tags

Type your tag names separated by a space and hit enter

Guidance for substantiating the evidence for beneficial effects of probiotics: probiotics in chronic inflammatory bowel disease and the functional disorder irritable bowel syndrome.
J Nutr. 2010 Mar; 140(3):690S-7S.JN

Abstract

Ulcerative colitis and Crohn's disease, the 2 distinct idiopathic pathologies of inflammatory bowel diseases, are spontaneously relapsing, immunologically mediated disorders of the gastrointestinal tract. Selected probiotics strains have been proven to be clinically effective in maintaining remission in patients with ulcerative colitis. None of the probiotics thus far tested has been shown to be effective in induction of remission or in maintenance of remission in patients with Crohn's disease. The multispecies probiotics mixture of 8 strains seems effective in the maintenance of remission in pouchitis. Irritable bowel syndrome is a functional bowel disorder manifested by chronic, recurring abdominal pain or discomfort associated with disturbed bowel habit in the absence of structural abnormalities likely to account for these symptoms. Recently conducted appropriately powered studies with different (combinations of) probiotics show positive results on reduction of symptoms, although a considerable placebo effect is also found. Mechanistic studies aimed at pathophysiological mechanisms of inflammatory bowel diseases can identify new targets for probiotic bacteria.

Authors+Show Affiliations

Chair for Biofunctionality, ZIEL-Research Center for Nutrition and Food Science, Technische Universität München, Freising-Weihenstephan, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20107148

Citation

Haller, Dirk, et al. "Guidance for Substantiating the Evidence for Beneficial Effects of Probiotics: Probiotics in Chronic Inflammatory Bowel Disease and the Functional Disorder Irritable Bowel Syndrome." The Journal of Nutrition, vol. 140, no. 3, 2010, 690S-7S.
Haller D, Antoine JM, Bengmark S, et al. Guidance for substantiating the evidence for beneficial effects of probiotics: probiotics in chronic inflammatory bowel disease and the functional disorder irritable bowel syndrome. J Nutr. 2010;140(3):690S-7S.
Haller, D., Antoine, J. M., Bengmark, S., Enck, P., Rijkers, G. T., & Lenoir-Wijnkoop, I. (2010). Guidance for substantiating the evidence for beneficial effects of probiotics: probiotics in chronic inflammatory bowel disease and the functional disorder irritable bowel syndrome. The Journal of Nutrition, 140(3), 690S-7S. https://doi.org/10.3945/jn.109.113746
Haller D, et al. Guidance for Substantiating the Evidence for Beneficial Effects of Probiotics: Probiotics in Chronic Inflammatory Bowel Disease and the Functional Disorder Irritable Bowel Syndrome. J Nutr. 2010;140(3):690S-7S. PubMed PMID: 20107148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Guidance for substantiating the evidence for beneficial effects of probiotics: probiotics in chronic inflammatory bowel disease and the functional disorder irritable bowel syndrome. AU - Haller,Dirk, AU - Antoine,Jean-Michel, AU - Bengmark,Stig, AU - Enck,Paul, AU - Rijkers,Ger T, AU - Lenoir-Wijnkoop,Irene, Y1 - 2010/01/27/ PY - 2010/1/29/entrez PY - 2010/1/29/pubmed PY - 2010/3/26/medline SP - 690S EP - 7S JF - The Journal of nutrition JO - J. Nutr. VL - 140 IS - 3 N2 - Ulcerative colitis and Crohn's disease, the 2 distinct idiopathic pathologies of inflammatory bowel diseases, are spontaneously relapsing, immunologically mediated disorders of the gastrointestinal tract. Selected probiotics strains have been proven to be clinically effective in maintaining remission in patients with ulcerative colitis. None of the probiotics thus far tested has been shown to be effective in induction of remission or in maintenance of remission in patients with Crohn's disease. The multispecies probiotics mixture of 8 strains seems effective in the maintenance of remission in pouchitis. Irritable bowel syndrome is a functional bowel disorder manifested by chronic, recurring abdominal pain or discomfort associated with disturbed bowel habit in the absence of structural abnormalities likely to account for these symptoms. Recently conducted appropriately powered studies with different (combinations of) probiotics show positive results on reduction of symptoms, although a considerable placebo effect is also found. Mechanistic studies aimed at pathophysiological mechanisms of inflammatory bowel diseases can identify new targets for probiotic bacteria. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/20107148/Guidance_for_substantiating_the_evidence_for_beneficial_effects_of_probiotics:_probiotics_in_chronic_inflammatory_bowel_disease_and_the_functional_disorder_irritable_bowel_syndrome_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.109.113746 DB - PRIME DP - Unbound Medicine ER -