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Safety and efficacy of tacrolimus ointment versus pimecrolimus cream in the treatment of patients with atopic dermatitis previously treated with corticosteroids.
Acta Derm Venereol. 2010; 90(1):58-64.AD

Abstract

Adult and pediatric patients (n = 347) with atopic dermatitis enrolled in three multicenter, randomized, 6-week studies who had previously used steroids were analyzed to examine the null hypothesis that improvement in atopic dermatitis initiated after prior treatment with steroids eliminates any subsequent treatment differences between tacrolimus ointment and pimecrolimus cream. Of these patients, 171 were randomized to tacrolimus ointment and 176 to pimecrolimus cream. Based on improvement in the Eczema Area and Severity Index at the end of study, tacrolimus ointment was significantly more effective than pimecrolimus cream (p = 0.0002). Tacrolimus ointment was also significantly more effective than pimecrolimus cream at the end of study in all secondary end-points. Overall, the frequency of adverse events was comparable between treatment groups (24.0% for tacrolimus ointment vs. 25.6% for pimecrolimus cream). Tacrolimus ointment is more effective, with a similar safety profile, compared with pimecrolimus cream in patients with atopic dermatitis previously treated with topical corticosteroids.

Authors+Show Affiliations

Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Ave., RMSB, Room 2023-A, Miami, Florida, 33136, USA. rkirsner@med.miami.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20107727

Citation

Kirsner, Robert S., et al. "Safety and Efficacy of Tacrolimus Ointment Versus Pimecrolimus Cream in the Treatment of Patients With Atopic Dermatitis Previously Treated With Corticosteroids." Acta Dermato-venereologica, vol. 90, no. 1, 2010, pp. 58-64.
Kirsner RS, Heffernan MP, Antaya R. Safety and efficacy of tacrolimus ointment versus pimecrolimus cream in the treatment of patients with atopic dermatitis previously treated with corticosteroids. Acta Derm Venereol. 2010;90(1):58-64.
Kirsner, R. S., Heffernan, M. P., & Antaya, R. (2010). Safety and efficacy of tacrolimus ointment versus pimecrolimus cream in the treatment of patients with atopic dermatitis previously treated with corticosteroids. Acta Dermato-venereologica, 90(1), 58-64. https://doi.org/10.2340/00015555-0748
Kirsner RS, Heffernan MP, Antaya R. Safety and Efficacy of Tacrolimus Ointment Versus Pimecrolimus Cream in the Treatment of Patients With Atopic Dermatitis Previously Treated With Corticosteroids. Acta Derm Venereol. 2010;90(1):58-64. PubMed PMID: 20107727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Safety and efficacy of tacrolimus ointment versus pimecrolimus cream in the treatment of patients with atopic dermatitis previously treated with corticosteroids. AU - Kirsner,Robert S, AU - Heffernan,Michael P, AU - Antaya,Richard, PY - 2010/1/29/entrez PY - 2010/1/29/pubmed PY - 2010/4/9/medline SP - 58 EP - 64 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 90 IS - 1 N2 - Adult and pediatric patients (n = 347) with atopic dermatitis enrolled in three multicenter, randomized, 6-week studies who had previously used steroids were analyzed to examine the null hypothesis that improvement in atopic dermatitis initiated after prior treatment with steroids eliminates any subsequent treatment differences between tacrolimus ointment and pimecrolimus cream. Of these patients, 171 were randomized to tacrolimus ointment and 176 to pimecrolimus cream. Based on improvement in the Eczema Area and Severity Index at the end of study, tacrolimus ointment was significantly more effective than pimecrolimus cream (p = 0.0002). Tacrolimus ointment was also significantly more effective than pimecrolimus cream at the end of study in all secondary end-points. Overall, the frequency of adverse events was comparable between treatment groups (24.0% for tacrolimus ointment vs. 25.6% for pimecrolimus cream). Tacrolimus ointment is more effective, with a similar safety profile, compared with pimecrolimus cream in patients with atopic dermatitis previously treated with topical corticosteroids. SN - 1651-2057 UR - https://www.unboundmedicine.com/medline/citation/20107727/Safety_and_efficacy_of_tacrolimus_ointment_versus_pimecrolimus_cream_in_the_treatment_of_patients_with_atopic_dermatitis_previously_treated_with_corticosteroids_ DB - PRIME DP - Unbound Medicine ER -