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Recent data on cannabinoids and their pharmacological implications in neuropathic pain.

Abstract

Natural cannabinoids have been used for centuries for their psychotropic properties, but their possible therapeutic implications in analgesia have been recently documented. The present review intended to make an analysis of the neuroanatomy and physiology of the cannabinoid system (receptors, functions, agents acting on these receptors) and of its implications in neuropathic pain. There were also described the complex phenomena implicated in the generation and maintenance of neuropathic pain, by high lightening the implications of endogenous cannabinoids in this complex of painful conditions. The pharmacological analgesia test proves of cannabinoid implication in neuropathic pain was sustained by many studies presented in this paper. Therapeutic approaches using natural and synthetic cannabinoid receptor agonists were reviewed. Therapeutic perspectives in neuropathic pain might involve the development of new agents that influence the cannabinoid system. Thus, peripheral acting cannabinoid 1 receptors agonists, selective cannabinoid 2 receptor agonists and also modulators of endocannabinoids metabolism might be a way to success in the treatment of this complex entity called neuropathic pain.

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  • Authors+Show Affiliations

    ,

    "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. andreiacoman@yahoo.com

    , , ,

    Source

    MeSH

    Animals
    Cannabinoid Receptor Modulators
    Cannabinoids
    Humans
    Neuralgia
    Pain
    Pain Measurement
    Receptor, Cannabinoid, CB1
    Receptor, Cannabinoid, CB2

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    20108515

    Citation

    Coman, Oana Andreia, et al. "Recent Data On Cannabinoids and Their Pharmacological Implications in Neuropathic Pain." Journal of Medicine and Life, vol. 1, no. 4, 2008, pp. 365-75.
    Coman OA, Paunescu H, Coman L, et al. Recent data on cannabinoids and their pharmacological implications in neuropathic pain. J Med Life. 2008;1(4):365-75.
    Coman, O. A., Paunescu, H., Coman, L., Badarau, A., & Fulga, I. (2008). Recent data on cannabinoids and their pharmacological implications in neuropathic pain. Journal of Medicine and Life, 1(4), pp. 365-75.
    Coman OA, et al. Recent Data On Cannabinoids and Their Pharmacological Implications in Neuropathic Pain. J Med Life. 2008;1(4):365-75. PubMed PMID: 20108515.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Recent data on cannabinoids and their pharmacological implications in neuropathic pain. AU - Coman,Oana Andreia, AU - Paunescu,Horia, AU - Coman,Laurentiu, AU - Badarau,Anca, AU - Fulga,Ion, PY - 2010/1/30/entrez PY - 2008/10/1/pubmed PY - 2010/2/27/medline SP - 365 EP - 75 JF - Journal of medicine and life JO - J Med Life VL - 1 IS - 4 N2 - Natural cannabinoids have been used for centuries for their psychotropic properties, but their possible therapeutic implications in analgesia have been recently documented. The present review intended to make an analysis of the neuroanatomy and physiology of the cannabinoid system (receptors, functions, agents acting on these receptors) and of its implications in neuropathic pain. There were also described the complex phenomena implicated in the generation and maintenance of neuropathic pain, by high lightening the implications of endogenous cannabinoids in this complex of painful conditions. The pharmacological analgesia test proves of cannabinoid implication in neuropathic pain was sustained by many studies presented in this paper. Therapeutic approaches using natural and synthetic cannabinoid receptor agonists were reviewed. Therapeutic perspectives in neuropathic pain might involve the development of new agents that influence the cannabinoid system. Thus, peripheral acting cannabinoid 1 receptors agonists, selective cannabinoid 2 receptor agonists and also modulators of endocannabinoids metabolism might be a way to success in the treatment of this complex entity called neuropathic pain. SN - 1844-122X UR - https://www.unboundmedicine.com/medline/citation/20108515/Recent_data_on_cannabinoids_and_their_pharmacological_implications_in_neuropathic_pain_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20108515/ DB - PRIME DP - Unbound Medicine ER -