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Inhibition of dorsal hippocampal nitric oxide synthesis potentiates ethanol-induced state-dependent memory in mice.
Behav Brain Res. 2010 Jun 19; 209(2):189-95.BB

Abstract

In an effort to understand the involvement of dorsal hippocampal nitric oxide system in ethanol (ETOH)-induced state-dependent memory, the effects of microinjection of l-arginine (a precursor of nitric oxide) and/or l-NAME (a nitric oxide synthase inhibitor) into the CA1 regions of dorsal hippocampus on this kind of memory were examined. In order to assess memory retrieval, a single trial step-down inhibitory avoidance task was used in mice. Pre-training intraperitoneal administration of ETOH (0.5 and 1g/kg) dose dependently caused amnesia, while pre-test administration of the same doses of ETOH restored the retrieval and induced state-dependent memory. Pre-test microinjection of l-arginine (0.5, 0.75 and 1 microg/mouse), into the CA1 region of dorsal hippocampus (intra-CA1) had no effect on memory retrieval. However, pre-test intra-CA1 microinjection of the same doses of l-arginine interestingly inhibited ETOH-induced state-dependent memory. The maximum response was obtained with 1 microg/mouse of l-arginine. Furthermore, memory impairment was produced following pre-test intra-CA1 microinjection of l-NAME (0.5, 0.75 and 1 microg/mouse). Pre-test co-administration of a higher dose of l-NAME (1 microg/mouse, intra-CA1) with an ineffective dose of ETOH (0.25 g/kg), improved the memory retrieval. Pre-test intra-CA1 microinjection of l-arginine or l-NAME could not affect ETOH-induced amnesia. In addition, l-arginine-induced inhibition of the pre-test ETOH response was decreased by pre-test microinjection of l-NAME. The ensemble of these observations suggests that ETOH-induced state-dependent memory can be modulated through the dorsal hippocampal nitric oxide system.

Authors+Show Affiliations

Department of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran. rezayof@khayam.ut.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20109498

Citation

Rezayof, Ameneh, et al. "Inhibition of Dorsal Hippocampal Nitric Oxide Synthesis Potentiates Ethanol-induced State-dependent Memory in Mice." Behavioural Brain Research, vol. 209, no. 2, 2010, pp. 189-95.
Rezayof A, Zare-Chahoki A, Zarrindast MR, et al. Inhibition of dorsal hippocampal nitric oxide synthesis potentiates ethanol-induced state-dependent memory in mice. Behav Brain Res. 2010;209(2):189-95.
Rezayof, A., Zare-Chahoki, A., Zarrindast, M. R., & Rassouli, Y. (2010). Inhibition of dorsal hippocampal nitric oxide synthesis potentiates ethanol-induced state-dependent memory in mice. Behavioural Brain Research, 209(2), 189-95. https://doi.org/10.1016/j.bbr.2010.01.027
Rezayof A, et al. Inhibition of Dorsal Hippocampal Nitric Oxide Synthesis Potentiates Ethanol-induced State-dependent Memory in Mice. Behav Brain Res. 2010 Jun 19;209(2):189-95. PubMed PMID: 20109498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of dorsal hippocampal nitric oxide synthesis potentiates ethanol-induced state-dependent memory in mice. AU - Rezayof,Ameneh, AU - Zare-Chahoki,Ameneh, AU - Zarrindast,Mohammad-Reza, AU - Rassouli,Yassaman, Y1 - 2010/01/28/ PY - 2009/10/10/received PY - 2010/01/15/revised PY - 2010/01/20/accepted PY - 2010/1/30/entrez PY - 2010/1/30/pubmed PY - 2010/6/3/medline SP - 189 EP - 95 JF - Behavioural brain research JO - Behav Brain Res VL - 209 IS - 2 N2 - In an effort to understand the involvement of dorsal hippocampal nitric oxide system in ethanol (ETOH)-induced state-dependent memory, the effects of microinjection of l-arginine (a precursor of nitric oxide) and/or l-NAME (a nitric oxide synthase inhibitor) into the CA1 regions of dorsal hippocampus on this kind of memory were examined. In order to assess memory retrieval, a single trial step-down inhibitory avoidance task was used in mice. Pre-training intraperitoneal administration of ETOH (0.5 and 1g/kg) dose dependently caused amnesia, while pre-test administration of the same doses of ETOH restored the retrieval and induced state-dependent memory. Pre-test microinjection of l-arginine (0.5, 0.75 and 1 microg/mouse), into the CA1 region of dorsal hippocampus (intra-CA1) had no effect on memory retrieval. However, pre-test intra-CA1 microinjection of the same doses of l-arginine interestingly inhibited ETOH-induced state-dependent memory. The maximum response was obtained with 1 microg/mouse of l-arginine. Furthermore, memory impairment was produced following pre-test intra-CA1 microinjection of l-NAME (0.5, 0.75 and 1 microg/mouse). Pre-test co-administration of a higher dose of l-NAME (1 microg/mouse, intra-CA1) with an ineffective dose of ETOH (0.25 g/kg), improved the memory retrieval. Pre-test intra-CA1 microinjection of l-arginine or l-NAME could not affect ETOH-induced amnesia. In addition, l-arginine-induced inhibition of the pre-test ETOH response was decreased by pre-test microinjection of l-NAME. The ensemble of these observations suggests that ETOH-induced state-dependent memory can be modulated through the dorsal hippocampal nitric oxide system. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/20109498/Inhibition_of_dorsal_hippocampal_nitric_oxide_synthesis_potentiates_ethanol_induced_state_dependent_memory_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(10)00051-3 DB - PRIME DP - Unbound Medicine ER -