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Neurocognitive, clinical and functional correlates of subjective quality of life in Asian outpatients with schizophrenia.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Apr 16; 34(3):463-8.PN

Abstract

Quality of life (QOL) impairment is evident in patients with schizophrenia and is increasingly recognised as an important evaluation criterion of treatment outcome. Hence, this study aimed to identify the neurocognitive, clinical and functional parameters associated with subjective QOL in patients with schizophrenia within an Asian context, and specifically in an outpatient setting. This study was conducted on 83 outpatients with DSM-IV diagnosis of schizophrenia, and 47 age- and gender-matched healthy controls. All participants were administered with the World Health Organisation Quality of Life Assessment-Brief Form (WHOQOL-BREF) and Brief Assessment of Cognition in Schizophrenia (BACS), to measure quality of life and cognitive function respectively. Patients were also assessed for severity of psychopathology, as well as level of psychosocial functioning, using the Positive and Negative Syndrome Scale (PANSS) and Global Assessment of Functioning (GAF) rating scales respectively. Specific psychopathology (greater severity of PANSS negative symptoms, general psychopathology subscale scores), cognitive deficits (working and verbal memories), and lower GAF scores were correlated with poorer QOL in patients. Multivariate analyses revealed that younger age, being single and lower level of psychosocial functioning were associated with poorer QOL but level of psychosocial functioning did not appear to mediate the effects of symptoms and neurocognitive deficits on QOL. Overall, this study highlighted the need for clinicians to pay more attention to these clinical, neurocognitive and functional parameters and their integrative relationships with QOL in order to optimise the treatment outcomes of patients with schizophrenia.

Authors+Show Affiliations

Research Division, Institute of Mental Health/Woodbridge Hospital, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20109511

Citation

Woon, Puay San, et al. "Neurocognitive, Clinical and Functional Correlates of Subjective Quality of Life in Asian Outpatients With Schizophrenia." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 34, no. 3, 2010, pp. 463-8.
Woon PS, Chia MY, Chan WY, et al. Neurocognitive, clinical and functional correlates of subjective quality of life in Asian outpatients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(3):463-8.
Woon, P. S., Chia, M. Y., Chan, W. Y., & Sim, K. (2010). Neurocognitive, clinical and functional correlates of subjective quality of life in Asian outpatients with schizophrenia. Progress in Neuro-psychopharmacology & Biological Psychiatry, 34(3), 463-8. https://doi.org/10.1016/j.pnpbp.2010.01.014
Woon PS, et al. Neurocognitive, Clinical and Functional Correlates of Subjective Quality of Life in Asian Outpatients With Schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Apr 16;34(3):463-8. PubMed PMID: 20109511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurocognitive, clinical and functional correlates of subjective quality of life in Asian outpatients with schizophrenia. AU - Woon,Puay San, AU - Chia,Ming Ying, AU - Chan,Wai Yen, AU - Sim,Kang, Y1 - 2010/01/25/ PY - 2009/09/23/received PY - 2010/01/20/revised PY - 2010/01/20/accepted PY - 2010/1/30/entrez PY - 2010/1/30/pubmed PY - 2010/6/25/medline SP - 463 EP - 8 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 34 IS - 3 N2 - Quality of life (QOL) impairment is evident in patients with schizophrenia and is increasingly recognised as an important evaluation criterion of treatment outcome. Hence, this study aimed to identify the neurocognitive, clinical and functional parameters associated with subjective QOL in patients with schizophrenia within an Asian context, and specifically in an outpatient setting. This study was conducted on 83 outpatients with DSM-IV diagnosis of schizophrenia, and 47 age- and gender-matched healthy controls. All participants were administered with the World Health Organisation Quality of Life Assessment-Brief Form (WHOQOL-BREF) and Brief Assessment of Cognition in Schizophrenia (BACS), to measure quality of life and cognitive function respectively. Patients were also assessed for severity of psychopathology, as well as level of psychosocial functioning, using the Positive and Negative Syndrome Scale (PANSS) and Global Assessment of Functioning (GAF) rating scales respectively. Specific psychopathology (greater severity of PANSS negative symptoms, general psychopathology subscale scores), cognitive deficits (working and verbal memories), and lower GAF scores were correlated with poorer QOL in patients. Multivariate analyses revealed that younger age, being single and lower level of psychosocial functioning were associated with poorer QOL but level of psychosocial functioning did not appear to mediate the effects of symptoms and neurocognitive deficits on QOL. Overall, this study highlighted the need for clinicians to pay more attention to these clinical, neurocognitive and functional parameters and their integrative relationships with QOL in order to optimise the treatment outcomes of patients with schizophrenia. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/20109511/Neurocognitive_clinical_and_functional_correlates_of_subjective_quality_of_life_in_Asian_outpatients_with_schizophrenia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(10)00022-9 DB - PRIME DP - Unbound Medicine ER -