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Recent insights into atopic dermatitis and implications for management of infectious complications.
J Allergy Clin Immunol 2010; 125(1):4-13; quiz 14-5JA

Abstract

Atopic dermatitis (AD) is a common complex disease that frequently follows a chronic relapsing course and affects the quality of life of patients and families in a significant manner. New insights into the pathophysiology of AD point to an important role of structural abnormalities in the epidermis combined with immune dysregulation. Patients with AD have a unique predisposition to colonization or infection by a number of microbial organisms, most notably Staphylococcus aureus and herpes simplex virus. A multipronged approach directed at healing or protecting the skin barrier and addressing the immune dysregulation is necessary to improve the likelihood of successful outcomes.

Authors+Show Affiliations

Division of Pediatric Allergy-Immunology, Department of Pediatrics, National Jewish Health and University of Colorado School of Medicine, 1400 Jackson St, Rm J310, Denver, CO 80206, USA. boguniewiczm@njhealth.orgNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

20109729

Citation

Boguniewicz, Mark, and Donald Y M. Leung. "Recent Insights Into Atopic Dermatitis and Implications for Management of Infectious Complications." The Journal of Allergy and Clinical Immunology, vol. 125, no. 1, 2010, pp. 4-13; quiz 14-5.
Boguniewicz M, Leung DY. Recent insights into atopic dermatitis and implications for management of infectious complications. J Allergy Clin Immunol. 2010;125(1):4-13; quiz 14-5.
Boguniewicz, M., & Leung, D. Y. (2010). Recent insights into atopic dermatitis and implications for management of infectious complications. The Journal of Allergy and Clinical Immunology, 125(1), pp. 4-13; quiz 14-5. doi:10.1016/j.jaci.2009.11.027.
Boguniewicz M, Leung DY. Recent Insights Into Atopic Dermatitis and Implications for Management of Infectious Complications. J Allergy Clin Immunol. 2010;125(1):4-13; quiz 14-5. PubMed PMID: 20109729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recent insights into atopic dermatitis and implications for management of infectious complications. AU - Boguniewicz,Mark, AU - Leung,Donald Y M, PY - 2009/10/26/received PY - 2009/11/19/revised PY - 2009/11/19/accepted PY - 2010/1/30/entrez PY - 2010/1/30/pubmed PY - 2010/2/26/medline SP - 4-13; quiz 14-5 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 125 IS - 1 N2 - Atopic dermatitis (AD) is a common complex disease that frequently follows a chronic relapsing course and affects the quality of life of patients and families in a significant manner. New insights into the pathophysiology of AD point to an important role of structural abnormalities in the epidermis combined with immune dysregulation. Patients with AD have a unique predisposition to colonization or infection by a number of microbial organisms, most notably Staphylococcus aureus and herpes simplex virus. A multipronged approach directed at healing or protecting the skin barrier and addressing the immune dysregulation is necessary to improve the likelihood of successful outcomes. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/20109729/Recent_insights_into_atopic_dermatitis_and_implications_for_management_of_infectious_complications_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(09)01748-5 DB - PRIME DP - Unbound Medicine ER -