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Predictive value of symptoms for early detection of ovarian cancer.
J Natl Cancer Inst 2010; 102(4):222-9JNCI

Abstract

BACKGROUND

A recent consensus statement encouraged use of certain symptoms to diagnose ovarian cancer earlier. We assessed the sensitivity, specificity, and positive predictive value of a proposed symptom index and of symptoms included in the consensus recommendation.

METHODS

In-person interviews were conducted with 812 case patients, aged 35-74 years, who had epithelial ovarian cancer that was diagnosed from January 1, 2002, through December 31, 2005, and with 1313 population-based control subjects. The symptom index was considered positive when pelvic or abdominal pain or bloating or feeling full was reported at least daily for at least 1 week, with an onset of less than 12 months before diagnosis or a reference date (for control subjects). The consensus criteria were considered fulfilled when any symptom above or urinary urgency or frequency was reported for at least 1 month, with an onset of less than 12 months before diagnosis or a reference date. Positive predictive value was calculated by use of external estimates of cancer prevalence.

RESULTS

Most case patients who had a positive index or met consensus criteria did so only within 5 months before diagnosis. Symptoms (except nausea) were somewhat less likely to have occurred among women diagnosed with early-stage than late-stage ovarian cancer. The estimated positive predictive value of the symptom index or symptoms meeting the consensus criteria was 0.6%-1.1% overall and less than 0.5% for early-stage disease.

CONCLUSION

Use of symptoms to trigger medical evaluation for ovarian cancer is likely to result in diagnosis of the disease in only one of 100 women in the general population with such symptoms.

Authors+Show Affiliations

Program in Epidemiology, Fred Hutchinson Cancer Research Center, PO Box 19024, Seattle, WA 98108-1024, USA. mrossing@fhcrc.orgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20110551

Citation

Rossing, Mary Anne, et al. "Predictive Value of Symptoms for Early Detection of Ovarian Cancer." Journal of the National Cancer Institute, vol. 102, no. 4, 2010, pp. 222-9.
Rossing MA, Wicklund KG, Cushing-Haugen KL, et al. Predictive value of symptoms for early detection of ovarian cancer. J Natl Cancer Inst. 2010;102(4):222-9.
Rossing, M. A., Wicklund, K. G., Cushing-Haugen, K. L., & Weiss, N. S. (2010). Predictive value of symptoms for early detection of ovarian cancer. Journal of the National Cancer Institute, 102(4), pp. 222-9. doi:10.1093/jnci/djp500.
Rossing MA, et al. Predictive Value of Symptoms for Early Detection of Ovarian Cancer. J Natl Cancer Inst. 2010 Feb 24;102(4):222-9. PubMed PMID: 20110551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictive value of symptoms for early detection of ovarian cancer. AU - Rossing,Mary Anne, AU - Wicklund,Kristine G, AU - Cushing-Haugen,Kara L, AU - Weiss,Noel S, Y1 - 2010/01/28/ PY - 2010/1/30/entrez PY - 2010/1/30/pubmed PY - 2010/3/17/medline SP - 222 EP - 9 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 102 IS - 4 N2 - BACKGROUND: A recent consensus statement encouraged use of certain symptoms to diagnose ovarian cancer earlier. We assessed the sensitivity, specificity, and positive predictive value of a proposed symptom index and of symptoms included in the consensus recommendation. METHODS: In-person interviews were conducted with 812 case patients, aged 35-74 years, who had epithelial ovarian cancer that was diagnosed from January 1, 2002, through December 31, 2005, and with 1313 population-based control subjects. The symptom index was considered positive when pelvic or abdominal pain or bloating or feeling full was reported at least daily for at least 1 week, with an onset of less than 12 months before diagnosis or a reference date (for control subjects). The consensus criteria were considered fulfilled when any symptom above or urinary urgency or frequency was reported for at least 1 month, with an onset of less than 12 months before diagnosis or a reference date. Positive predictive value was calculated by use of external estimates of cancer prevalence. RESULTS: Most case patients who had a positive index or met consensus criteria did so only within 5 months before diagnosis. Symptoms (except nausea) were somewhat less likely to have occurred among women diagnosed with early-stage than late-stage ovarian cancer. The estimated positive predictive value of the symptom index or symptoms meeting the consensus criteria was 0.6%-1.1% overall and less than 0.5% for early-stage disease. CONCLUSION: Use of symptoms to trigger medical evaluation for ovarian cancer is likely to result in diagnosis of the disease in only one of 100 women in the general population with such symptoms. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/20110551/Predictive_value_of_symptoms_for_early_detection_of_ovarian_cancer_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djp500 DB - PRIME DP - Unbound Medicine ER -