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Parvovirus b19 DNA is commonly harboured in human skin.
Dermatology. 2010; 220(2):138-42.D

Abstract

BACKGROUND

Parvovirus B19 is the aetiological agent of erythema infectiosum. The presence of B19 DNA in lesional skin of other cutaneous manifestations has frequently been reported although there is disagreement on the role of the B19 virus in tissues.

OBJECTIVES

To investigate the presence of B19 DNA (1) in skin lesions of patients with a described B19-related disease, (2) in skin lesions of B19-unrelated diseases and (3) in healthy skin.

METHODS

A total of 121 skin samples were examined for the presence of B19 DNA by PCR assays and peptide-nucleic-acid-based in situ hybridisation techniques.

RESULTS

B19 DNA was detected in 11/38 (28.9%) pityriasis lichenoides, 8/30 (26.7%) melanocytic naevi, 5/29 (17.2%) primary melanomas and 6/24 (25.0%) healthy skin biopsies. A difference in B19 DNA prevalence was observed in specimens grouped according to age, irrespective of pathologies.

CONCLUSIONS

B19 DNA can be found in skin tissues of patients with pityriasis lichenoides as well as in lesions not related to B19 infection and in healthy controls. B19 DNA can be detected in skin of young subjects in a significantly high rate compared to adults, suggesting that viral persistence may be the usual outcome after primary infection.

Authors+Show Affiliations

Division of Microbiology, University of Bologna, Bologna, Italy. francesca.bonvicini4@unibo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20110633

Citation

Bonvicini, F, et al. "Parvovirus B19 DNA Is Commonly Harboured in Human Skin." Dermatology (Basel, Switzerland), vol. 220, no. 2, 2010, pp. 138-42.
Bonvicini F, La Placa M, Manaresi E, et al. Parvovirus b19 DNA is commonly harboured in human skin. Dermatology. 2010;220(2):138-42.
Bonvicini, F., La Placa, M., Manaresi, E., Gallinella, G., Gentilomi, G. A., Zerbini, M., & Musiani, M. (2010). Parvovirus b19 DNA is commonly harboured in human skin. Dermatology (Basel, Switzerland), 220(2), 138-42. https://doi.org/10.1159/000277431
Bonvicini F, et al. Parvovirus B19 DNA Is Commonly Harboured in Human Skin. Dermatology. 2010;220(2):138-42. PubMed PMID: 20110633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parvovirus b19 DNA is commonly harboured in human skin. AU - Bonvicini,F, AU - La Placa,M, AU - Manaresi,E, AU - Gallinella,G, AU - Gentilomi,G A, AU - Zerbini,M, AU - Musiani,M, Y1 - 2010/01/26/ PY - 2009/06/08/received PY - 2009/10/24/accepted PY - 2010/1/30/entrez PY - 2010/1/30/pubmed PY - 2010/6/9/medline SP - 138 EP - 42 JF - Dermatology (Basel, Switzerland) JO - Dermatology VL - 220 IS - 2 N2 - BACKGROUND: Parvovirus B19 is the aetiological agent of erythema infectiosum. The presence of B19 DNA in lesional skin of other cutaneous manifestations has frequently been reported although there is disagreement on the role of the B19 virus in tissues. OBJECTIVES: To investigate the presence of B19 DNA (1) in skin lesions of patients with a described B19-related disease, (2) in skin lesions of B19-unrelated diseases and (3) in healthy skin. METHODS: A total of 121 skin samples were examined for the presence of B19 DNA by PCR assays and peptide-nucleic-acid-based in situ hybridisation techniques. RESULTS: B19 DNA was detected in 11/38 (28.9%) pityriasis lichenoides, 8/30 (26.7%) melanocytic naevi, 5/29 (17.2%) primary melanomas and 6/24 (25.0%) healthy skin biopsies. A difference in B19 DNA prevalence was observed in specimens grouped according to age, irrespective of pathologies. CONCLUSIONS: B19 DNA can be found in skin tissues of patients with pityriasis lichenoides as well as in lesions not related to B19 infection and in healthy controls. B19 DNA can be detected in skin of young subjects in a significantly high rate compared to adults, suggesting that viral persistence may be the usual outcome after primary infection. SN - 1421-9832 UR - https://www.unboundmedicine.com/medline/citation/20110633/Parvovirus_b19_DNA_is_commonly_harboured_in_human_skin_ L2 - https://www.karger.com?DOI=10.1159/000277431 DB - PRIME DP - Unbound Medicine ER -