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Serum leptin and adiponectin levels and risk of Barrett's esophagus and intestinal metaplasia of the gastroesophageal junction.

Abstract

Persons diagnosed with Barrett's esophagus (BE) are at increased risk of developing esophageal adenocarcinoma (EA). Obesity is a major risk factor for both BE and EA. The primary purposes of this study were to determine whether circulating levels of leptin and adiponectin, both of which are deregulated in obese states, predict risk of specialized intestinal metaplasia (SIM) occurring in the esophagus (BE) and/or gastroesophageal junction, and evaluate the extent to which they mediate the relationship between obesity and these conditions. In this case-control study, 177 persons newly diagnosed with SIM were compared with 173 general population controls using unconditional logistic regression. Females in the highest tertiles of BMI and waist circumference were at the greatest risk (adjusted odds ratio (OR) = 4.6 (95% confidence interval (CI) = 1.9, 11.6), P(trend) = 0.002; OR = 5.1 (95% CI = 2.0, 13.0), P(trend) = 0.002, respectively) compared to females in the lowest tertiles. Adjustment for leptin and adiponectin attenuated these associations by 52 and 42%, respectively. Males in the highest tertile of waist-to-hip ratio were at the greatest risk (adjusted OR = 2.8 (95% CI = 1.3, 5.9), P(trend) = 0.014) compared to males in the lowest tertile. However, adjustment for leptin and adiponectin did not attenuate these associations. Our study results are consistent with the notion that circulating leptin and adiponectin partially mediate the obesity-BE relationship in women. Leptin and adiponectin's role in the progression from normal epithelium to SIM/BE and on to EA should be further elucidated.

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  • Authors+Show Affiliations

    ,

    Nutritional Sciences Program, The University of Washington, Seattle, Washington, USA. othompson@cfhnutrition.org

    , , ,

    Source

    Obesity (Silver Spring, Md.) 18:11 2010 Nov pg 2204-11

    MeSH

    Adiponectin
    Adult
    Aged
    Aged, 80 and over
    Barrett Esophagus
    Body Mass Index
    Case-Control Studies
    Esophagogastric Junction
    Female
    Humans
    Leptin
    Logistic Models
    Male
    Metaplasia
    Middle Aged
    Obesity
    Odds Ratio
    Risk Factors
    Sex Factors
    Waist-Hip Ratio
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    20111023

    Citation

    Thompson, Olivia M., et al. "Serum Leptin and Adiponectin Levels and Risk of Barrett's Esophagus and Intestinal Metaplasia of the Gastroesophageal Junction." Obesity (Silver Spring, Md.), vol. 18, no. 11, 2010, pp. 2204-11.
    Thompson OM, Beresford SA, Kirk EA, et al. Serum leptin and adiponectin levels and risk of Barrett's esophagus and intestinal metaplasia of the gastroesophageal junction. Obesity (Silver Spring). 2010;18(11):2204-11.
    Thompson, O. M., Beresford, S. A., Kirk, E. A., Bronner, M. P., & Vaughan, T. L. (2010). Serum leptin and adiponectin levels and risk of Barrett's esophagus and intestinal metaplasia of the gastroesophageal junction. Obesity (Silver Spring, Md.), 18(11), pp. 2204-11. doi:10.1038/oby.2009.508.
    Thompson OM, et al. Serum Leptin and Adiponectin Levels and Risk of Barrett's Esophagus and Intestinal Metaplasia of the Gastroesophageal Junction. Obesity (Silver Spring). 2010;18(11):2204-11. PubMed PMID: 20111023.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Serum leptin and adiponectin levels and risk of Barrett's esophagus and intestinal metaplasia of the gastroesophageal junction. AU - Thompson,Olivia M, AU - Beresford,Shirley A A, AU - Kirk,Elizabeth A, AU - Bronner,Mary P, AU - Vaughan,Thomas L, Y1 - 2010/01/28/ PY - 2010/1/30/entrez PY - 2010/1/30/pubmed PY - 2011/4/16/medline SP - 2204 EP - 11 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 18 IS - 11 N2 - Persons diagnosed with Barrett's esophagus (BE) are at increased risk of developing esophageal adenocarcinoma (EA). Obesity is a major risk factor for both BE and EA. The primary purposes of this study were to determine whether circulating levels of leptin and adiponectin, both of which are deregulated in obese states, predict risk of specialized intestinal metaplasia (SIM) occurring in the esophagus (BE) and/or gastroesophageal junction, and evaluate the extent to which they mediate the relationship between obesity and these conditions. In this case-control study, 177 persons newly diagnosed with SIM were compared with 173 general population controls using unconditional logistic regression. Females in the highest tertiles of BMI and waist circumference were at the greatest risk (adjusted odds ratio (OR) = 4.6 (95% confidence interval (CI) = 1.9, 11.6), P(trend) = 0.002; OR = 5.1 (95% CI = 2.0, 13.0), P(trend) = 0.002, respectively) compared to females in the lowest tertiles. Adjustment for leptin and adiponectin attenuated these associations by 52 and 42%, respectively. Males in the highest tertile of waist-to-hip ratio were at the greatest risk (adjusted OR = 2.8 (95% CI = 1.3, 5.9), P(trend) = 0.014) compared to males in the lowest tertile. However, adjustment for leptin and adiponectin did not attenuate these associations. Our study results are consistent with the notion that circulating leptin and adiponectin partially mediate the obesity-BE relationship in women. Leptin and adiponectin's role in the progression from normal epithelium to SIM/BE and on to EA should be further elucidated. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/20111023/Serum_leptin_and_adiponectin_levels_and_risk_of_Barrett's_esophagus_and_intestinal_metaplasia_of_the_gastroesophageal_junction_ L2 - https://doi.org/10.1038/oby.2009.508 DB - PRIME DP - Unbound Medicine ER -