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Air pollution exposure during pregnancy and reduced birth size: a prospective birth cohort study in Valencia, Spain.
Environ Health. 2010 Jan 29; 9:6.EH

Abstract

BACKGROUND

Maternal exposure to air pollution has been related to fetal growth in a number of recent scientific studies. The objective of this study was to assess the association between exposure to air pollution during pregnancy and anthropometric measures at birth in a cohort in Valencia, Spain.

METHODS

Seven hundred and eighty-five pregnant women and their singleton newborns participated in the study. Exposure to ambient nitrogen dioxide (NO2) was estimated by means of land use regression. NO2 spatial estimations were adjusted to correspond to relevant pregnancy periods (whole pregnancy and trimesters) for each woman. Outcome variables were birth weight, length, and head circumference (HC), along with being small for gestational age (SGA). The association between exposure to residential outdoor NO2 and outcomes was assessed controlling for potential confounders and examining the shape of the relationship using generalized additive models (GAM).

RESULTS

For continuous anthropometric measures, GAM indicated a change in slope at NO2 concentrations of around 40 microg/m3. NO2 exposure >40 microg/m3 during the first trimester was associated with a change in birth length of -0.27 cm (95% CI: -0.51 to -0.03) and with a change in birth weight of -40.3 grams (-96.3 to 15.6); the same exposure throughout the whole pregnancy was associated with a change in birth HC of -0.17 cm (-0.34 to -0.003). The shape of the relation was seen to be roughly linear for the risk of being SGA. A 10 microg/m3 increase in NO2 during the second trimester was associated with being SGA-weight, odds ratio (OR): 1.37 (1.01-1.85). For SGA-length the estimate for the same comparison was OR: 1.42 (0.89-2.25).

CONCLUSIONS

Prenatal exposure to traffic-related air pollution may reduce fetal growth. Findings from this study provide further evidence of the need for developing strategies to reduce air pollution in order to prevent risks to fetal health and development.

Authors+Show Affiliations

Center for Public Health Research (CSISP), Conselleria de Sanitat, 46020, Valencia, Spain. ballester_fer@gva.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20113501

Citation

Ballester, Ferran, et al. "Air Pollution Exposure During Pregnancy and Reduced Birth Size: a Prospective Birth Cohort Study in Valencia, Spain." Environmental Health : a Global Access Science Source, vol. 9, 2010, p. 6.
Ballester F, Estarlich M, Iñiguez C, et al. Air pollution exposure during pregnancy and reduced birth size: a prospective birth cohort study in Valencia, Spain. Environ Health. 2010;9:6.
Ballester, F., Estarlich, M., Iñiguez, C., Llop, S., Ramón, R., Esplugues, A., Lacasaña, M., & Rebagliato, M. (2010). Air pollution exposure during pregnancy and reduced birth size: a prospective birth cohort study in Valencia, Spain. Environmental Health : a Global Access Science Source, 9, 6. https://doi.org/10.1186/1476-069X-9-6
Ballester F, et al. Air Pollution Exposure During Pregnancy and Reduced Birth Size: a Prospective Birth Cohort Study in Valencia, Spain. Environ Health. 2010 Jan 29;9:6. PubMed PMID: 20113501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Air pollution exposure during pregnancy and reduced birth size: a prospective birth cohort study in Valencia, Spain. AU - Ballester,Ferran, AU - Estarlich,Marisa, AU - Iñiguez,Carmen, AU - Llop,Sabrina, AU - Ramón,Rosa, AU - Esplugues,Ana, AU - Lacasaña,Marina, AU - Rebagliato,Marisa, Y1 - 2010/01/29/ PY - 2009/10/23/received PY - 2010/01/29/accepted PY - 2010/2/2/entrez PY - 2010/2/2/pubmed PY - 2010/4/28/medline SP - 6 EP - 6 JF - Environmental health : a global access science source JO - Environ Health VL - 9 N2 - BACKGROUND: Maternal exposure to air pollution has been related to fetal growth in a number of recent scientific studies. The objective of this study was to assess the association between exposure to air pollution during pregnancy and anthropometric measures at birth in a cohort in Valencia, Spain. METHODS: Seven hundred and eighty-five pregnant women and their singleton newborns participated in the study. Exposure to ambient nitrogen dioxide (NO2) was estimated by means of land use regression. NO2 spatial estimations were adjusted to correspond to relevant pregnancy periods (whole pregnancy and trimesters) for each woman. Outcome variables were birth weight, length, and head circumference (HC), along with being small for gestational age (SGA). The association between exposure to residential outdoor NO2 and outcomes was assessed controlling for potential confounders and examining the shape of the relationship using generalized additive models (GAM). RESULTS: For continuous anthropometric measures, GAM indicated a change in slope at NO2 concentrations of around 40 microg/m3. NO2 exposure >40 microg/m3 during the first trimester was associated with a change in birth length of -0.27 cm (95% CI: -0.51 to -0.03) and with a change in birth weight of -40.3 grams (-96.3 to 15.6); the same exposure throughout the whole pregnancy was associated with a change in birth HC of -0.17 cm (-0.34 to -0.003). The shape of the relation was seen to be roughly linear for the risk of being SGA. A 10 microg/m3 increase in NO2 during the second trimester was associated with being SGA-weight, odds ratio (OR): 1.37 (1.01-1.85). For SGA-length the estimate for the same comparison was OR: 1.42 (0.89-2.25). CONCLUSIONS: Prenatal exposure to traffic-related air pollution may reduce fetal growth. Findings from this study provide further evidence of the need for developing strategies to reduce air pollution in order to prevent risks to fetal health and development. SN - 1476-069X UR - https://www.unboundmedicine.com/medline/citation/20113501/Air_pollution_exposure_during_pregnancy_and_reduced_birth_size:_a_prospective_birth_cohort_study_in_Valencia_Spain_ L2 - https://ehjournal.biomedcentral.com/articles/10.1186/1476-069X-9-6 DB - PRIME DP - Unbound Medicine ER -