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[Correlation between left ventricular diastolic function and plasma natriuretic peptide level in children with pulmonary artery hypertension secondary to congenital heart disease].
Zhongguo Dang Dai Er Ke Za Zhi. 2010 Jan; 12(1):13-6.ZD

Abstract

OBJECTIVE

To study the plasma natriuretic peptide (BNP) level in children with pulmonary artery hypertension (PAH) secondary to congenital heart disease (CHD) and its correlation with left ventricular diastolic function.

METHODS

Doppler echocardiography was performed on 95 CHD children with PAH (PAH group) and on 42 CHD without PAH (control group). The plasma BNP level was measured using radioimmunity assay.

RESULTS

Doppler echocardiography showed that the left ventricular end-diastolic diameter (LVDd), the right ventricular diameter end-diastolic (RVDd), and the pulmonary artery diameter (PAd) increased significantly in the PAH group compared with those in the control group (p<0.05). The PAH group had higher velocity of tricuspid regurgitation (VTR) and higher pulmonary artery systolic pressure (PASP) than the control group (p<0.05). The PAH group also had higher mitral A peak velocity (AV), higher mitral A peak velocity integral (AVI), higher E peak velocity intgral (EVI), and higher ratio of mitral AV to mitral E peak velocity (EV) and AVI/EVI ratio as well as prolonged left ventricular volumetric relaxation time than the control group. PASP was positively correlated with the AV/EV ratio (p<0.05). The plasma BNP level in the PAH group increased significantly compared with that in the control group. In the PAH group, the plasma BNP level was positively correlated with the pulmonary artery pressure and the ratio of AV/EV.

CONCLUSIONS

The left ventricular diastolic function is positively correlated with the plasma BNP level in children with PAH secondary to CHD. BNP may play an important role in the generation and development of left ventricular diastolic dysfunction induced by PAH.

Authors+Show Affiliations

Second Department of Cardiology, General Hospital of People's Liberation Army, Beijing 100853, China. bjcuihua@yahoo.com.cnNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

20113626

Citation

Cui, Hua, et al. "[Correlation Between Left Ventricular Diastolic Function and Plasma Natriuretic Peptide Level in Children With Pulmonary Artery Hypertension Secondary to Congenital Heart Disease]." Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, vol. 12, no. 1, 2010, pp. 13-6.
Cui H, Hu YX, Feng ZC. [Correlation between left ventricular diastolic function and plasma natriuretic peptide level in children with pulmonary artery hypertension secondary to congenital heart disease]. Zhongguo Dang Dai Er Ke Za Zhi. 2010;12(1):13-6.
Cui, H., Hu, Y. X., & Feng, Z. C. (2010). [Correlation between left ventricular diastolic function and plasma natriuretic peptide level in children with pulmonary artery hypertension secondary to congenital heart disease]. Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 12(1), 13-6.
Cui H, Hu YX, Feng ZC. [Correlation Between Left Ventricular Diastolic Function and Plasma Natriuretic Peptide Level in Children With Pulmonary Artery Hypertension Secondary to Congenital Heart Disease]. Zhongguo Dang Dai Er Ke Za Zhi. 2010;12(1):13-6. PubMed PMID: 20113626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Correlation between left ventricular diastolic function and plasma natriuretic peptide level in children with pulmonary artery hypertension secondary to congenital heart disease]. AU - Cui,Hua, AU - Hu,Yi-Xin, AU - Feng,Zhi-Chun, PY - 2010/2/2/entrez PY - 2010/2/2/pubmed PY - 2010/5/19/medline SP - 13 EP - 6 JF - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics JO - Zhongguo Dang Dai Er Ke Za Zhi VL - 12 IS - 1 N2 - OBJECTIVE: To study the plasma natriuretic peptide (BNP) level in children with pulmonary artery hypertension (PAH) secondary to congenital heart disease (CHD) and its correlation with left ventricular diastolic function. METHODS: Doppler echocardiography was performed on 95 CHD children with PAH (PAH group) and on 42 CHD without PAH (control group). The plasma BNP level was measured using radioimmunity assay. RESULTS: Doppler echocardiography showed that the left ventricular end-diastolic diameter (LVDd), the right ventricular diameter end-diastolic (RVDd), and the pulmonary artery diameter (PAd) increased significantly in the PAH group compared with those in the control group (p<0.05). The PAH group had higher velocity of tricuspid regurgitation (VTR) and higher pulmonary artery systolic pressure (PASP) than the control group (p<0.05). The PAH group also had higher mitral A peak velocity (AV), higher mitral A peak velocity integral (AVI), higher E peak velocity intgral (EVI), and higher ratio of mitral AV to mitral E peak velocity (EV) and AVI/EVI ratio as well as prolonged left ventricular volumetric relaxation time than the control group. PASP was positively correlated with the AV/EV ratio (p<0.05). The plasma BNP level in the PAH group increased significantly compared with that in the control group. In the PAH group, the plasma BNP level was positively correlated with the pulmonary artery pressure and the ratio of AV/EV. CONCLUSIONS: The left ventricular diastolic function is positively correlated with the plasma BNP level in children with PAH secondary to CHD. BNP may play an important role in the generation and development of left ventricular diastolic dysfunction induced by PAH. SN - 1008-8830 UR - https://www.unboundmedicine.com/medline/citation/20113626/[Correlation_between_left_ventricular_diastolic_function_and_plasma_natriuretic_peptide_level_in_children_with_pulmonary_artery_hypertension_secondary_to_congenital_heart_disease]_ L2 - http://www.zgddek.com/EN/abstract/abstract12151.shtml DB - PRIME DP - Unbound Medicine ER -