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Carriers of inactive hepatitis B virus are still at risk for hepatocellular carcinoma and liver-related death.
Gastroenterology 2010; 138(5):1747-54G

Abstract

BACKGROUND & AIMS

The risk and the predictors of liver disease progression in carriers of inactive hepatitis B virus (HBV) are unclear.

METHODS

Participants in the Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer-Hepatitis B Virus (REVEAL-HBV) study who were seronegative for hepatitis B e antigen; had serum levels of HBV DNA <10,000 copies/mL; and did not have cirrhosis, hepatocellular carcinoma, or increased serum levels of alanine aminotransferase were classified as carriers of inactive HBV (n = 1932). Study participants who were seronegative for HB surface antigen and antibodies against hepatitis C virus, yet had similar clinical liver features, were the controls (n = 18,137). Liver-related death and new cases of hepatocellular carcinoma were ascertained through computerized data linkage with National Cancer Registry and Death Certification profiles. The disease progression rates were estimated. The multivariate-adjusted hazard ratios for risk predictors were derived from Cox regression models.

RESULTS

There were 20,069 participants, contributing a total of 262,122 person-years, with a mean follow-up of 13.1 years. Annual incidence rates of hepatocellular carcinoma and liver-related death were 0.06% and 0.04%, respectively, for inactive HBV carriers; rates were 0.02%, and 0.02% for controls, respectively. The multivariate-adjusted hazard ratios for carriers of inactive HBV, compared to controls, were 4.6 (95% confidence interval: 2.5-8.3) for hepatocellular carcinoma and 2.1 (95% confidence interval: 1.1-4.1) for liver-related death. Older age and alcohol drinking habits were independent predictors of risk for carriers of inactive HBV to develop hepatocellular carcinoma.

CONCLUSIONS

Carriers of inactive HBV have a substantial risk of hepatocellular carcinoma and liver-related death compared with individuals not infected with HBV.

Authors+Show Affiliations

Department of Internal Medicine, Bei-Hu Branch, National Taiwan University Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20114048

Citation

Chen, Jin-De, et al. "Carriers of Inactive Hepatitis B Virus Are Still at Risk for Hepatocellular Carcinoma and Liver-related Death." Gastroenterology, vol. 138, no. 5, 2010, pp. 1747-54.
Chen JD, Yang HI, Iloeje UH, et al. Carriers of inactive hepatitis B virus are still at risk for hepatocellular carcinoma and liver-related death. Gastroenterology. 2010;138(5):1747-54.
Chen, J. D., Yang, H. I., Iloeje, U. H., You, S. L., Lu, S. N., Wang, L. Y., ... Chen, C. J. (2010). Carriers of inactive hepatitis B virus are still at risk for hepatocellular carcinoma and liver-related death. Gastroenterology, 138(5), pp. 1747-54. doi:10.1053/j.gastro.2010.01.042.
Chen JD, et al. Carriers of Inactive Hepatitis B Virus Are Still at Risk for Hepatocellular Carcinoma and Liver-related Death. Gastroenterology. 2010;138(5):1747-54. PubMed PMID: 20114048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carriers of inactive hepatitis B virus are still at risk for hepatocellular carcinoma and liver-related death. AU - Chen,Jin-De, AU - Yang,Hwai-I, AU - Iloeje,Uchenna H, AU - You,San-Lin, AU - Lu,Sheng-Nan, AU - Wang,Li-Yu, AU - Su,Jun, AU - Sun,Chien-An, AU - Liaw,Yun-Fan, AU - Chen,Chien-Jen, AU - ,, Y1 - 2010/01/28/ PY - 2009/10/28/received PY - 2009/12/17/revised PY - 2010/01/20/accepted PY - 2010/2/2/entrez PY - 2010/2/2/pubmed PY - 2010/5/8/medline SP - 1747 EP - 54 JF - Gastroenterology JO - Gastroenterology VL - 138 IS - 5 N2 - BACKGROUND & AIMS: The risk and the predictors of liver disease progression in carriers of inactive hepatitis B virus (HBV) are unclear. METHODS: Participants in the Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer-Hepatitis B Virus (REVEAL-HBV) study who were seronegative for hepatitis B e antigen; had serum levels of HBV DNA <10,000 copies/mL; and did not have cirrhosis, hepatocellular carcinoma, or increased serum levels of alanine aminotransferase were classified as carriers of inactive HBV (n = 1932). Study participants who were seronegative for HB surface antigen and antibodies against hepatitis C virus, yet had similar clinical liver features, were the controls (n = 18,137). Liver-related death and new cases of hepatocellular carcinoma were ascertained through computerized data linkage with National Cancer Registry and Death Certification profiles. The disease progression rates were estimated. The multivariate-adjusted hazard ratios for risk predictors were derived from Cox regression models. RESULTS: There were 20,069 participants, contributing a total of 262,122 person-years, with a mean follow-up of 13.1 years. Annual incidence rates of hepatocellular carcinoma and liver-related death were 0.06% and 0.04%, respectively, for inactive HBV carriers; rates were 0.02%, and 0.02% for controls, respectively. The multivariate-adjusted hazard ratios for carriers of inactive HBV, compared to controls, were 4.6 (95% confidence interval: 2.5-8.3) for hepatocellular carcinoma and 2.1 (95% confidence interval: 1.1-4.1) for liver-related death. Older age and alcohol drinking habits were independent predictors of risk for carriers of inactive HBV to develop hepatocellular carcinoma. CONCLUSIONS: Carriers of inactive HBV have a substantial risk of hepatocellular carcinoma and liver-related death compared with individuals not infected with HBV. SN - 1528-0012 UR - https://www.unboundmedicine.com/medline/citation/20114048/Carriers_of_inactive_hepatitis_B_virus_are_still_at_risk_for_hepatocellular_carcinoma_and_liver_related_death_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(10)00148-4 DB - PRIME DP - Unbound Medicine ER -