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A prospective study of vitamin intake and the risk of hearing loss in men.

Abstract

OBJECTIVE

Hearing loss is the most common sensory disorder in the United States, afflicting more than 36 million people. Higher intakes of vitamins C, E, beta carotene, B12, and folate have been proposed to reduce the risk of hearing loss.

STUDY DESIGN

We prospectively evaluated the association between intake from foods and supplements of vitamins C, E, beta carotene, B12, and folate, and the incidence of hearing loss.

SETTING

Health Professionals Follow-up Study.

SUBJECTS AND METHODS

A total of 26,273 men aged 40 to 74 years at baseline in 1986. Participants completed questionnaires about lifestyle and medical history every two years and diet every four years. Information on self-reported professionally diagnosed hearing loss and year of diagnosis was obtained from the 2004 questionnaire, and cases were defined as hearing loss diagnosed between 1986 and 2004. Cox proportional hazards multivariate regression was used to adjust for potential confounders.

RESULTS

There were 3559 cases of hearing loss identified. Overall, there was no significant association between vitamin intake and risk of hearing loss. Among men aged > or =60 years, total folate intake was associated with a reduced risk of hearing loss; the relative risk for men aged > or =60 years old in the highest quintile compared with the lowest quintile of folate intake was 0.79 (95% confidence interval 0.65-0.96).

CONCLUSIONS

Higher intake of vitamin C, E, beta carotene, or B12 does not reduce the risk of hearing loss in adult males. Men aged > or =60 years may benefit from higher folate intake to reduce the risk of developing hearing loss.

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  • Authors+Show Affiliations

    ,

    Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, 181 Longwood Ave, Boston, MA 02115, USA. Josef_Shargorodsky@meei.harvard.edu

    , ,

    Source

    MeSH

    Adult
    Aged
    Ascorbic Acid
    Boston
    Diet
    Dietary Supplements
    Folic Acid
    Hearing Loss
    Humans
    Incidence
    Life Style
    Male
    Middle Aged
    Multivariate Analysis
    Proportional Hazards Models
    Prospective Studies
    Risk Assessment
    Risk Factors
    Smoking
    Surveys and Questionnaires
    Vitamin B Complex
    Vitamin E
    Vitamins
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20115980

    Citation

    Shargorodsky, Josef, et al. "A Prospective Study of Vitamin Intake and the Risk of Hearing Loss in Men." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 142, no. 2, 2010, pp. 231-6.
    Shargorodsky J, Curhan SG, Eavey R, et al. A prospective study of vitamin intake and the risk of hearing loss in men. Otolaryngol Head Neck Surg. 2010;142(2):231-6.
    Shargorodsky, J., Curhan, S. G., Eavey, R., & Curhan, G. C. (2010). A prospective study of vitamin intake and the risk of hearing loss in men. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 142(2), pp. 231-6. doi:10.1016/j.otohns.2009.10.049.
    Shargorodsky J, et al. A Prospective Study of Vitamin Intake and the Risk of Hearing Loss in Men. Otolaryngol Head Neck Surg. 2010;142(2):231-6. PubMed PMID: 20115980.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A prospective study of vitamin intake and the risk of hearing loss in men. AU - Shargorodsky,Josef, AU - Curhan,Sharon G, AU - Eavey,Roland, AU - Curhan,Gary C, PY - 2009/09/10/received PY - 2009/10/21/revised PY - 2009/10/28/accepted PY - 2010/2/2/entrez PY - 2010/2/2/pubmed PY - 2010/3/13/medline SP - 231 EP - 6 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 142 IS - 2 N2 - OBJECTIVE: Hearing loss is the most common sensory disorder in the United States, afflicting more than 36 million people. Higher intakes of vitamins C, E, beta carotene, B12, and folate have been proposed to reduce the risk of hearing loss. STUDY DESIGN: We prospectively evaluated the association between intake from foods and supplements of vitamins C, E, beta carotene, B12, and folate, and the incidence of hearing loss. SETTING: Health Professionals Follow-up Study. SUBJECTS AND METHODS: A total of 26,273 men aged 40 to 74 years at baseline in 1986. Participants completed questionnaires about lifestyle and medical history every two years and diet every four years. Information on self-reported professionally diagnosed hearing loss and year of diagnosis was obtained from the 2004 questionnaire, and cases were defined as hearing loss diagnosed between 1986 and 2004. Cox proportional hazards multivariate regression was used to adjust for potential confounders. RESULTS: There were 3559 cases of hearing loss identified. Overall, there was no significant association between vitamin intake and risk of hearing loss. Among men aged > or =60 years, total folate intake was associated with a reduced risk of hearing loss; the relative risk for men aged > or =60 years old in the highest quintile compared with the lowest quintile of folate intake was 0.79 (95% confidence interval 0.65-0.96). CONCLUSIONS: Higher intake of vitamin C, E, beta carotene, or B12 does not reduce the risk of hearing loss in adult males. Men aged > or =60 years may benefit from higher folate intake to reduce the risk of developing hearing loss. SN - 1097-6817 UR - https://www.unboundmedicine.com/medline/citation/20115980/A_prospective_study_of_vitamin_intake_and_the_risk_of_hearing_loss_in_men_ L2 - http://journals.sagepub.com/doi/full/10.1016/j.otohns.2009.10.049?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -