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Dietary carotenoids and risk of hormone receptor-defined breast cancer in a prospective cohort of Swedish women.
Eur J Cancer 2010; 46(6):1079-85EJ

Abstract

Carotenoids have antioxidant and antiproliferative properties and may reduce the risk of breast cancer. We examined the association between dietary carotenoids and risk of invasive breast cancer in the Swedish Mammography Cohort, a population-based cohort of 36,664 women who completed a questionnaire in 1997. During a mean follow-up of 9.4 years, 1008 women were diagnosed with incident breast cancer. Dietary carotenoids were not significantly associated with the risk of breast cancer overall or with any subtype defined by oestrogen receptor (ER) and progesterone receptor (PR) status. However, dietary alpha-carotene and beta-carotene were inversely associated with the risk of ER-PR-breast cancer among ever smokers. Among ever smokers, the multivariable relative risks of ER-PR-breast cancer comparing the highest with the lowest quintile of intake were 0.32 (95% confidence interval (CI): 0.11-0.94; P(trend)=0.01) for alpha-carotene and 0.35 (95% CI: 0.12-0.99; P(trend)=0.03) for beta-carotene. The risk of breast cancer also decreased with increasing intakes of alpha-carotene (P(trend) = 0.02) and beta-carotene (P(trend)=0.01) among women who did not use dietary supplements. These findings suggest that dietary alpha-carotene and beta-carotene are inversely associated with the risk of breast cancer among smokers and among women who do not use dietary supplements.

Authors+Show Affiliations

Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. susanna.larsson@ki.se

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20116235

Citation

Larsson, Susanna C., et al. "Dietary Carotenoids and Risk of Hormone Receptor-defined Breast Cancer in a Prospective Cohort of Swedish Women." European Journal of Cancer (Oxford, England : 1990), vol. 46, no. 6, 2010, pp. 1079-85.
Larsson SC, Bergkvist L, Wolk A. Dietary carotenoids and risk of hormone receptor-defined breast cancer in a prospective cohort of Swedish women. Eur J Cancer. 2010;46(6):1079-85.
Larsson, S. C., Bergkvist, L., & Wolk, A. (2010). Dietary carotenoids and risk of hormone receptor-defined breast cancer in a prospective cohort of Swedish women. European Journal of Cancer (Oxford, England : 1990), 46(6), pp. 1079-85. doi:10.1016/j.ejca.2010.01.004.
Larsson SC, Bergkvist L, Wolk A. Dietary Carotenoids and Risk of Hormone Receptor-defined Breast Cancer in a Prospective Cohort of Swedish Women. Eur J Cancer. 2010;46(6):1079-85. PubMed PMID: 20116235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary carotenoids and risk of hormone receptor-defined breast cancer in a prospective cohort of Swedish women. AU - Larsson,Susanna C, AU - Bergkvist,Leif, AU - Wolk,Alicja, Y1 - 2010/01/28/ PY - 2009/11/04/received PY - 2009/12/25/revised PY - 2010/01/06/accepted PY - 2010/2/2/entrez PY - 2010/2/2/pubmed PY - 2010/6/15/medline SP - 1079 EP - 85 JF - European journal of cancer (Oxford, England : 1990) JO - Eur. J. Cancer VL - 46 IS - 6 N2 - Carotenoids have antioxidant and antiproliferative properties and may reduce the risk of breast cancer. We examined the association between dietary carotenoids and risk of invasive breast cancer in the Swedish Mammography Cohort, a population-based cohort of 36,664 women who completed a questionnaire in 1997. During a mean follow-up of 9.4 years, 1008 women were diagnosed with incident breast cancer. Dietary carotenoids were not significantly associated with the risk of breast cancer overall or with any subtype defined by oestrogen receptor (ER) and progesterone receptor (PR) status. However, dietary alpha-carotene and beta-carotene were inversely associated with the risk of ER-PR-breast cancer among ever smokers. Among ever smokers, the multivariable relative risks of ER-PR-breast cancer comparing the highest with the lowest quintile of intake were 0.32 (95% confidence interval (CI): 0.11-0.94; P(trend)=0.01) for alpha-carotene and 0.35 (95% CI: 0.12-0.99; P(trend)=0.03) for beta-carotene. The risk of breast cancer also decreased with increasing intakes of alpha-carotene (P(trend) = 0.02) and beta-carotene (P(trend)=0.01) among women who did not use dietary supplements. These findings suggest that dietary alpha-carotene and beta-carotene are inversely associated with the risk of breast cancer among smokers and among women who do not use dietary supplements. SN - 1879-0852 UR - https://www.unboundmedicine.com/medline/citation/20116235/Dietary_carotenoids_and_risk_of_hormone_receptor_defined_breast_cancer_in_a_prospective_cohort_of_Swedish_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959-8049(10)00005-5 DB - PRIME DP - Unbound Medicine ER -