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Optimal cutoff value of high-density lipoprotein cholesterol for predicting coronary artery disease in Taiwanese population.
Nutr Res. 2010 Jan; 30(1):21-6.NR

Abstract

The aim of this study was to determine if an optimal cutoff value for high-density lipoprotein cholesterol (HDL-C) can be obtained for predicting the risk of coronary artery disease (CAD) in Taiwanese population. We conducted a hospital-based case-control study. Patients identified by cardiac catheterization as having at least 70% stenosis of one major coronary artery and without diabetes were assigned to the case group (n = 184). The control group (n = 516) was composed of healthy individuals with normal blood biochemical values. The multiple logistic regression analysis was used to evaluate linear association between low-density lipoprotein cholesterol (LDL-C), HDL-C, or LDL-C/HDL-C ratio and CAD while adjusting for confounders. Furthermore, receiver operating characteristic curve analyses were constructed. Individuals with an HDL-C value less than or equal to 60 mg/dL had the significantly highest odds ratio (7.72; 95% confidence interval, 2.70-22.07) after adjusting for LDL-C, LDL-C/HDL-C ratio, and other potential confounders. The areas under the curves were 0.85 and 0.61 for HDL-C and LDL-C, respectively. The optimal cutoff value of HDL-C for predicting the presence of CAD was 46 mg/dL. Sensitivity and specificity using this cutoff value were 71.74% and 81.40%, respectively. Our findings suggest that subjects with lower levels of HDL-C have a much higher risk of CAD than those with higher levels of LDL-C. The optimal cutoff value for HDL-C in predicting the risk of CAD is considered as 46 mg/dL in the Taiwanese population.

Authors+Show Affiliations

School of Nutrition, Chung Shan Medical University, Taichung 402, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20116656

Citation

Huang, Yi-Chia, et al. "Optimal Cutoff Value of High-density Lipoprotein Cholesterol for Predicting Coronary Artery Disease in Taiwanese Population." Nutrition Research (New York, N.Y.), vol. 30, no. 1, 2010, pp. 21-6.
Huang YC, Ho CC, Lin PT, et al. Optimal cutoff value of high-density lipoprotein cholesterol for predicting coronary artery disease in Taiwanese population. Nutr Res. 2010;30(1):21-6.
Huang, Y. C., Ho, C. C., Lin, P. T., Lee, B. J., Lai, C. H., & Liaw, Y. P. (2010). Optimal cutoff value of high-density lipoprotein cholesterol for predicting coronary artery disease in Taiwanese population. Nutrition Research (New York, N.Y.), 30(1), 21-6. https://doi.org/10.1016/j.nutres.2009.11.003
Huang YC, et al. Optimal Cutoff Value of High-density Lipoprotein Cholesterol for Predicting Coronary Artery Disease in Taiwanese Population. Nutr Res. 2010;30(1):21-6. PubMed PMID: 20116656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimal cutoff value of high-density lipoprotein cholesterol for predicting coronary artery disease in Taiwanese population. AU - Huang,Yi-Chia, AU - Ho,Chien-Chang, AU - Lin,Ping-Ting, AU - Lee,Bor-Jen, AU - Lai,Cheng-Hsiu, AU - Liaw,Yung-Po, PY - 2009/09/16/received PY - 2009/11/12/revised PY - 2009/11/16/accepted PY - 2010/2/2/entrez PY - 2010/2/2/pubmed PY - 2010/4/20/medline SP - 21 EP - 6 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 30 IS - 1 N2 - The aim of this study was to determine if an optimal cutoff value for high-density lipoprotein cholesterol (HDL-C) can be obtained for predicting the risk of coronary artery disease (CAD) in Taiwanese population. We conducted a hospital-based case-control study. Patients identified by cardiac catheterization as having at least 70% stenosis of one major coronary artery and without diabetes were assigned to the case group (n = 184). The control group (n = 516) was composed of healthy individuals with normal blood biochemical values. The multiple logistic regression analysis was used to evaluate linear association between low-density lipoprotein cholesterol (LDL-C), HDL-C, or LDL-C/HDL-C ratio and CAD while adjusting for confounders. Furthermore, receiver operating characteristic curve analyses were constructed. Individuals with an HDL-C value less than or equal to 60 mg/dL had the significantly highest odds ratio (7.72; 95% confidence interval, 2.70-22.07) after adjusting for LDL-C, LDL-C/HDL-C ratio, and other potential confounders. The areas under the curves were 0.85 and 0.61 for HDL-C and LDL-C, respectively. The optimal cutoff value of HDL-C for predicting the presence of CAD was 46 mg/dL. Sensitivity and specificity using this cutoff value were 71.74% and 81.40%, respectively. Our findings suggest that subjects with lower levels of HDL-C have a much higher risk of CAD than those with higher levels of LDL-C. The optimal cutoff value for HDL-C in predicting the risk of CAD is considered as 46 mg/dL in the Taiwanese population. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/20116656/Optimal_cutoff_value_of_high_density_lipoprotein_cholesterol_for_predicting_coronary_artery_disease_in_Taiwanese_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(09)00244-9 DB - PRIME DP - Unbound Medicine ER -