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Efficacy of plasma beta-hydroxybutyrate concentration as a marker for diabetes mellitus in acutely sick cats.
J Feline Med Surg 2010; 12(4):300-5JF

Abstract

Urine ketone measurement is routinely performed in cats with diabetes mellitus to identify impending or established ketoacidosis. Studies using the urinary ketone dipstick test have shown that ketonuria is common in cats with newly diagnosed untreated diabetes mellitus. This test has a low sensitivity as it quantifies the less abundant ketone acetoacetate. The objective of the present study was to determine if ketonaemia is an inherent biochemical finding in untreated feline diabetes mellitus by measuring plasma ss-hydroxybutyrate (ss-OHB) in acutely sick cats. In 122 sick cats (37 diabetic and 85 non-diabetic cats) plasma ss-OHB, glucose, fructosamine, total protein and thyroxine were measured as part of the routine work up. Diabetic cats had significantly elevated ss-OHB values and ss-OHB measurement was a sensitive and specific test to identify diabetes mellitus. The area under the receiver operating characteristic (ROC) curve was 0.93. The cut off value with the highest positive likelihood ratio was 0.58 mmol/l. These results suggest that determination of plasma ss-OHB concentration is a useful method to distinguish between diabetic and non-diabetic sick cats.

Authors+Show Affiliations

Clinic for Small Animals and Infectious Diseases, Department for Companion Animals and Horses, University of Veterinary Medicine Vienna, Veterinaerplatz, 1210 Vienna, Austria. f.zeugswetter@vetmeduni.ac.atNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20117951

Citation

Zeugswetter, Florian, et al. "Efficacy of Plasma Beta-hydroxybutyrate Concentration as a Marker for Diabetes Mellitus in Acutely Sick Cats." Journal of Feline Medicine and Surgery, vol. 12, no. 4, 2010, pp. 300-5.
Zeugswetter F, Handl S, Iben C, et al. Efficacy of plasma beta-hydroxybutyrate concentration as a marker for diabetes mellitus in acutely sick cats. J Feline Med Surg. 2010;12(4):300-5.
Zeugswetter, F., Handl, S., Iben, C., & Schwendenwein, I. (2010). Efficacy of plasma beta-hydroxybutyrate concentration as a marker for diabetes mellitus in acutely sick cats. Journal of Feline Medicine and Surgery, 12(4), pp. 300-5. doi:10.1016/j.jfms.2009.10.002.
Zeugswetter F, et al. Efficacy of Plasma Beta-hydroxybutyrate Concentration as a Marker for Diabetes Mellitus in Acutely Sick Cats. J Feline Med Surg. 2010;12(4):300-5. PubMed PMID: 20117951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of plasma beta-hydroxybutyrate concentration as a marker for diabetes mellitus in acutely sick cats. AU - Zeugswetter,Florian, AU - Handl,Stephanie, AU - Iben,Christine, AU - Schwendenwein,Ilse, Y1 - 2010/02/01/ PY - 2009/10/08/accepted PY - 2010/2/2/entrez PY - 2010/2/2/pubmed PY - 2010/6/24/medline SP - 300 EP - 5 JF - Journal of feline medicine and surgery JO - J. Feline Med. Surg. VL - 12 IS - 4 N2 - Urine ketone measurement is routinely performed in cats with diabetes mellitus to identify impending or established ketoacidosis. Studies using the urinary ketone dipstick test have shown that ketonuria is common in cats with newly diagnosed untreated diabetes mellitus. This test has a low sensitivity as it quantifies the less abundant ketone acetoacetate. The objective of the present study was to determine if ketonaemia is an inherent biochemical finding in untreated feline diabetes mellitus by measuring plasma ss-hydroxybutyrate (ss-OHB) in acutely sick cats. In 122 sick cats (37 diabetic and 85 non-diabetic cats) plasma ss-OHB, glucose, fructosamine, total protein and thyroxine were measured as part of the routine work up. Diabetic cats had significantly elevated ss-OHB values and ss-OHB measurement was a sensitive and specific test to identify diabetes mellitus. The area under the receiver operating characteristic (ROC) curve was 0.93. The cut off value with the highest positive likelihood ratio was 0.58 mmol/l. These results suggest that determination of plasma ss-OHB concentration is a useful method to distinguish between diabetic and non-diabetic sick cats. SN - 1532-2750 UR - https://www.unboundmedicine.com/medline/citation/20117951/Efficacy_of_plasma_beta_hydroxybutyrate_concentration_as_a_marker_for_diabetes_mellitus_in_acutely_sick_cats_ L2 - http://journals.sagepub.com/doi/full/10.1016/j.jfms.2009.10.002?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -