Tags

Type your tag names separated by a space and hit enter

Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal development.
Nat Cell Biol. 2010 Mar; 12(3):257-66.NC

Abstract

Satellite cells are resident myogenic progenitors in postnatal skeletal muscle involved in muscle postnatal growth and adult regenerative capacity. Here, we identify and describe a population of muscle-resident stem cells, which are located in the interstitium, that express the cell stress mediator PW1 but do not express other markers of muscle stem cells such as Pax7. PW1(+)/Pax7(-) interstitial cells (PICs) are myogenic in vitro and efficiently contribute to skeletal muscle regeneration in vivo as well as generating satellite cells and PICs. Whereas Pax7 mutant satellite cells show robust myogenic potential, Pax7 mutant PICs are unable to participate in myogenesis and accumulate during postnatal growth. Furthermore, we found that PICs are not derived from a satellite cell lineage. Taken together, our findings uncover a new and anatomically identifiable population of muscle progenitors and define a key role for Pax7 in a non-satellite cell population during postnatal muscle growth.

Authors+Show Affiliations

Myology Group, UMR S 787 INSERM, Université Pierre et Marie Curie Paris VI, Paris, 75634, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20118923

Citation

Mitchell, Kathryn J., et al. "Identification and Characterization of a Non-satellite Cell Muscle Resident Progenitor During Postnatal Development." Nature Cell Biology, vol. 12, no. 3, 2010, pp. 257-66.
Mitchell KJ, Pannérec A, Cadot B, et al. Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal development. Nat Cell Biol. 2010;12(3):257-66.
Mitchell, K. J., Pannérec, A., Cadot, B., Parlakian, A., Besson, V., Gomes, E. R., Marazzi, G., & Sassoon, D. A. (2010). Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal development. Nature Cell Biology, 12(3), 257-66. https://doi.org/10.1038/ncb2025
Mitchell KJ, et al. Identification and Characterization of a Non-satellite Cell Muscle Resident Progenitor During Postnatal Development. Nat Cell Biol. 2010;12(3):257-66. PubMed PMID: 20118923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal development. AU - Mitchell,Kathryn J, AU - Pannérec,Alice, AU - Cadot,Bruno, AU - Parlakian,Ara, AU - Besson,Vanessa, AU - Gomes,Edgar R, AU - Marazzi,Giovanna, AU - Sassoon,David A, Y1 - 2010/01/31/ PY - 2009/11/17/received PY - 2010/01/14/accepted PY - 2010/2/2/entrez PY - 2010/2/2/pubmed PY - 2010/4/13/medline SP - 257 EP - 66 JF - Nature cell biology JO - Nat. Cell Biol. VL - 12 IS - 3 N2 - Satellite cells are resident myogenic progenitors in postnatal skeletal muscle involved in muscle postnatal growth and adult regenerative capacity. Here, we identify and describe a population of muscle-resident stem cells, which are located in the interstitium, that express the cell stress mediator PW1 but do not express other markers of muscle stem cells such as Pax7. PW1(+)/Pax7(-) interstitial cells (PICs) are myogenic in vitro and efficiently contribute to skeletal muscle regeneration in vivo as well as generating satellite cells and PICs. Whereas Pax7 mutant satellite cells show robust myogenic potential, Pax7 mutant PICs are unable to participate in myogenesis and accumulate during postnatal growth. Furthermore, we found that PICs are not derived from a satellite cell lineage. Taken together, our findings uncover a new and anatomically identifiable population of muscle progenitors and define a key role for Pax7 in a non-satellite cell population during postnatal muscle growth. SN - 1476-4679 UR - https://www.unboundmedicine.com/medline/citation/20118923/Identification_and_characterization_of_a_non_satellite_cell_muscle_resident_progenitor_during_postnatal_development_ L2 - http://dx.doi.org/10.1038/ncb2025 DB - PRIME DP - Unbound Medicine ER -