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Ispagula powder: an allergen in the work environment.

Abstract

Bulk laxatives based on ispagula powder have given no known allergic side effects when administered perorally. Twenty-seven out of 64 workers in a pharmaceutical factory developed rhinitis, conjunctivitis or asthma when engaged in the packing of ispagula husks, an operation which gives rise to dust. The symptoms are accounted for by a type 1 allergy acquired from ispagula husks. This allergy can be demonstrated by intracutaneous and provocation tests. Occupational health measures were taken which reduced the dust content to a minimum; thereafter only one new case of sensitization was recorded during the next 24 months of observation. Five similar cases were reported among nursing staff exposed to the dust of ispagula while administering doses of bulk laxative.

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  • Authors+Show Affiliations

    ,

    Department of Dermatology, University Hospital, Umeå, Sweden.

    Source

    MeSH

    Adult
    Air Pollutants, Occupational
    Allergens
    Asthma
    Case-Control Studies
    Conjunctivitis, Allergic
    Drug Industry
    Dust
    Female
    Humans
    Inhalation Exposure
    Laxatives
    Male
    Occupational Diseases
    Occupational Exposure
    Psyllium
    Skin Tests

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    20120573

    Citation

    TY - JOUR T1 - Ispagula powder: an allergen in the work environment. AU - Göransson,K, AU - Michaelson,N G, PY - 2010/2/4/entrez PY - 1979/9/1/pubmed PY - 2010/4/14/medline SP - 257 EP - 61 JF - Scandinavian journal of work, environment & health JO - Scand J Work Environ Health VL - 5 IS - 3 N2 - Bulk laxatives based on ispagula powder have given no known allergic side effects when administered perorally. Twenty-seven out of 64 workers in a pharmaceutical factory developed rhinitis, conjunctivitis or asthma when engaged in the packing of ispagula husks, an operation which gives rise to dust. The symptoms are accounted for by a type 1 allergy acquired from ispagula husks. This allergy can be demonstrated by intracutaneous and provocation tests. Occupational health measures were taken which reduced the dust content to a minimum; thereafter only one new case of sensitization was recorded during the next 24 months of observation. Five similar cases were reported among nursing staff exposed to the dust of ispagula while administering doses of bulk laxative. SN - 0355-3140 UR - https://www.unboundmedicine.com/medline/citation/20120573/Ispagula_powder:_an_allergen_in_the_work_environment_ L2 - http://www.sjweh.fi/show_abstract.php?abstract_id=3099 ER -