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Association of single nucleotide polymorphisms in adiponectin and its receptor genes with polycystic ovary syndrome.
J Reprod Med. 2009 Nov-Dec; 54(11-12):669-74.JR

Abstract

OBJECTIVE

To examine the possible association of adiponectin (ADIPOQ), adiponectin receptor (ADIPOR1/2) gene polymorphisms with polycystic ovary syndrome (PCOS) and their influence on insulin resistance in Japanese women with PCOS.

STUDY DESIGN

Six single nucleotide polymorphisms (SNPs) in ADIPOQ and ADIPOR1/2 were genotyped in 59 infertile Japanese women with PCOS and 97 healthy Japanese controls. In addition, the association between the genotype and allele frequencies of these SNPs and the clinical phenotypes was analyzed in PCOS patients.

RESULTS

There was no significant difference in the genotype and allele frequencies of the 6 SNPs between PCOS patients and controls. In the PCOS group, women with the GG genotype of 45T > G of ADIPOQ had a significantly higher score in the homeostasis model assessment for insulin resistance, fasting blood sugar and insulin level than those with other genotypes. Furthermore, a statistically significant difference in the genotype frequency of 45T > G polymorphism was observed between PCOS subjects with insulin resistance (n = 38) and controls (p = 0.011).

CONCLUSION

The 6 SNPs of ADIPOQ and ADIPOR1/2 were not associated with a risk of PCOS. However, the 45T > G SNP in the ADIPOQ may be related to insulin resistance in Japanese women with PCOS.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata University, Chuo Ward, Niigata, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20120899

Citation

Yoshihara, Kosuke, et al. "Association of Single Nucleotide Polymorphisms in Adiponectin and Its Receptor Genes With Polycystic Ovary Syndrome." The Journal of Reproductive Medicine, vol. 54, no. 11-12, 2009, pp. 669-74.
Yoshihara K, Yahata T, Kashima K, et al. Association of single nucleotide polymorphisms in adiponectin and its receptor genes with polycystic ovary syndrome. J Reprod Med. 2009;54(11-12):669-74.
Yoshihara, K., Yahata, T., Kashima, K., Mikami, T., & Tanaka, K. (2009). Association of single nucleotide polymorphisms in adiponectin and its receptor genes with polycystic ovary syndrome. The Journal of Reproductive Medicine, 54(11-12), 669-74.
Yoshihara K, et al. Association of Single Nucleotide Polymorphisms in Adiponectin and Its Receptor Genes With Polycystic Ovary Syndrome. J Reprod Med. 2009 Nov-Dec;54(11-12):669-74. PubMed PMID: 20120899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of single nucleotide polymorphisms in adiponectin and its receptor genes with polycystic ovary syndrome. AU - Yoshihara,Kosuke, AU - Yahata,Tetsuro, AU - Kashima,Katsunori, AU - Mikami,Takeaki, AU - Tanaka,Kenichi, PY - 2010/2/4/entrez PY - 2010/2/4/pubmed PY - 2010/3/10/medline SP - 669 EP - 74 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 54 IS - 11-12 N2 - OBJECTIVE: To examine the possible association of adiponectin (ADIPOQ), adiponectin receptor (ADIPOR1/2) gene polymorphisms with polycystic ovary syndrome (PCOS) and their influence on insulin resistance in Japanese women with PCOS. STUDY DESIGN: Six single nucleotide polymorphisms (SNPs) in ADIPOQ and ADIPOR1/2 were genotyped in 59 infertile Japanese women with PCOS and 97 healthy Japanese controls. In addition, the association between the genotype and allele frequencies of these SNPs and the clinical phenotypes was analyzed in PCOS patients. RESULTS: There was no significant difference in the genotype and allele frequencies of the 6 SNPs between PCOS patients and controls. In the PCOS group, women with the GG genotype of 45T > G of ADIPOQ had a significantly higher score in the homeostasis model assessment for insulin resistance, fasting blood sugar and insulin level than those with other genotypes. Furthermore, a statistically significant difference in the genotype frequency of 45T > G polymorphism was observed between PCOS subjects with insulin resistance (n = 38) and controls (p = 0.011). CONCLUSION: The 6 SNPs of ADIPOQ and ADIPOR1/2 were not associated with a risk of PCOS. However, the 45T > G SNP in the ADIPOQ may be related to insulin resistance in Japanese women with PCOS. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/20120899/Association_of_single_nucleotide_polymorphisms_in_adiponectin_and_its_receptor_genes_with_polycystic_ovary_syndrome_ L2 - https://medlineplus.gov/polycysticovarysyndrome.html DB - PRIME DP - Unbound Medicine ER -